6014-5
von Willebrand factor (vWf) ristocetin cofactor actual/normal in Platelet poor plasma by Platelet aggregation
Active
Part Description
LP174102-6 von Willebrand factor.ristocetin cofactor activity actual/Normal
Von Willebrand disease (VWD) is caused by either a qualitative or quantitative deficit of the multimeric glycoprotein known as von Willebrand factor (VWF). VWD affects 1-2% of the world population, making it the most common inherited bleeding disorder. VWF plays a crucial role in primary hemostasis by triggering platelet adhesion to injured vessel walls and promoting platelet aggregation. VWF also protects factor VIII from premature degradation in the peripheral circulation. To diagnose VWD, there are several tests that must be run including ristocetin cofactor activity, VWF antigen quantitative assay, Factor VIII activity, and collagen binding assay. Additional tests are needed to determine the subtype of VWD. The ristocetin cofactor activity can be measured using platelet aggregation or platelet agglutination. Both of these assays measure the agglutination of platelets by VWF in the presence of Ristocetin. The platelets are agglutinated when VWF combines with glycoprotein Ibα-V-IX receptors on the platelets. The agglutination causes a decrease in turbidity of the mixture and an increase of light transmitted through the test cuvette. The amount of increased light transmission correlates with the activity of the VWF. PMID: 28804849 PMID: 21186048
Source: Regenstrief LOINC
Reference Information
| Type | Source | Reference |
|---|---|---|
| Mapping Guidance | Regenstrief Help | Measures the activity of vWF protein, reported as a % of normal in the presence of Ristocetin. Mapper’s Guide for the Top 2000 plus LOINC Laboratory Observations |
Fully-Specified Name
- Component
- von Willebrand factor.ristocetin cofactor activity actual/Normal
- Property
- RelTime
- Time
- Pt
- System
- PPP
- Scale
- Qn
- Method
- Platelet aggr
Additional Names
- Short Name
- vWf:RCo Act/Nor PPP Pl Agg
- Display Name
- vWf ristocetin cofactor act actual/normal Platelet aggregation (PPP) [Relative time]
- Consumer Name Alpha Get Info
- vWf ristocetin cofactor act actual/normal, Blood
Basic Attributes
- Class
- COAG
- Type
- Laboratory
- First Released
- Version 1.0d
- Last Updated
- Version 2.73
- Change Reason
- Changed Order_Obs from 'Observation Only' to fit the current order use cases.; Updated Method from 'Aggr' to 'Platelet aggr' because the two are duplicates and 'Platelet aggr' is more commonly used in LOINC
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 2267
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 44791-2 | Menorrhagia coagulation panel - Platelet poor plasma |
| 48593-8 | von Willebrand panel - Platelet poor plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: vWF-Ristocetin Kofaktor Aktivität |
| de-DE | German (Germany) | von Willebrand-Faktor.Ristocetin Cofaktor-Aktivität aktuell/normal: |
| es-AR | Spanish (Argentina) | factor de von Willebrand.actividad del cofactor de ristocetina: |
| es-ES | Spanish (Spain) | Factor Von Willebrand. Actividad del cofactorde la ristocetina actual/normal: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Factor de von Willebrand Actividad del cofactor de ristocetina real / Normal: |
| et-EE | Estonian (Estonia) | Von Willebrandi faktor.ristotsetiini kofaktori aktiivsus tegelik/normaalne: Synonyms: Juhuslik Kvantitatiivne Suhteline aeg Trombotsüütidevaene plasma |
| fr-CA | French (Canada) | Cofacteur de la ristocétine.facteur de von Willebrand, Mesuré/normal: |
| fr-FR | French (France) | Facteur Willebrand activité cofacteur ristocétine Patient (%): |
| fr-BE | French (Belgium) | Cofacteur de la ristocétine.facteur de von Willebrand Mesuré/normal: Synonyms: Fvw Mesuré/normal |
| it-IT | Italian (Italy) | von Willebrand, fattore.attività cofattore ristocetina effettivo/normale: Synonyms: Aggregazione piastrinica Attività del cofattore ristocetina del fattore di Cofattore ristocetina del fattore di von Willebran Fattore di von Willebrand (vWf) Plasma povero di piastrine Punto nel tempo (episodio) Studio di coagulazione Tempo Relativo |
| ko-KR | Korean (Korea, Republic Of) | 폰 빌레브란트 인자.리스토세틴 보조인자 활성도 실제값/정상범위: |
| nl-NL | Dutch (Netherlands) | von Willebrand-factor.ristocetinecofactor activiteit gemeten/normaal: Synonyms: coagulatiemethode gemeten/normaal plaatjesaggregatie |
| pl-PL | Polish (Poland) | Czynnik von Willebranda.aktywność kofaktora rystocetyny badane/prawidłowe: Synonyms: Czynnik von Willebranda (vWf) Czynnik von Willebranda aktywność kofaktora rystocetyny PPP |
| pt-BR | Portuguese (Brazil) | Fator Von Willebrand.Cofator Ristocetina atividade verdadeira/Normal: Synonyms: ; |
| tr-TR | Turkish (Turkey) | von Willebrand faktörü.ristocetin kofaktör aktivitesi gerçek/normal: |
| zh-CN | Chinese (China) | von Willebrand 因子.瑞斯托菌素辅助因子活性 实际的/正常的: Synonyms: PAgT; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
| % | REGENSTRIEF |
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