Version 2.77

Term Description

Detection of pathologic prions in cerebrospinal fluid (CSF). The test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%.
Source: Regenstrief LOINC

Part Descriptions

LP35078-2   Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

LP435248-2   RT-QuIC
Real-time quaking-induced conversion (RT-QuIC) a technique to detect small amounts of PrPSc.. RT-QuIC test manipulates the ability of PrPSc to induce PrPC to misfold in a cyclical fashion to form aggregates of PrPSc fibrils, in real time by binding to a fluorescent dye, namely thioflavin T. Source: LOINC

Fully-Specified Name

Component
Prion protein.abnormal
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
RT-QuIC

Additional Names

Short Name
Abn Prion Prot CSF Ql RT-QuIC
Display Name
Abnormal Prion Protein RT-QuIC Ql (CSF)
Consumer Name Alpha Get Info
Abnormal prion protein, Spinal fluid

Example Answer List: LL2038-9

Source: Quest Diagnostics Inc.
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
104134-2 Dementia evaluation panel - Cerebral spinal fluid

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) Proteina prionica.anormale:PrThr:Pt:LCS:Ord:RT-QuIC
Synonyms: Chimica Liquido cerebrospinale Presenza o Soglia Proteina Prionica Anormale Punto nel tempo (episodio) Real Time Quaking Induced Conversion
nl-NL Dutch (Netherlands) prioneiwit.abnormaal:aanwezigheid:moment:liquor cerebrospinalis:ordinaal:RT-QulC
Synonyms: real-time quaking-induced conversion
zh-CN Chinese (China) 朊病毒蛋白.异常:存在情况或阈值:时间点:脑脊液:序数型:RT-QuIC
Synonyms: BSE;Scrapie;亲染子蛋白.异常;异常亲染子蛋白;异常感染性蛋白质;异常朊病毒蛋白;异常蛋白感染素;感染性蛋白质.异常;牛海绵状脑病;牛海绵状脑病（Bovine spongiform encephalopathy，BSE）;疯牛病;羊痒病;羊瘙痒病;羊瘙痒病（Scrapie）;蛋白感染素.异常 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 不平常的 不正常的 亲染子蛋白 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 反常的 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 实时震荡诱导转化 异常的 感染性蛋白质 时刻;随机;随意;瞬间 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 蛋白感染素 非一般的 非惯例的

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101662-5