72886-5
CYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method
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40425-1 CYP2D6 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
Term Description
The patient's CYP2D6 allelic genotype (e.g. *1/*2A) based on analysis of multiple variants (e.g. *2,*2A,*3-*12,*14,*15,*17,*19, etc.) as well as gene deletions, duplications and rearrangements within the CYP2D6 gene. The example answers provided with this code are a small representative of the CYP2D6 allelic genotypes. For a complete list of CYP2D6 alleles, see the The Human Cytochrome P450 (CYP) Allele Nomenclature Database (http://www.cypalleles.ki.se).
Source: Regenstrief LOINC
Part Descriptions
LP417569-3 CYP2D6 gene allele
Cytochrome P450-2D6 (CYP2D6;[HGNC Gene ID: 2625]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism approximately 25% of drugs in current clinical use. Genetic variations in CYP2D6 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP2D6 and selection of alternative dosing or agents may be necessary in individuals with specific CYP2D6 genetic variations. PMID: 23486447 PMID: 24458010 PMID: 25974703. See https://www.pharmgkb.org/gene/PA128 for more information and dosing guidelines for drugs impacted by CYP2D6 genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- CYP2D6 gene allele
- Property
- Geno
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nom
- Method
- Molgen
Additional Names
- Panel Name
- Short Name
- CYP2D6 allele Geno Bld/T
- Display Name
- CYP2D6 gene allele genotype Molgen (Bld/Tiss)
- Consumer Name Alpha Get Info
- CYP2D6 gene allele genotype, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.15
- Last Updated
- Version 2.73
- Change Reason
- Release 2.68: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; COMPONENT: Updated Component to align with the LOINC term naming model for concepts used to report allelic genotypes (e.g. CYP2D6*1/*1), which was the original intent for this term.; Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; Previous Releases: Added specimen of saliva since Cytochrome P450 gene testing is commonly done on saliva as well as blood specimens and results are theoretically the same for both.; Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 9273
Example Answer List LL5517-9
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| CYP2D6*1A/*4X2 | LA30687-0 | ||
| CYP2D6*1A/*1B | LA30688-8 | ||
| CYP2D6*1A/*1C | LA30689-6 | ||
| CYP2D6*1C/*6B | LA30690-4 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72886-5 | CYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Alelo del gen CYP2D6: |
| es-ES | Spanish (Spain) | Alelo del gen CYP2D6: |
| fr-FR | French (France) | CYP2D6 gène allèle: |
| it-IT | Italian (Italy) | CYP2D6, gene allele: Synonyms: Farmacogenomica Gene CYP2D6 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| ko-KR | Korean (Korea, Republic Of) | CYP2D6 유전자 돌연변이 분석: |
| nl-NL | Dutch (Netherlands) | CYP2D6-allel: Synonyms: CYP2D6 gen molgen |
| pt-BR | Portuguese (Brazil) | CYP2D6 análise de mutação genética: Synonyms: Cytochrome p450; |
| zh-CN | Chinese (China) | CYP2D6 基因等位基因: Synonyms: CPD6; |
79715-9 CYP2D6 gene product metabolic activity interpretation in Blood or Tissue Qualitative by Molecular genetics method
Term Description
The CYP2D6 gene product metabolic activity interpretation is determined by the reporting lab and returned with the structured test results. The Preferred Answer list associated with this term is based on the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for reporting CYP2D6 gene product metabolic activity (phenotype), which apply to both genetic and enzymatic assays (this LOINC term represents a genetic assay). This specific interpretation would be considered a separate observation made by the lab in addition to the primary reported results (e.g., genotype or measured activity level) and it could be included with other assay-specific observations, which would ideally support the interpretation value. [https://cpicpgx.org/resources.html]
Source: Regenstrief LOINC
Part Descriptions
LP202919-9 CYP2D6 gene product metabolic activity interpretation
Cytochrome P450-2D6 (CYP2D6;[HGNC Gene ID: 2625]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism approximately 25% of drugs in current clinical use. Genetic variations in CYP2D6 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP2D6 and selection of alternative dosing or agents may be necessary in individuals with specific CYP2D6 genetic variations. PMID: 23486447 PMID: 24458010 PMID: 25974703. See https://www.pharmgkb.org/gene/PA128 for more information and dosing guidelines for drugs impacted by CYP2D6 genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- CYP2D6 gene product metabolic activity interpretation
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
- Molgen
Additional Names
- Panel Name
- Short Name
- CYP2D6 gene prod met act imp Bld/T-Imp
- Display Name
- CYP2D6 gene product metabolic activity interpretation Molgen Ql (Bld/Tiss) [Interp]
- Consumer Name Alpha Get Info
- CYP2D6 gene product metabolic activity interpretation, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 13971
Preferred Answer List LL3856-3
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Ultrarapid metabolizer | LA10315-2 | ||
| Rapid metabolizer | LA25390-8 | ||
| Normal metabolizer | LA25391-6 | ||
| Intermediate metabolizer | LA10317-8 | ||
| Poor metabolizer | LA9657-3 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72886-5 | CYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Interpretación de la actividad metabólica del producto del gen CYP2D6: |
| es-ES | Spanish (Spain) | Gen CYP2D6 interpretation de la actividad en el metabolismo de fármacos: |
| fr-FR | French (France) | CYP2D6 gène activité métabolique interprétation: |
| it-IT | Italian (Italy) | Interpretazione dell'attività metabolica del gene CYP2D6: Synonyms: Farmacogenomica Gene CYP2D6 Genetica molecolare Impressione/interpretazione di studio Interpretazione dell''attività metabolica del gene Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | CYP2D6-gen product metabole activiteit interpretatie: Synonyms: CYP2D6 gen CYP2D6 gen product metabole activiteit interpretatie molgen |
| tr-TR | Turkish (Turkey) | CYP2D6 geni ürünü metabolik aktivite yorumu: |
| zh-CN | Chinese (China) | CYP2D6 基因产物新陈代谢活性解释: Synonyms: CPD6; |
57132-3 CYP2C19 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
Term Description
A patient's allelic genotype (e.g. *1/*12) at the CYP2C19 gene locus to determine CYP2C19 enzyme activity. Genotype results may be used to determine a patient's drug dose adjustment.
Source: Regenstrief LOINC
Part Descriptions
LP417567-7 CYP2C19 gene allele
Cytochrome P450-2C19 (CYP2C19; [HGNC Gene ID: 2621]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism 10-15% of drugs in current clinical use. Genetic variations in CYP2C19 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP2C19 and selection of alternative dosing or agents may be necessary in individuals with specific CYP2C19 genetic variations. PMID: 23486447 PMID: 23698643 PMID: 25974703 See https://www.pharmgkb.org/gene/PA124 for more information and dosing guidelines for drugs impacted by CYP2C19 genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- CYP2C19 gene allele
- Property
- Geno
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nom
- Method
- Molgen
Additional Names
- Panel Name
- Short Name
- CYP2C19 allele Geno Bld/T
- Display Name
- CYP2C19 gene allele genotype Molgen (Bld/Tiss)
- Consumer Name Alpha Get Info
- CYP2C19 gene allele genotype, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.29
- Last Updated
- Version 2.73
- Change Reason
- Release 2.68: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; COMPONENT: Updated Component to align with the LOINC term naming model for concepts used to report allelic genotypes (e.g. CYP2C19*1/*12 ), which was the original intent for this term.; Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; SYSTEM: Updated System from "Bld/Tiss/Sal" to "Bld/Tiss" since this System in LOINC encompasses all specimens used for germline nucleic acid testing, including blood, tissue and cells contained in swabs as well as fluids such as saliva.; Previous Releases: Added specimen of saliva since Cytochrome P450 gene testing is commonly done on saliva as well as blood specimens and results are theoretically the same for both.; Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 7198
Example Answer List LL950-7
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| CYP2C19*1/*1 | LA13515-4 | ||
| CYP2C19*1/*2 | LA13516-2 | ||
| CYP2C19*1/*3 | LA13517-0 | ||
| CYP2C19*2/*2 | LA13518-8 | ||
| CYP2C19*2/*3 | LA13519-6 | ||
| CYP2C19*3/*3 | LA13520-4 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72886-5 | CYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: CYP2C19 Genotyp. |
| es-MX | Spanish (Mexico) | Alelo del gen CYP2C19: |
| es-ES | Spanish (Spain) | Alelo del gen CYP2C19: |
| fr-FR | French (France) | CYP2C19 gène allèle: |
| it-IT | Italian (Italy) | CYP2C19, gene allele: Synonyms: Farmacogenomica Gene CYP2C19 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | CYP2C19-allel: Synonyms: CYP2C19 gen molgen |
| pt-BR | Portuguese (Brazil) | CYP2C19 análise de mutação do gene: Synonyms: cytochrome P-450 II C; |
| zh-CN | Chinese (China) | CYP2C19 基因等位基因: Synonyms: Cytochrome P450, family 2, subfamily C, polypeptide 19; |
79714-2 CYP2C19 gene product metabolic activity interpretation in Blood or Tissue Qualitative by Molecular genetics method
Term Description
The CYP2C19 gene product metabolic activity interpretation is determined by the reporting lab and returned with the structured test results. The Preferred Answer list associated with this term is based on the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for reporting CYP2C19 gene product metabolic activity (phenotype), which apply to both genetic and enzymatic assays (this LOINC term represents a genetic assay). This specific interpretation would be considered a separate observation made by the lab in addition to the primary reported results (e.g., genotype or measured activity level) and it could be included with other assay-specific observations, which would ideally support the interpretation value. [https://cpicpgx.org/resources.html]
Source: Regenstrief LOINC
Part Descriptions
LP202918-1 CYP2C19 gene product metabolic activity interpretation
Cytochrome P450-2C19 (CYP2C19; [HGNC Gene ID: 2621]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism 10-15% of drugs in current clinical use. Genetic variations in CYP2C19 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP2C19 and selection of alternative dosing or agents may be necessary in individuals with specific CYP2C19 genetic variations. PMID: 23486447 PMID: 23698643 PMID: 25974703 See https://www.pharmgkb.org/gene/PA124 for more information and dosing guidelines for drugs impacted by CYP2C19 genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- CYP2C19 gene product metabolic activity interpretation
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
- Molgen
Additional Names
- Panel Name
- Short Name
- CYP2C19 gene prod met act imp Bld/T-Imp
- Display Name
- CYP2C19 gene product metabolic activity interpretation Molgen Ql (Bld/Tiss) [Interp]
- Consumer Name Alpha Get Info
- CYP2C19 gene product metabolic activity interpretation, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 10495
Preferred Answer List LL3856-3
| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Ultrarapid metabolizer | LA10315-2 | ||
| Rapid metabolizer | LA25390-8 | ||
| Normal metabolizer | LA25391-6 | ||
| Intermediate metabolizer | LA10317-8 | ||
| Poor metabolizer | LA9657-3 |
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 72886-5 | CYP2D6 gene and CYP2C19 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Interpretación de la actividad metabólica del producto del gen CYP2C19: |
| es-ES | Spanish (Spain) | Gen CYP2C19 interpretation de la actividad en el metabolismo de fármacos: |
| fr-FR | French (France) | CYP2C19 gène activité métabolique interprétation: |
| it-IT | Italian (Italy) | Interpretazione dell'attività metabolica del gene CYP2C19: Synonyms: Farmacogenomica Gene CYP2C19 Genetica molecolare Impressione/interpretazione di studio Interpretazione dell''attività metabolica del gene Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | CYP2C19-gen product metabole activiteit interpretatie: Synonyms: CYP2C19 gen CYP2C19 gen product metabole activiteit interpretatie molgen |
| tr-TR | Turkish (Turkey) | CYP2C19 geni ürünü metabolik aktivite yorumu: |
| zh-CN | Chinese (China) | CYP2C19 基因产物新陈代谢活性解释: Synonyms: CYP2C19 基因产物新陈代谢（代谢）活性解释（说明、 |