Version 2.78

Part Description

LP207652-1   HIV 1 RNA tropism
HIV enters cells by attaching first to the CD4 receptor and then to either the CCR5 or CXCR4 molecules, followed by fusion of the viral and cellular membranes. CCR5 coreceptor antagonists prevent HIV entry into target cells by binding to the CCR5 receptors. HIV tropism assays determine whether the HIV binds to CCR5, CXCR4 or both. An HIV tropism assay should be performed whenever the use of a CCR5 antagonist is being considered or a patient has virologic failure on a CCR5 antagonist.
During acute or recent infection, the vast majority of patients harbor a CCR5-binding virus (called R5 tropism), which suggests that the R5 variant is preferentially transmitted. Viruses in many untreated patients exhibit a shift in co-receptor tropism from CCR5 usage to either CXCR4 (X4 tropism) or both (D/M-tropic, which stands for dual or mixed), which is associated with a more rapid decline in CD4 T-cell counts. Patients who have been treated with anti-retroviral drugs and who have extensive drug resistance are more likely to harbor X4- or D/M-tropic variants than untreated patients with comparable CD4 counts. The prevalence of X4- or D/M-tropic variants increases to more than 50% in treated patients who have CD4 counts <100 cells/mm3. [https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf] Source: Regenstrief LOINC, NIH adult and adolescent HIV guidelines

Fully-Specified Name

Component
HIV 1 RNA tropism
Property
Prid
Time
Pt
System
Plas
Scale
Nar
Method

Additional Names

Short Name
HIV1 RNA tropism Plas
Display Name
HIV 1 RNA tropism Nar (P)
Consumer Name Alpha Get Info
HIV 1 RNA Tropism, Blood

Example Answer List: LL2265-8

Source: Regenstrief LOINC
Answer Code Score Answer ID
R5

Viruses or virus populations that use only the CCR5 chemokine co-receptor to infect CD4+ cells.

 LA19204-9
X4

Viruses or virus populations that use only the CXCR4 chemokine co-receptor to infect CD4+ cells.

 LA19205-6
D/M

Dual (D)-tropic: Viruses or virus populations that can use either the CCR5 or CXCR4 co-receptors to infect CD4+ cells. Mixed (M)-tropic: Virus populations that may contain various combinations of R5 virus, X4 virus, and/or dual-tropic viruses

 LA19206-4

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.29
Last Updated
Version 2.73
Change Reason
Changed class from MICRO to ABXBACT because the test result is used to inform anti-retroviral drug choice, added "RNA" to Component to clarify that the tropism is based on viral RNA and not proviral DNA.
Order vs. Observation
Both
Common Test Rank Get Info
10402

Member of these Panels

LOINC Long Common Name
75622-1 HIV 1 and 2 tests - Meaningful Use set

Language Variants Get Info

Tag Language Translation
es-MX Spanish (Mexico) Tropismo del ARN del VIH 1:Presencia o identidad:Punto temporal:Plasma:Narrativo:
es-ES Spanish (Spain) Tropismo del VIH 1 en ARN:Presencia o identidad:Punto temporal:Plasma:Narrativo:
fr-CA French (Canada) VIH 1 ARN tropisme:Présence ou identité:Temps ponctuel:Plasma:Narratif:
fr-FR French (France) VIH-1 ARN tropisme:Identification:Ponctuel:Plasma:Résultat textuel:
it-IT Italian (Italy) HIV 1 proviral RNA tropismo:Prid:Pt:Plasma:Nar:
Synonyms: Plasma Presenza o Identità Punto nel tempo (episodio) RNA dell''HIV 1 Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) HIV 1 RNA tropisme:identificator:moment:plasma:tekstueel:
pt-BR Portuguese (Brazil) HIV 1 tropismo:Ident:Pt:Plasma:Nar:
Synonyms: ; HIV1 tropism; CCR5; Trofile; Tropotype; CXCR4; R5; X4; CXCR4 (X4); HTLV III; HTLV 3; HIV type 1; HIV type I; AIDS; Human immunodeficiency virus; Identity or presence; Point in time; Random; Plasma; Pl; Plsm; Narrative; Report; Microbiology
uk-UA Ukrainian (Ukraine) ВІЛ 1 РНК тропізм:Наявність або Ідентифікація:МоментЧасу:Плазма:Описово:
Synonyms: AIDS; ANTIBIOTIC SUSCEPTIBILITIES; HIV type 1; HIV type I; HIV1; HIV1 RNA tropism; Human immunodeficiency virus; i; ID; Identity or presence; Infectious Disease; InfectiousDisease; Narrative; Pl; Plasma; Plsm; Point in time; Random; Report; Ribonucleic acid
zh-CN Chinese (China) HIV 1 型 RNA 嗜性:存在与否或特征标识:时间点:血浆:叙述型:
Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） RNA 嗜性（向性、趋性、趋向性） HIV1 RNA HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 存在;存在与否;特征标识;身份;身份标识 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间 核糖核酸;Ribonucleic acid

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=57182-8