106057-3
Beta-Amyloid 1-42 and 1-40 panel - Cerebral spinal fluid
Active
98485-6 Amyloid beta 42 peptide/Amyloid beta 40 peptide [Mass Ratio] in Cerebral spinal fluid
Part Descriptions
LP30823-6 Amyloid beta 42 peptide
Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's.
Source: Regenstrief Institute
LP30823-6 Amyloid beta 42 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.
The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.
Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- Amyloid beta 42 peptide/Amyloid beta 40 peptide
- Property
- MRto
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Additional Names
- Panel Name
- Short Name
- AL beta42/ABeta 40 CSF
- Display Name
- Amyloid beta 42 peptide/Amyloid beta 40 peptide (CSF) [Mass ratio]
- Consumer Name Alpha Get Info
- Amyloid beta 42 peptide/Amyloid beta 40 peptide, Spinal fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.71
- Last Updated
- Version 2.74
- Change Reason
- Release 2.74: ORDER_OBS: Classified as both an order and an observation;
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
| 106057-3 | Beta-Amyloid 1-42 and 1-40 panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: Amyloid Beta 42/Amyloid Beta 40 Ratio /L |
| es-ES | Spanish (Spain) | Péptido beta amiloide 42/Péptido amiloide beta 40 (Aβ40): Synonyms: Cuantitativo |
| fr-FR | French (France) | Peptide bêta amyloïde 1-42/peptide bêta amyloïde 1-40: |
| it-IT | Italian (Italy) | Amiloide beta 42 peptide/Amiloide beta 40 peptide: Synonyms: Chimica Liquido cerebrospinale Punto nel tempo (episodio) Rapporto di Massa |
| nl-NL | Dutch (Netherlands) | amyloïd-bèta-42-peptide/amyloïd-bèta-40-peptide: Synonyms: amyloid beta 40 peptide amyloid beta 42 peptide |
| zh-CN | Chinese (China) | 淀粉样蛋白 Beta 42 肽/淀粉样蛋白 Beta 40 肽: Synonyms: Ab40 肽; |
Example Units
| Unit | Source |
|---|---|
| pg/pg | Example UCUM Units |
33203-1 Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid
Part Descriptions
LP30823-6 Amyloid beta 42 peptide
Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's.
Source: Regenstrief Institute
LP30823-6 Amyloid beta 42 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.
The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.
Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- Amyloid beta 42 peptide
- Property
- MCnc
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Additional Names
- Panel Name
- Short Name
- AL beta42 CSF-mCnc
- Display Name
- Amyloid beta 42 peptide (CSF) [Mass/Vol]
- Consumer Name Alpha Get Info
- Amyloid beta 42 peptide, Spinal fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.09
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 17504
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
| 106057-3 | Beta-Amyloid 1-42 and 1-40 panel - Cerebral spinal fluid |
| 104134-2 | Dementia evaluation panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: Amyloid Beta 42 /L |
| de-DE | German (Germany) | Amyloid-beta-42-Peptid: Synonyms: Zerebrospinalflüssigkeit |
| es-AR | Spanish (Argentina) | péptido amiloide beta 42: |
| es-ES | Spanish (Spain) | Péptido beta amiloide 42: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Péptido beta 42 amiloide: |
| fr-BE | French (Belgium) | Peptide amyloïde béta 42: |
| fr-CA | French (Canada) | Peptide amyloïde bêta 42: |
| fr-FR | French (France) | Peptide bêta amyloïde 1-42: |
| it-IT | Italian (Italy) | Amiloide beta 42 peptide: Synonyms: Chimica Concentrazione di Massa Liquido cerebrospinale Punto nel tempo (episodio) |
| ko-KR | Korean (Korea, Republic Of) | 아밀로이드 베타 42 펩티드: |
| nl-NL | Dutch (Netherlands) | amyloïd-bèta-42-peptide: Synonyms: amyloid beta 42 peptide |
| pt-BR | Portuguese (Brazil) | Beta amilóide 42 peptídeo: Synonyms: ; |
| ru-RU | Russian (Russian Federation) | Амилоид бета 42 пептид: Synonyms: Количественный Массовая концентрация Точка во времени; |
| tr-TR | Turkish (Turkey) | Amiloid beta 42 peptid: |
| zh-CN | Chinese (China) | 淀粉样蛋白 Beta 42 肽: Synonyms: Ab42 peptide; |
Example Units
| Unit | Source |
|---|---|
| pg/mL | Example UCUM Units |
70072-4 Amyloid beta 40 peptide [Mass/volume] in Cerebral spinal fluid
Part Descriptions
LP145733-4 Amyloid beta 40 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.
The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.
Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- Amyloid beta 40 peptide
- Property
- MCnc
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
Additional Names
- Panel Name
- Short Name
- AL beta40 CSF-mCnc
- Display Name
- Amyloid beta 40 peptide (CSF) [Mass/Vol]
- Consumer Name Alpha Get Info
- Amyloid beta 40 peptide, Spinal fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.40
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 18066
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 98492-2 | Apolipoprotein E and beta amyloid Alzheimer's risk panel - Cerebral spinal fluid |
| 106057-3 | Beta-Amyloid 1-42 and 1-40 panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: Amyloid Beta 40 Peptid /L |
| es-MX | Spanish (Mexico) | Péptido beta 40 amiloide: |
| es-ES | Spanish (Spain) | Péptido amiloide beta 40: Synonyms: Cuantitativo |
| fr-FR | French (France) | Peptide bêta amyloïde 1-40: |
| it-IT | Italian (Italy) | Amiloide beta 40 peptide: Synonyms: Chimica Concentrazione di Massa Liquido cerebrospinale Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | amyloïd-bèta-40-peptide: Synonyms: amyloid beta 40 peptide |
| pt-BR | Portuguese (Brazil) | Beta amilóide 40 peptídeo: |
| ru-RU | Russian (Russian Federation) | Амилоид бета 40 пептид: Synonyms: Количественный Массовая концентрация Точка во времени; |
| tr-TR | Turkish (Turkey) | Amiloid beta 40 peptid: |
| zh-CN | Chinese (China) | 淀粉样蛋白 Beta 40 肽: Synonyms: B CSF CSF; |
Example Units
| Unit | Source |
|---|---|
| pg/mL | Example UCUM Units |