Version 2.78

Part Description

LP33048-7   Perforin
Perforin-1 is a protein that in humans is encoded by the PRF1 gene.

Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.

Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria.

Although purified perforin is sufficient to lyse cells at high doses, the biology of perforin itself does not explain the ability of CD8 T-cells and NK cells to induce apoptosis in target cells. This induction of apoptosis may require at least one other granule protein, granzyme B. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Perforin Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
Perforin Ag Tiss Ql ImStn
Display Name
Perforin Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
Perforin antigen, Tissue

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Perforina Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Perforin Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
et-EE Estonian (Estonia) Perforiin antigeen:PrThr:Pt:Tis:Ord:Immuunvärv
Synonyms: Järgarvuline Juhuslik Kude
fr-CA French (Canada) Perforine, Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FR French (France) Perforine antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
fr-BE French (Belgium) Perforine Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
Synonyms: Antigène Coloration. Méthode mmunologique
it-IT Italian (Italy) Perforina, Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) perforine Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
Synonyms: antigeen
pt-BR Portuguese (Brazil) Perforina Ag::Pt:Tecido:Ord:Imunocoloração
ru-RU Russian (Russian Federation) Перфорин Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) Perforin Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama
Synonyms: Antijen Mevcut
zh-CN Chinese (China) 穿孔素 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: Ag Perforin;PFN;PFP;穿孔素（Pore-Forming Protein，Perforin，PFN，PFP） 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74121-5