72385-8

2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP) [Mass/volume] in Saliva (oral fluid) by Confirmatory method

Active

Part Descriptions

LP35885-0 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine
EDDP (2-ethylidene-1,5-dimethyl1-3,3-diphenylpyrrolidine) is a primary metabolite of methadone, a synthetic opioid used for the treatment of opioid dependence. It is excreted in bile and urine along with other another methadone metabolite, EMPD. Levels of methadone itself are variable and depend on a patient's urine pH value, dose given, and metabolism. EDDP levels are less variable and can be detected 4 to 6 hours after methadone use, therefore, EDDP is preferentially used to check for methadone exposure. Source: Regenstrief Institute

LP7565-7 Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583 Source: Regenstrief LOINC

LP262420-5 Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583 Source: Regenstrief LOINC

Fully-Specified Name

Component: 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine
Property: MCnc
Time: Pt
System: Saliva
Scale: Qn
Method: Confirm

Additional Names

Short Name: EDDP Sal Cfm-mCnc
Display Name: 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP) Confirm (Sal) [Mass/Vol]
Consumer Name Alpha Get Info: 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP), Saliva

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.42
Last Updated: Version 2.73
Order vs. Observation: Both
Common Test Rank Get Info: 9591

Member of these Panels

LOINC	Long Common Name
72476-5	Methadone panel - Saliva (oral fluid) by Confirmatory method

Member of these Groups Get Info

LOINC Group	Group Name
LG37661-2	2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine\|ANYProp\|ANYTm\|ANYSys\|ANYMeth

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	2-etilideno-1,5-dimetil-3,3-difenilpirrolidina (EDDP):Concentración de masa:Punto temporal:Saliva:Qn:Confirmatorio Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	2-etiliden-1,5-dimetil-3,3-difenilpirrolidina:Concentración de masa:Punto temporal:Saliva:Cuantitativo:Confirmar
et-EE	Estonian (Estonia)	2-etüülideen-1,5-dimetüül-3,3-difenüülpürolidiin:MCnc:Pt:Sal:Qn:Kinnitav Synonyms: Juhuslik Kvantitatiivne Sülg
fr-CA	French (Canada)	2-éthylidène-1,5-diméthyl-3,3-diphénylpyrrolidine (EDDP):Concentration de masse:Temps ponctuel:Salivaire:Quantitatif:Confirmation
fr-FR	French (France)	2-éthylidène-1,5-diméthyl-3,3-diphénylpyrrolidine:Masse/Volume:Ponctuel:Salive:Numérique:Confirmation
fr-BE	French (Belgium)	2-éthylidène-1,5-diméthyl-3,3-diphénylpyrrolidine (EDDP):Concentration de masse:Temps ponctuel:Salivaire:Quantitatif:Confirmé
it-IT	Italian (Italy)	2-Etilidene-1,5-Dimetil-3,3-Difenilpirrolidina:MCnc:Pt:Saliva:Qn:Conferma Synonyms: 2-Etilidene-1,5-Dimetil-3,3-Difenilpirrolidina (ED Concentrazione di Massa Livelli farmacologici e tossicologia Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	2-ethylideen-1,5-dimethyl-3,3-difenylpyrrolidine:massa/volume:moment:speeksel:kwantitatief:bevestiging
pt-BR	Portuguese (Brazil)	2-Etilidene-1,5-Dimetil-3,3-Difenilpirrolidine::Pt:Saliva:Qn:Confirmatório
ru-RU	Russian (Russian Federation)	2-Этилиден-1,5-Диметил-3,3-Дифенил Пирролидин:МассКонц:ТчкВрм:Слюна:Колич:Подтверждать Synonyms: Количественный Массовая концентрация Точка во времени;Момент
tr-TR	Turkish (Turkey)	2-Etiliden-1,5-Dimetil-3,3-Difenilpirrolidin:KütlKons:Zmlı:Tükürük:Kant:Onay Synonyms: Teyid
zh-CN	Chinese (China)	2-亚乙基-1,5-二甲基-3,3-四氢吡咯:质量浓度:时间点:唾液:定量型:毒理学确认试验 Synonyms: Ⅰ 2-乙叉-1,5-二甲基-3,3-吡咯烷;2-乙叉-1,5-二甲基-3,3-四氢吡咯;2-乙叉-1,5-二甲基-3,3-氮戊环;2-亚乙基-1,5-二甲基-3,3-吡咯烷;2-亚乙基-1,5-二甲基-3,3-氮戊环;美沙酮代谢产物 Ⅱ Ⅲ I II III 三叁可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间毒品毒品类水平;浓度;质量浓度(单位体积) 津;津液;涎确认方法;确认法;确认试验药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类

Example Units

Unit	Source
ng/mL	Example UCUM Units

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