Version 2.77

Term Description

Identifying monoclonal gammopathy isotypes using random urine specimens.
Source: Regenstrief LOINC

Part Descriptions

LP186074-3   MS.MALDI-TOF
Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) is a type of mass spectrometry (MS). MALDI-TOF MS consists of three primary steps: 1) mixing the sample with an organic matrix, which provides a scaffolding and also protons for the ionization process; 2) applying a laser to the matrix, which absorbs energy from the laser and releases it into the sample, which causes the sample to desorb and form singly charged ions; and 3) using a flight tube to analyze the mass of the ions, ultimately resulting in a mass spectrum in which the mass-to-charge is plotted against signal intensity. MALDI-TOF is a soft ionization technique, meaning that molecules remain relatively intact during ionization. Because of this property, MALDI-TOF can be used for protein analysis; in contrast, older MS techniques cause extensive protein fragmentation and therefore cannot be used for this purpose. One application of MALDI-TOF is in clinical microbiology; compared to traditional methods, MALDI-TOF is faster and more accurate in identifying specific microorganisms. PMID: 23824373 Source: Regenstrief LOINC, PMID: 23824373

LP269335-8   Protein.monoclonal isotype
A monoclonal band (M-spike, monoclonal protein isotype) is often found in patients with monoclonal gammopathies. Following protein electrophoresis, immunofixation is used to identify the immunoglobulin heavy chain and/or light chain. Monoclonal peaks greater than 3 g/dL and IgG or IgA are seen in patients with Multiple Myeloma (MM). A monoclonal peak greater than 3 g/dL and IgM is seen in patients with macroglobulinemia. An alternate methodology for identifying the monoclonal protein isotype is MALDI-TOF, in which known information regarding the unique mass of each isotype is used to determine and quantify the isotype present in the patient sample based on the mass spectra generated from the sample. Source: Regenstrief LOINC

Fully-Specified Name

Component
Protein.monoclonal isotype
Property
Prid
Time
Pt
System
Urine
Scale
Nom
Method
MS.MALDI-TOF

Additional Names

Short Name
M Protein isotype Ur MS.MALDI-TOF
Display Name
Protein.monoclonal isotype MS.MALDI-TOF Nom (U)
Consumer Name Alpha Get Info
Protein.monoclonal isotype, Urine

Example Answer List: LL5149-1

Source: NCBI PubMed
Answer Code Score Answer ID
No monoclonal protein detected LA29537-0
Monoclonal IgA lambda LA29536-2
Monoclonal IgG kappa LA29538-8
Monoclonal IgM kappa LA29539-6

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
101668-2 Protein electrophoresis and M protein isotype panel - Urine

Member of these Groups Get Info

LOINC Group Group Name
LG51451-9 Protein.monoclonal isotype|Prid|Urine

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Isotipo de proteína monoclonal:Presencia o identidad:Punto temporal:Orina:Nom:MS.MALDI-TOF
it-IT Italian (Italy) Proteina.isotipo monoclonale:Prid:Pt:Urine:Nom:MS.MALDI-TOF
Synonyms: Chimica Presenza o Identità Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) eiwit.monoklonaal isotype:identificator:moment:urine:nominaal:MALDI-TOF
Synonyms: massaspectometrie; Malditof
pl-PL Polish (Poland) Izotyp białka monoklonalnego:wykrycie lub identyfikacja:punkt w czasie:mocz:cecha:spektrometria mas.MALDI-TOF
zh-CN Chinese (China) 蛋白质.单克隆同种型:存在与否或特征标识:时间点:尿液:名义型:MS.MALDI-TOF
Synonyms: M 区带;M 峰;M 带;M 蛋白;副蛋白;单克隆区带;单克隆型蛋白质;单克隆型蛋白质区带;单克隆峰;单克隆性蛋白质;单克隆性蛋白质区带;单克隆蛋白质区带;异常蛋白;病变蛋白;蛋白质.单克隆 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 基质辅助激光解吸/电离飞行时间质谱;基质辅助激光解吸电离飞行时间质谱;基质辅助激光解吸飞行时间质谱;基质辅助激光解析电离飞行时间质谱;Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry;MALDI-TOF-MS;Matrix-assisted laser desorption ionization-time of flight 存在;存在与否;特征标识;身份;身份标识 尿;小便;下泉 时刻;随机;随意;瞬间 蛋白质（蛋白）.单克隆同种型;单克隆同种型蛋白质（蛋白）

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