Version 2.78

Part Description

LP40499-3   Alpha-1-Microglobulin
Alpha-1-microglobulin (also called protein HC or A1M) is a 31-kD, single-chain plasma glycoprotein that may be involved in regulation of the inflammatory process. The alpha-1-microglobulin/bikunin precursor gene (AMBP) codes for a precursor that splits into alpha-1-microglobulin, which belongs to the lipocalin superfamily, and bikunin. A1M is normally present as a free form and as a complex with IgA in the blood, spinal fluid, and urine. A1M inhibits neutrophil chemotaxis to endotoxin-activated serum. [OMIM: 176870] Abnormal plasma/serum levels can be seen in liver or kidney disorders, and also in clinical conditions such as HIV and mood disorders. Urinary A1M is used for the early detection and monitoring of kidney tubular disorders such as heavy metal intoxications, diabetic nephropathy, urinary outflow disorders or pyelonephritis). PMID: 15256311 Increased urinary excretion of α1-microglobulin in tubular proteinuria indicates reduced tubular reabsorption under normal glomerular filtration conditions. This form of proteinuria is typical for chronic interstitial nephropathy and for acute and chronic tubular damage caused by endogenous and exogenous tubular toxins. In renal failure, plasma levels of this microprotein increase from an early stage. The resultant protein hyperfiltration in the residual nephron causes increased renal excretion as re-absorption capacity is exceeded. α1-Microglobulin can be used as a marker to diagnose tubulo-interstitial nephropathy, for example, at an early stage, or rule it out with a high degree of certainty. Acute and chronic forms of tubular insufficiency (all forms of primary and secondary Fanconi syndrome), heavy metal intoxication, nephrotoxic side-effects of pharmaceuticals, and rejection reactions following kidney transplantation can also be excluded. Source: Regenstrief LOINC, PMID: 15256311

Fully-Specified Name

Component
Alpha-1-Microglobulin
Property
MCnc
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Short Name
A1 Microglob Ur-mCnc
Display Name
Alpha-1-Microglobulin (U) [Mass/Vol]
Consumer Name Alpha Get Info
Alpha-1-Microglobulin, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.19
Last Updated
Version 2.34
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG51320-6 Alpha-1-Microglobulin|MCnc|Urine
LG47626-3 Alpha-1-Microglobulin|Pt|Urine

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: A1-Mikroglobulin /U
de-DE German (Germany) Alpha-1-Mikroglobulin:Massenkonzentration:Zeitpunkt:Urin:Quantitativ:
Synonyms: a1-Mikroglobulin
es-ES Spanish (Spain) Alfa 1-microglobulina:Concentración de masa:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Alfa-1-microglobulina:Concentración de masa:Punto temporal:Orina:Cuantitativo:
et-EE Estonian (Estonia) Alfa-1-mikroglobuliin:MCnc:Pt:U:Qn:
Synonyms: Juhuslik Kvantitatiivne Uriin
fr-CA French (Canada) Alpha-1-microglobuline:Concentration de masse:Temps ponctuel:Urine:Quantitatif:
fr-FR French (France) Alpha-1-microglobuline:Masse/Volume:Ponctuel:Urine:Numérique:
fr-BE French (Belgium) Alpha-1-microglobuline:Concentration de masse:Temps ponctuel:Urine:Quantitatif:
it-IT Italian (Italy) Alfa-1-Microglobulina:MCnc:Pt:Urine:Qn:
Synonyms: Chimica Concentrazione di Massa Punto nel tempo (episodio)
ko-KR Korean (Korea, Republic Of) 알파-1-마이크로글로불린:질량농도:검사시점:뇨:정량:
nl-NL Dutch (Netherlands) alfa-1-microglobuline:massa/volume:moment:urine:kwantitatief:
pt-BR Portuguese (Brazil) Alfa-1-Microglobulina:MCnc:Pt:Urina:Qn:
Synonyms: ; A1 Microglob; HC; Alpha-1-Microglycoprotein; Protein Human Complex; Mass concentration; Level; Point in time; Random; Ur; UR; Urn; UA; Quantitative; QNT; Quant; Quan; Alfa; I; Chemistry
ru-RU Russian (Russian Federation) Альфа-1-Микроглобулин:МассКонц:ТчкВрм:Моча:Колич:
Synonyms: Количественный Массовая концентрация Точка во времени;Момент
tr-TR Turkish (Turkey) Alfa-1-Mikroglobulin:KütlKons:Zmlı:İdrar:Kant:
zh-CN Chinese (China) Alpha-1-微球蛋白:质量浓度:时间点:尿液:定量型:
Synonyms: Ⅰ A1 型 A1MG;A-1-MG;A1-MG;Alpha-1-MG;Alpha-1-小球蛋白;Alpha1-小球蛋白;Alpha-1-微小球蛋白;Alpha1-微小球蛋白;Alpha-1-微小糖蛋白;Alpha1-微小糖蛋白;Alpha1-微球蛋白;HC;α1-MG;α1-小球蛋白;α1-微小球蛋白;α1-微小糖蛋白;α1-微球蛋白;人复合蛋白;人复合蛋白（Protein Human Complex，human complexforming protein，HC） I α α1 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 阿尔法

Example Units

Unit Source
mg/L Example UCUM Units
mg/L eCHN

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=46723-3