Version 2.78

Term Description

Point mutations and deletions of codons D835 and I836 within the second tyrosine kinase domain (protein activation loop) of the FLT3 gene are detected by molecular genetic methods (e.g. PCR-based assays). This code was created for, but not limited to Invivoscribe's LeukoStrat(tm) FLT3 Gel Detection Mutation Assay, which detects the presence or absence of either D835 or I836 mutations within the second TKD but does not identify specific TKD mutations. FLT3-TKD mutations occur in approximately 7% of patients with acute myelogenous leukemia (AML).
Source: Regenstrief LOINC

Fully-Specified Name

Component
FLT3 gene.p.Asp835+Ile836 mutations
Property
PrThr
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
Molgen

Additional Names

Short Name
FLT3 p.D835+I836 Bld/T Ql
Display Name
FLT3 gene.p.Asp835+Ile836 mutations Molgen Ql (Bld/Tiss)
Consumer Name Alpha Get Info
FLT3 gene.p.Asp835+Ile836 mutations, Blood or tissue specimen

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.73
Change Reason
Release 2.71: COMPONENT: Changed for nomenclature consistency.; Previous Releases: Changed Component name to align with the current HGVS recommendations to use the three letter codes for amnio acids. In the shortname, we kept the single letter codes.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
5547

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: FLT3 Genmutation (Asp835+Ile836)
es-ES Spanish (Spain) Gen FLT3 pD835+I836:PrThr:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MX Spanish (Mexico) Gen FLT3 p. Asp835 + Ile836:Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-CA French (Canada) Gène FLT3.p.Asp835+Ile836, Mutations:Présence-Seuil:Temps ponctuel:Sang/Tissu:Ordinal:Molgen
fr-FR French (France) FLT3 gène p.Asp835+Ile836:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) FLT3, gene.p.Asp835+mutazioni Ile836:PrThr:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Gene FLT3 Gene FLT3 p.Asp835+mutazioni Ile836 Genetica molecolare Mutazione genica Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) FLT3 gen.p.Asp835+Ile836 mutaties:aanwezigheid:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek
Synonyms: FLT3 gen molgen
pt-BR Portuguese (Brazil) FLT3 gene.p.D835+I836::Pt:Sg/Tecido:Ord:Genética molecular
ru-RU Russian (Russian Federation) FLT3 ген.p.D835+I836:PrThr:ТчкВрм:Кр/Тк:Пор:МолГен
Synonyms: Кровь Кровь или Ткань Порядковый Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) FLT3 geni.p.D835+I836:MevcEşik:Zmlı:Kan/Dk:Srl:Molgen
Synonyms: Mevcut
zh-CN Chinese (China) FLT3 基因.p.Asp835+Ile836 突变:存在情况或阈值:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: FL 细胞因子受体前体;FLK2;fms-相关性酪氨酸激酶 3;STK1;STK-1;干细胞酪氨酸激酶 1 FLT3 基因.p.D835+I836 突变 P 型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 突变 突变类;基因突变 血;血液 遗传基因;遗传因子;吉恩;生物基因

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72520-0