Version 2.78

Term Description

A patient's allelic genotype (e.g. *1/*12) at the CYP2C19 gene locus to determine CYP2C19 enzyme activity. Genotype results may be used to determine a patient's drug dose adjustment.
Source: Regenstrief LOINC

Part Description

LP417567-7   CYP2C19 gene allele
Cytochrome P450-2C19 (CYP2C19; [HGNC Gene ID: 2621]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism 10-15% of drugs in current clinical use. Genetic variations in CYP2C19 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP2C19 and selection of alternative dosing or agents may be necessary in individuals with specific CYP2C19 genetic variations. PMID: 23486447 PMID: 23698643 PMID: 25974703 See https://www.pharmgkb.org/gene/PA124 for more information and dosing guidelines for drugs impacted by CYP2C19 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Fully-Specified Name

Component
CYP2C19 gene allele
Property
Geno
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Long Common Name
CYP2C19 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
Short Name
CYP2C19 allele Geno Bld/T
Display Name
CYP2C19 gene allele genotype Molgen (Bld/Tiss)
Consumer Name Alpha Get Info
CYP2C19 gene allele genotype, Blood or tissue specimen

Example Answer List: LL950-7

Source: Regenstrief Institute
Answer Code Score Answer ID
CYP2C19*1/*1 LA13515-4
CYP2C19*1/*2 LA13516-2
CYP2C19*1/*3 LA13517-0
CYP2C19*2/*2 LA13518-8
CYP2C19*2/*3 LA13519-6
CYP2C19*3/*3 LA13520-4

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.73
Change Reason
Release 2.68: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; COMPONENT: Updated Component to align with the LOINC term naming model for concepts used to report allelic genotypes (e.g. CYP2C19*1/*12 ), which was the original intent for this term.; Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; Previous Releases: Added specimen of saliva since Cytochrome P450 gene testing is commonly done on saliva as well as blood specimens and results are theoretically the same for both.; Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
Order vs. Observation
Both
Common Test Rank Get Info
7198

Member of these Panels

LOINC Long Common Name
72886-5 CYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: CYP2C19 Genotyp.
es-ES Spanish (Spain) Alelo del gen CYP2C19:Genotipo:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX Spanish (Mexico) Alelo del gen CYP2C19:Genotipo:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR French (France) CYP2C19 gène allèle:Génotype:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) CYP2C19, gene allele:Geno:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Farmacogenomica Gene CYP2C19 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) CYP2C19-allel:genotype:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: CYP2C19 gen molgen
pt-BR Portuguese (Brazil) CYP2C19 análise de mutação do gene:Ident:Pt:Sg/Tecido:Nom:Genética molecular
Synonyms: cytochrome P-450 II C; cytochrome P450, family 2, subfamily C, polypeptide 19; Identity or presence; Point in time; Random; Bld/T; Tissue; Bld/T; Blood; WB; Whole blood; Nominal; PCR; Molecular genetics; Mut Anal; Mutations; MOLPATH.MUTATIONS; MOLPATH.MUTATIONS; Molecular pathology
zh-CN Chinese (China) CYP2C19 基因等位基因:基因型:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: Cytochrome P450, family 2, subfamily C, polypeptide 19;细胞色素 P450, 家族 2, 亚家族 C, 多肽 19;CYP2C19;细胞色素P450 2C19;Cytochrome P450 2C19 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

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