Version 2.78

Part Description

LP19847-0   t(8;21)(q22;q22.3)(RUNX1T1,RUNX1)
Translocation (8;21) resulting in a fused transcript between RUNX1T1 (also known as ETO) and RUNX1 genes is one of the most common chromosomal translocations found in acute myeloid leukemia (AML). The RUNX1T1-RUNX1 fusion transcript is found in approximately 12% of all AML patients. RUNX1 is a transcription factor that regulates critical processes in many aspects of hematopoiesis and is essential in defining the final hematopoietic stem cell. It is involved in many forms of chromosomal translocations in leukemia. In addition, many hematological diseases have been associated with mutations in RUNX1. PMID: 22201794 Source: Regenstrief LOINC, PMID: 22201794

Fully-Specified Name

Component
t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript
Property
Arb
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
Molgen

Additional Names

Short Name
t(8;21)(RUNX1T1,RUNX1) Bld/T Ql
Display Name
t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript Molgen Ql (Bld/Tiss)
Consumer Name Alpha Get Info
t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusion transcript analysis, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.TRNLOC
Type
Laboratory
First Released
Version 1.0m
Last Updated
Version 2.73
Change Reason
Changed gene names CBFA2T1 to RUNX1T1 and CBFA2 to RUNX1, the recommended gene names by the HUGO Gene Nomenclature Committee (HGNC). Updated Component part to harmonize with ISCN guidelines and current LOINC nomenclature.
Order vs. Observation
Both
Common Test Rank Get Info
5876

Member of these Panels

LOINC Long Common Name
72103-5 Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Translokation (8,21)
es-AR Spanish (Argentina) translocación del gen T(8,21)(CBFA2T1,CBFA2):arbitrario:punto en el tiempo:sangre entera/tejido:ordinal:genética molecular
es-ES Spanish (Spain) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) Tránscritos de fusión:Arbitrario:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MX Spanish (Mexico) t (8; 21) (q22; q22.3) (RUNX1T1, RUNX1) transcripción de fusión:Arbitrario:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-FR French (France) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) transcrit de fusion:Arbitraire:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
fr-CA French (Canada) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) transcrit de fusion:Arbitraire:Temps ponctuel:Sang/Tissu:Ordinal:Molgen
it-IT Italian (Italy) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1), trascritto di fusione:Arb:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Arbitrario Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
ko-KR Korean (Korea, Republic Of) t(8,21)(CBFA2T1,CBFA2) 유전자 전위:임의적분:검사시점:전혈/조직:순위척도:분자유전
nl-NL Dutch (Netherlands) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) fusietranscript:aanwezigheid:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek
Synonyms: molgen
pt-BR Portuguese (Brazil) t(8,21)(CBFA2T1,CBFA2) translocação do gene:Arb:Pt:Sg/Tecido:Ord:Genética molecular
Synonyms: Arbitrary; Point in time; Random; Bld/T; Tissue; Bld/T; Blood; WB; Whole blood; Ql; Ordinal; QL; Qualitative; Qual; Screen; PCR; Molecular genetics; ALL; t(8,21)(q22,q22); T prime; ETO; AML1T1L myeloid translocation gene on 8q22; MTG8; Core binding factor runt domain alpha subunit 2; CDR; MGC2796; RUNX1T1; ZMYND2; Acute myelogenous leukemia 1 translocation 1, cyclin-D related; AML1; Acute myeloid leukemia 1; MOLPATH.TRANSLOCATION; MOLPATH.TRANSLOCATION; Molecular pathology
ru-RU Russian (Russian Federation) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) слияния транскрипт:Произв:ТчкВрм:Кр/Тк:Пор:МолГен
Synonyms: Кровь Кровь или Ткань Порядковый Произвольный Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR Turkish (Turkey) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) füzyon transkript:Sç:Zmlı:Kan/Dk:Srl:Molgen
zh-CN Chinese (China) t(8;21)(q22;q22.3)(RUNX1T1,RUNX1) 融合转录物:任意型:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: AML1 CDR ETO MGC2796 MTG8 RUNX1T1 T(8,21)(CBFA2T1,CBFA2) 基因易位;T(8,21)(CBFA2T1,CBFA2) 易位 ZMYND2 任意;任意的;人工型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 急性髓性白血病 1 急性髓性白血病 1 易位 1, 细胞周期蛋白-D 相关性 急性髓性白血病 1 染色体易位 1, 细胞周期蛋白-D 相关性 急性髓系白细胞 1 急性髓系白细胞 1 易位 1, 细胞周期蛋白-D 相关性 急性髓系白细胞 1 易位 1, 细胞周期蛋白-D 相关性（Acute myelogenous leukemia 1 translocation 1, cyclin-D related） 急性髓系白细胞 1 染色体易位 1, 细胞周期蛋白-D 相关性 急性髓系白细胞 1（Acute myeloid leukemia 1） 急性髓细胞白血病 1 急性髓细胞白血病 1 易位 1, 细胞周期蛋白-D 相关性 急性髓细胞白血病 1 染色体易位 1, 细胞周期蛋白-D 相关性 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染色体 8q22 之上的 AML1T1L 髓系易位基因 核心结合因子侏儒结构域 alpha 亚基 2 核心结合因子侏儒结构域α亚基 2 核心结合因子矮小域 alpha 亚基 2 核心结合因子矮小域α亚基 2 核心结合因子矮小结构域 alpha 亚基 2 核心结合因子矮小结构域 alpha 亚基 2（Core binding factor runt domain alpha subunit 2） 核心结合因子矮小结构域α亚基 2 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=21819-8