Version 2.77

Part Descriptions

LP250847-3   Certolizumab
Certolizumab is a monoclonal antibody conjugated to polyethylene glycol used to treat Crohn's Disease (CD) and rheumatoid arthritis (RA). Certolizumab pegol binds to tumor necrosis factor alpha (TNFα), a pro-inflammatory cytokine that is implicated in the pathogenesis of a number of immunological diseases including CD and RA. TNFα mediates the signature inflammation-induced joint damage in RA. The reduction of TNFα alleviates symptoms of RA, CD and other immunologic diseases. TNFα-inhibitors have been hugely successful in treating immunological diseases. In spite of the positive impact TNFα-inhibitors have had there is still variability in response to their use including loss of response over time and drug tolerance. PMID: 20190560 Source: Regenstrief LOINC

LP250850-7   Certolizumab Ab
Antibodies to certolizumab were detected in about 22% of patients during a 7-year clinical trial of patients with Crohn's disease. Approximately 22% of antibody-positive patients had transient antibodies, and the rest had persistent anti-certolizumab antibodies. Those with persistent antibodies had lower plasma certolizumab concentration and drug efficacy compared to those with transient antibodies as well as those patients who were antibody-negative. PMID: 28410341 Source: Regenstrief LOINC

LP435249-0   SPR
Surface plasmon resonance is an optical technique used to measure the binding between two proteins, a protein and an antibody or DNA and a protein. Source: LOINC

Fully-Specified Name

Component
Certolizumab Ab
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
SPR

Additional Names

Short Name
Certolizumab Ab SerPl SPR-mCnc
Display Name
Certolizumab Ab SPR [Mass/Vol]
Consumer Name Alpha Get Info
Certolizumab antibody, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) Certolizumab pegol Ab:MCnc:Pt:Siero/Plasma:Qn:SPR
Synonyms: anticorpo Certolizumab pegolo Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Risonanza Plasmonica di Superficie Siero Siero o Plasma
nl-NL Dutch (Netherlands) certolizumab As:massa/volume:moment:serum of plasma:kwantitatief:SPR
Synonyms: antistof; antilichaam surface plasmon resonantie; SPR
zh-CN Chinese (China) 塞妥珠单抗 抗体:质量浓度:时间点:血清/血浆:定量型:SPR
Synonyms: Ab;自身抗体 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 塞妥珠单克隆抗体;塞妥珠;Certolizumab 单抗 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆 表面等离子共振

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101724-3