72880-8
Deprecated CYP2D6 gene drug metabolism analysis overall interpretation [Interpretation] in Blood, Tissue or Saliva Qualitative by Molecular genetics method
Deprecated
Status Information
- Status
- DEPRECATED
- Reason
- Duplicate
| Map-To | Long Common Name | Mapping Guidance |
|---|---|---|
| 79715-9 | CYP2D6 gene product metabolic activity interpretation in Blood or Tissue Qualitative by Molecular genetics method |
Term Description
Overall predicted phenotype for drug metabolism for all markers and/or individual CYP2D6 alleles identified in a patient. The predicted phenotypes are derived from reference literature.
Source: Regenstrief LOINC
Part Description
LP19693-8 CYP2D6 gene
The CYP2D6 gene (cytochrome P450, family 2, subfamily D, polypeptide 6) [HGNC Gene ID:2625] is located on chromosome 22q13.1. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] [NCBI Gene ID:1565]
Source: National Center for Biotechnology Information (NCBI) Gene
Fully-Specified Name
- Component
- CYP2D6 gene drug metabolism analysis overall interpretation
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss/Sal
- Scale
- Ord
- Method
- Molgen
Additional Names
- Short Name
- Deprecated CYP2D6 drg metab interp Bld/T/S-Imp
- Display Name
- CYP2D6 gene drug metabolism analysis overall interpretation Molgen Ql (Bld/Tiss/Sal) [Interp]
- Consumer Name Alpha Get Info
- CYP2D6 gene drug metabolism interpretation
Example Answer List: LL605-7
Source: Regenstrief LOINC| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Ultrarapid metabolizer | LA10315-2 | ||
| Extensive metabolizer | LA10316-0 | ||
| Intermediate metabolizer | LA10317-8 | ||
| Poor metabolizer | LA9657-3 | ||
| InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value) | LA9663-1 | ||
| Failure | LA9664-9 |
Basic Attributes
- Class
- MOLPATH.MUT
- Type
- Laboratory
- First Released
- Version 2.44
- Last Updated
- Version 2.67
- Change Reason
- Corrected Scale from "Nom" to "Ord" since results are ordinal.
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Gen CYP2D6 Interpretación total del metabolismo de drogas: |
| es-MX | Spanish (Mexico) | Interpretación general del análisis del metabolismo de fármacos del gen CYP2D6: |
| fr-FR | French (France) | CYP2D6 gène métabolisme des médicaments interprétation globale: |
| it-IT | Italian (Italy) | CYP2D6, gene, farmaci, interpretazione complessiva analisi metabolismo: Synonyms: Gene CYP2D6 Genetica molecolare Impressione/interpretazione di studio Interpretazione complessiva di analisi del metabol Mutazione genica Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Sangue, Tessuto o Saliva Tessuto & |
| pt-BR | Portuguese (Brazil) | CYP2D6 gene análise do metabolismo de drogas interpretação global: |
| ru-RU | Russian (Russian Federation) | CYP2D6 ген наркотик метаболизм анализ общая интерпретация: Synonyms: Впечатление/интерпретация исследования Кровь Кровь или Ткань Кровь, Ткань или Слюна лекарства метаболизма анализ общая интерпретация Наркотик Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | CYP2D6 geni ilaç metabolizması analizi tüm değerlendirilme: Synonyms: KISALTILMIŞINA BAK |
| zh-CN | Chinese (China) | CYP2D6 基因 药物代谢分析总体解释: Synonyms: CPD6; |
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