5218-3

Histoplasma capsulatum Ab [Presence] in Serum by Immune diffusion (ID)

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Part Description

LP16650-1   Histoplasma capsulatum
Histoplasmosis capsulatum is a dimorphic fungal pathogen with filamentous or yeast forms,depending on nutritional factors and temperature.The M antigen is a well-known glycoprotein used as a diagnostic antigen for acute histoplasmosis as it induces the first precipitins during disease. Monoclonal antibodies (mAbs) to the M antigen have been found to modify the pathogenesis of histoplasmosis.Given the shortcomings of current therapies, the administration of mAbs is being investigated. PMID: 22347215 The H band is less commonly seen than the M band and is indicative of chronic or severe acute infections with H capsulatum.

H. capsulatum is found in nature primarily as a saprophytic mold. The mold form is comprised of hyaline septate hyphae, which produce two different asexual reproduction structures, macroconidia and microconidia. The micronidia are believed to be responsible for disease propagation since their 2-6 µm size is well suited for disposition into the distal alveoli. Infection is typically acquired through inhalation of fungal propagules upon disturbances of contaminated soil or excreta. Environmental and genetic factors influence disease manifestations which can range from asymptomatic or mild influenza-like disease to a disseminated sepsis form. Manifestations depend on the magnitude of exposure, the host's immunological status and the virulence of the infective strain. Reactivation of latent infection can result in significant disease, particularly for immunosuppressed individuals. Despite the availability of potent antifungal drugs, nearly one in ten patients hospitalized with histoplasmosis dies. PMID: 17223625 Source: Regenstrief LOINC

Fully-Specified Name

Component

Histoplasma capsulatum Ab

Property

PrThr

Time

Pt

System

Ser

Scale

Ord

Method

Immune diffusion

Additional Names

Short Name

H capsul Ab Ser Ql ID

Display Name

H. capsulatum Ab Immune diff Ql (S)

Consumer Name Alpha Get Info

Histoplasma capsulatum antibody, Blood

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

3531

Member of these Panels

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Autoantibodies
• Autoantibody
• H capsul
• H capsulatum
• H farciminosum
• Histo
• Histopl
• Histoplasma farciminosum
• Histoplasmos
• Histoplasmosis
• ID
• Imm
• Immunodiff
• Immunodiffusion
• Imun
• Imune
• Infectious Disease
• InfectiousDisease
• Microbiology
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Screen
• Serum
• SR
• UniversalLabOrders

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=5218-3

LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.