35333-4

Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

Active

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component

Jo-1 extractable nuclear Ab

Property

ACnc

Time

Pt

System

Ser

Scale

Qn

Method

IA

Additional Names

Long Common Name

Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

Short Name

ENA Jo1 Ab Ser IA-aCnc

Display Name

Jo-1 extractable nuclear Ab IA Qn (S)

Consumer Name Alpha Get Info

Jo-1 extractable nuclear antibody, Blood

Basic Attributes

Class

SERO

Type

Laboratory

First Released

Version 2.13

Last Updated

Version 2.73

Change Reason

The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

1856

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ABS
• Aby
• ANA
• ANF
• Antby
• Anti
• Antibodies
• Antibody
• Antinuclear antibody
• Arbitrary concentration
• Autoantibodies
• Autoantibody
• EIA
• ELFA
• ELISA
• ENA
• ENA Jo1
• Enzyme immunoassay
• Histidyl-tRNA synthease
• i
• IAA
• MEIA
• NA
• Nuc
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Serology
• Serum
• SR
• SUDS

Example Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.

CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=35333-4

LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.