Version 2.78

Part Descriptions

LP18633-5   Coproporphyrin 1
Coproporhyrin I is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin I is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Corproporphyrin I

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component
Coproporphyrin 1/Creatinine
Property
SRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Short Name
Copro1/Creat Ur-sRto
Display Name
Coproporphyrin 1/Creatinine (U) [Molar ratio]
Consumer Name Alpha Get Info
Coproporphyrin 1/Creatinine, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.17
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
5913

Member of these Panels

LOINC Long Common Name
93707-8 Porphyrin fractions panel - Urine

Member of these Groups Get Info

LOINC Group Group Name
LG36429-5 Coproporphyrin 1/Creatinine|SRto|Urine

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Koproporphyrin I/Kreatinin-Ratio /U
es-MX Spanish (Mexico) Coproporfirina 1 / Creatinina:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
es-ES Spanish (Spain) Coproporfirina 1/Creatinina:Relacion de Sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
fr-CA French (Canada) Coproporphyrine 1/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
fr-FR French (France) Coproporphyrine 1/créatinine:Moles ratio:Ponctuel:Urine:Numérique:
fr-BE French (Belgium) Coproporphyrine 1/Créatinine:Ratio de substance:Temps ponctuel:Urine:Quantitatif:
it-IT Italian (Italy) Coproporfirina 1/Creatinina:Srto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
nl-NL Dutch (Netherlands) coproporfyrine 1/creatinine:molaire verhouding:moment:urine:kwantitatief:
Synonyms: kreatinine
pt-BR Portuguese (Brazil) Coproporfirina 1/Creatinina:SCrto:Pt:Urina:Qn:
Synonyms: ; Copro1; Coproporphyrin I; Creat; CR; Coproporphyrins; Copro; Tetracarboxyporphyrin; Coproporph; Tetracarboxyl porphyrin; Tetracarboxylporphyrin; Tetracarboxylporphyrins; sRto; Substance concentration ratio; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Chemistry; UCr
ru-RU Russian (Russian Federation) Копропорфирин 1/Креатинин:МольОтн:ТчкВрм:Моча:Колич:
Synonyms: Количественный Мольная доля;Молярная доля;Отношение концентраций Точка во времени;Момент
tr-TR Turkish (Turkey) Koproporfirin 1/Kreatinin:SOrn:Zmlı:İdrar:Kant:
Synonyms: SubsOranı
zh-CN Chinese (China) 粪卟啉 I/肌酐:物质的量比率:时间点:尿液:定量型:
Synonyms: Ⅰ Copro;Coproporph;四羧基卟啉 Copro1;粪卟啉 1;粪卟啉Ⅰ CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 I UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 尿液肌酐 尿液肌酸酐 尿肌酸酐 时刻;随机;随意;瞬间 物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值 肌酸内酰胺

Example Units

Unit Source
mcmol/mol cr REGENSTRIEF
umol/mol eCHN
umol/mol{creat} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=45313-4