Version 2.78

Term Description

Anti-Neuronal Nuclear Antibody Type 1 Cerebrospinal fluid (CSF) titer. This antibody recognizes a 35-40 kD component found in neuronal cell nuclei. ANNA-1 antibody is found almost exclusively in patients with a history of tobacco use or passive exposure. Women are affected twice as often as men. Cancer has been found in more than 90% of seropositive patients. Small cell lung carcinoma (SCLC) has been found in 80% of patients. A second malignant neoplasm is found in 13% of patients positive for ANNA-1 who have SCLC. The most common clinical presentation of patients positive for ANNA-1 is peripheral neuropathy, but they can exhibit any element of encephalomyeloradiculopathy. About 10% of patients present with gastroparesis or intestinal obstruction. ANNA-1 has also been detected in children with intestinal dysmotility, cerbellar ataxia, and brainstem encephalitis with and without neuroblastoma. It is detected in 5 to 10% of patients with SCLC who do not have a paraneoplastic syndrome. Paraneoplastic syndromes are autoantibody-mediated neurologic disorders associated with underlying tumors. These syndromes arise when systemic tumors express antigens normally found only in neural tissue. Serum is the preferred specimen. CSF results are sometimes positive when serum results are negative. If a lumbar puncture is going to be performed as part of the diagnostic workup, CSF testing is recommended to improve the detection rate. Information from http://www.clinlabnavigator.com accessed 2008 15 02.
Source: Regenstrief LOINC

Part Description

LP14163-7   Neuronal nuclear type 1
Type I anti-neuronal nuclear antibody (ANNA-1) is present in patients with paraneoplastic syndromes (paraneoplastic sensory neuropathy or paraneoplastic encephalomyelitis) most commonly associated with small-cell lung carcinoma (SCLC). ANNA-2 is present in patients with midbrain encephalitis, cerebellar ataxia, eye movement disorders (usually opsoclonus), and occasionally myelopathy. Neoplasms most often associated with ANNA-2 are breast carcinoma and SCLC. ANNA-1 and ANNA-2 may be detectable before the associated neoplasm is detectable. Source: ARUP Laboratories, ANNA

Fully-Specified Name

Component
Neuronal nuclear type 1 Ab
Property
Titr
Time
Pt
System
CSF
Scale
SemiQn
Method

Additional Names

Short Name
Hu1 Ab Titr CSF
Display Name
Neuronal nuclear type 1 Ab (CSF) [Titer]
Consumer Name Alpha Get Info
Neuronal nuclear type 1 antibody, Spinal fluid

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.75
Order vs. Observation
Both
Common Test Rank Get Info
14753

Member of these Groups Get Info

LOINC Group Group Name
LG8743-9 Neuronal nuclear type 1 Ab|Titr|Pt|CSF

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Anticuerpos Antineuronal nuclear tipo 1 Anticuerpos:Titulo / Factor de dilución:Punto temporal:Líquido Cefalorraquideo:Semicuantitativo:
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Ab de tipo 1 nuclear neuronal:Título:Punto temporal:Fluído espinal cerebral:Cuantitativo:
fr-CA French (Canada) Neuronal nucléaire de type 1, Ac:Titre:Temps ponctuel:LCR:SemiQn:
fr-FR French (France) Hu1 anticorps:Titre:Ponctuel:Liquide céphalorachidien:Semi-Quantitatif:
it-IT Italian (Italy) Nucleare neuronale tipo 1 Ab:Titr:Pt:LCS:SemiQn:
Synonyms: anticorpo Liquido cerebrospinale Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant Titolo
nl-NL Dutch (Netherlands) neuronaal nucleair type 1 As:titer:moment:liquor cerebrospinalis:semikwantitatief:
Synonyms: antistof; antilichaam soort
pl-PL Polish (Poland) Typ 1 neuronalny jądrowy Ab:miano:punkt w czasie:płyn mózgowo-rdzeniowy:półilościowy:
Synonyms: Przeciwciała do antygenów jądrowych neuronów typu 1 Przeciwciała onkoneuronalne
pt-BR Portuguese (Brazil) Neuronal nuclear tipo 1 Ac:Título:Pt:LCR:Qn:
Synonyms: Nuc; Hu1; ANNA 1; Hu; Neuronal nuclear type I; Dilution factor; Titer; Titre; Ttr; Titered; Point in time; Random; Cerebral spinal fluid; Spinal Fluid; Cerebrospinal Fl; Spinal Flu; Spinal Fld; Quantitative; QNT; Quant; Quan; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
zh-CN Chinese (China) 神经元细胞核 1 型 抗体:滴定度:时间点:脑脊液:半定量型:
Synonyms: Ⅰ Ab;自身抗体 ANNA 1 Ab ANNA 1 抗体 ANNA 1;ANNA-1;Hu;Hu1;神经元核 1 型;神经元细胞核 1 型（Neuronal nuclear type 1，ANNA 1） ANNA-1 Ab ANNA-1 抗体 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 Hu Ab Hu 抗体 Hu1 Ab Hu1 抗体 I 型 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间 核;胞核 神经元性;神经元的 神经元核 神经元核 1 型 Ab 神经元核 1 型抗体 神经元细胞核 1 型 Ab 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
titer REGENSTRIEF
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=53711-8