Version 2.78

14946-8 Valproate [Moles/volume] in Serum or Plasma

Part Descriptions

LP16305-2   Valproate
Valproic acid is a compound used as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, juvenile myoclonic epilepsy and the seizures associated with Lennox-Gastaut syndrome. It is also used in treatment of myoclonus. In some countries, parenteral (administered intravenously) preparations of valproate are used also as second-line treatment of status epilepticus, alternatively to phenytoin. Related drugs include sodium valproate, used as an anticonvulsant, and a combined formulation, valproate semi-sodium, used as a mood stabilizer and anticonvulsant. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Valproate (Wikipedia)

LP16305-2   Valproate
Valproic acid is an anticonvulsant that is used alone or with other medication to treat certain types of seizures, mania in people with bipolar disorder, and to prevent migranes before they occur. it cannot be used to treat migranes once they begin.
Valproic acid can also be used for children with attention deficit hyperactivity disorder to treat outbursts of aggression or impaired intellectual functioning, developmental delays, and behavioral disturbances associated with Lennoz-Gastaut syndrome.[MedlinePlus Drug:a682412][NINDS:Disorders/All-Disorders/Lennox-Gastaut-Syndrome-Information-Page] Source: Regenstrief LOINC

Fully-Specified Name

Component
Valproate
Property
SCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Valproate SerPl-sCnc
Display Name
Valproate [Moles/Vol]
Consumer Name Alpha Get Info
Valproate, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0k
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
11524

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets

Member of these Groups Get Info

LOINC Group Group Name
LG49789-7 Valproate|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Valproat:Stoffmengenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
Synonyms: Valproinsäure
de-AT German (Austria) Synonyms: Valproinsäure
el-GR Greek (Greece) Βαλπροϊκό:Συγκέντρωση ουσίας:Χρονική στιγμή:Ορός/Πλάσμα:Ποσοτική:
es-AR Spanish (Argentina) valproato:concentración de sustancia:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Valproato:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat:SCnc:Pt:S/P:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Valproato:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Sostanza Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 벨프로에이트:물질농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) valproaat:mol/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Valproato:SCnc:Pt:Sor/Plas:Qn:
Synonyms: Valproic acid; Depakene; Substance concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Вальпроат:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproat:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 2-丙基戊酸:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
umol/L Example UCUM Units
umol/L eCHN

18489-5 Valproate.protein bound [Mass/volume] in Serum or Plasma

Fully-Specified Name

Component
Valproate.protein bound
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
PB Valproate SerPl-mCnc
Display Name
Valproate.protein bound [Mass/Vol]
Consumer Name Alpha Get Info
Valproate.protein bound, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0l
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
9436

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) valproato.unido a proteínas:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Proteína de unión a Ácido Valproico:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato unido a proteína:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat.valguga seotud:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate.lié aux protéines:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate protéine liée:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate.lié aux protéines:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Valproato.proteina legato:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 단백 결합 벨프로에이트:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) valproaat.eiwit gebonden:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Valproato.ligado a proteína:MCnc:Pt:Sor/Plas:Qn:
Synonyms: ; PB Valproate; Valproic acid; Depakene; Prot; PR; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; bnd; Associated; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Вальпроат.протеин связанный:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Белок Вальпроат, связанный с белком Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproate.proteine bağlı:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 2-丙基戊酸.蛋白质结合型:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸.蛋白结合型;蛋白结合型 2-丙基戊酸;蛋白质结合型 2-丙基戊酸 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ug/mL Example UCUM Units

21590-5 Valproate.bound/Valproate.total in Serum or Plasma

Fully-Specified Name

Component
Valproate.bound/Valproate.total
Property
MFr
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Valproate Bnd MFr SerPl
Display Name
Valproate.bound/Total valproate [Mass fraction]
Consumer Name Alpha Get Info
Valproate.bound/Valproate.total, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0m
Last Updated
Version 2.73
Order vs. Observation
Observation
Common Test Rank Get Info
9471

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) valproato.unido/valproato.total:fracción de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Valproato ligado/Valproato total:Fracción de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato.bound / Valproato.total:Fracción de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat.seotud/valproaat.üld:MFr:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate.lié/Valproate.totale:Fraction de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate lié/valproate total:Fraction massique:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate.lié/Valproate.totale:Fraction de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Valproato.legato/Valproato.totale:MFr:Pt:Siero/Plasma:Qn:
Synonyms: Frazione di massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 결합벨프로에이트/총벨프로에이트:질량분획:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) valproaat.gebonden/valproaat.totaal:massafractie:moment:serum of plasma:kwantitatief:
Synonyms: valproinezuur; 2-propylpentaanzuur
pt-BR Portuguese (Brazil) Valproato.ligado/Valproato.total:MFr:Pt:Sor/Plas:Qn:
Synonyms: ; Valproate Bnd; Valproic acid; Depakene; Mass fraction; Percent; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; Tot; Totl; bnd; Associated; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Вальпроат.связанный/Вальпроат.общий:МассДол:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая доля Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproate.bağlı/Valproat.total:KütlFr:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 2-丙基戊酸.结合型/2-丙基戊酸.总计:质量分数:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸.结合;结合型 2-丙基戊酸 2-丙基戊酸总计 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid MFr 全体数量 全部 共计 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总量 总额 时刻;随机;随意;瞬间 毒品 毒品类 汇总 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
% Example UCUM Units

32119-0 Valproate Free [Moles/volume] in Serum or Plasma

Part Descriptions

LP207910-3   free DRUG/TOX
The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug PMID: 6636249. For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity. Source: Regenstrief LOINC

Fully-Specified Name

Component
Valproate.free
Property
SCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Valproate Free SerPl-sCnc
Display Name
Valproate Free [Moles/Vol]
Consumer Name Alpha Get Info
Free valproate, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.07
Last Updated
Version 2.70
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets

Member of these Groups Get Info

LOINC Group Group Name
LG47174-4 Valproate.free|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) valproato.libre:concentración de sustancia:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Valproico libre:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato.libre:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat.vaba:SCnc:Pt:S/P:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate.libre:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate libre:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate.libre:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Valproato.libero:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Sostanza Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma Valproato Libero
ko-KR Korean (Korea, Republic Of) 유리벨프로에이트:물질농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) valproaat.vrije:mol/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Valproato.livre:SCnc:Pt:Sor/Plas:Qn:
Synonyms: Valproic acid; Depakene; Substance concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; FR; Non-protein bound; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Вальпроат.свободный:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproat.serb:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 2-丙基戊酸.游离型:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸.游离;游离 2-丙基戊酸;游离型 2-丙基戊酸 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 游离 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆 非蛋白结合型 非蛋白质结合型

Example Units

Unit Source
umol/L Example UCUM Units
umol/L eCHN

32283-4 Valproate Free/Valproate.total in Serum or Plasma

Part Descriptions

LP207910-3   free DRUG/TOX
The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug PMID: 6636249. For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity. Source: Regenstrief LOINC

Fully-Specified Name

Component
Valproate.free/Valproate.total
Property
MFr
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Valproate Free MFr SerPl
Display Name
Valproate Free/Total valproate [Mass fraction]
Consumer Name Alpha Get Info
Free valproate/Valproate.total, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.07
Last Updated
Version 2.73
Order vs. Observation
Observation
Common Test Rank Get Info
5529

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) valproato.libre/valproato.total:fracción de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Valproico libre/Valproato total:Fracción de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato.libre/Valproato.total:Fracción de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat.vaba/valproaat.üld:MFr:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate.libre/Valproate.totale:Fraction de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate libre/valproate total:Fraction massique:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate.libre/Valproate.totale:Fraction de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Valproato.libero/Valproato.totale:MFr:Pt:Siero/Plasma:Qn:
Synonyms: Frazione di massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma Valproato Libero
ko-KR Korean (Korea, Republic Of) 유리벨프로에이트/총벨프로에이트:질량분획:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) valproaat.vrije/valproaat.totaal:massafractie:moment:serum of plasma:kwantitatief:
Synonyms: valproinezuur; 2-propylpentaanzuur
pt-BR Portuguese (Brazil) Valproato.livre/Valproato.total:MFr:Pt:Sor/Plas:Qn:
Synonyms: Valproic acid; Depakene; Mass fraction; Percent; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; Tot; Totl; FR; Non-protein bound; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Вальпроат.свободный/Вальпроат.общий:МассДол:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая доля Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproat.serb/Valproat.total:KütlFr:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 2-丙基戊酸.游离型/2-丙基戊酸.总计:质量分数:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸.游离;游离 2-丙基戊酸;游离型 2-丙基戊酸 2-丙基戊酸总计 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid MFr 全体数量 全部 共计 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 总 总和 总数 总量 总额 时刻;随机;随意;瞬间 毒品 毒品类 汇总 游离 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆 非蛋白结合型 非蛋白质结合型

Example Units

Unit Source
% Example UCUM Units
% REGENSTRIEF

4086-5 Valproate [Mass/volume] in Serum or Plasma

Part Descriptions

LP16305-2   Valproate
Valproic acid is a compound used as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, juvenile myoclonic epilepsy and the seizures associated with Lennox-Gastaut syndrome. It is also used in treatment of myoclonus. In some countries, parenteral (administered intravenously) preparations of valproate are used also as second-line treatment of status epilepticus, alternatively to phenytoin. Related drugs include sodium valproate, used as an anticonvulsant, and a combined formulation, valproate semi-sodium, used as a mood stabilizer and anticonvulsant. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Valproate (Wikipedia)

LP16305-2   Valproate
Valproic acid is an anticonvulsant that is used alone or with other medication to treat certain types of seizures, mania in people with bipolar disorder, and to prevent migranes before they occur. it cannot be used to treat migranes once they begin.
Valproic acid can also be used for children with attention deficit hyperactivity disorder to treat outbursts of aggression or impaired intellectual functioning, developmental delays, and behavioral disturbances associated with Lennoz-Gastaut syndrome.[MedlinePlus Drug:a682412][NINDS:Disorders/All-Disorders/Lennox-Gastaut-Syndrome-Information-Page] Source: Regenstrief LOINC

Fully-Specified Name

Component
Valproate
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Valproate SerPl-mCnc
Display Name
Valproate [Mass/Vol]
Consumer Name Alpha Get Info
Valproate, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
595

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets
55427-9 Seizure disorder tracking panel
57775-9 Valproate.free and Valproate panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG49789-7 Valproate|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Valproinsäure
de-DE German (Germany) Valproat:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
Synonyms: Valproinsäure
el-GR Greek (Greece) Βαλπροϊκό:Συγκέντρωση μάζας:Χρονική στιγμή:Ορός/Πλάσμα:Ποσοτική:
es-AR Spanish (Argentina) valproato:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Valproato:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Valproato:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 벨프로에이트:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) valproaat:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Valproato:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Valproic acid; Depakene; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Вальпроат:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproat:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 2-丙基戊酸:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ug/mL Example UCUM Units
mcg/mL REGENSTRIEF

4087-3 Valproate Free [Mass/volume] in Serum or Plasma

Part Descriptions

LP207910-3   free DRUG/TOX
The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug PMID: 6636249. For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity. Source: Regenstrief LOINC

Fully-Specified Name

Component
Valproate.free
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Valproate Free SerPl-mCnc
Display Name
Valproate Free [Mass/Vol]
Consumer Name Alpha Get Info
Free valproate, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73
Change Reason
Order_Obs: changed from 'observation' to 'both' to reflect that the LOINC code can also be used as an order code.
Order vs. Observation
Both
Common Test Rank Get Info
1810

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets
57775-9 Valproate.free and Valproate panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG47174-4 Valproate.free|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
es-AR Spanish (Argentina) valproato.libre:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Valproico libre:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato.libre:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat.vaba:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate.libre:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate libre:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate.libre:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Valproato.libero:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma Valproato Libero
ko-KR Korean (Korea, Republic Of) 유리벨프로에이트:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) valproaat.vrije:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Valproato.livre:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Valproic acid; Depakene; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; FR; Non-protein bound; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Вальпроат.свободный:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproat.serb:KütlKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 2-丙基戊酸.游离型:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸.游离;游离 2-丙基戊酸;游离型 2-丙基戊酸 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 游离 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆 非蛋白结合型 非蛋白质结合型

Example Units

Unit Source
ug/mL Example UCUM Units
mcg/mL REGENSTRIEF

4088-1 Valproate [Mass/volume] in Serum or Plasma --trough

Part Descriptions

LP16305-2   Valproate
Valproic acid is a compound used as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, juvenile myoclonic epilepsy and the seizures associated with Lennox-Gastaut syndrome. It is also used in treatment of myoclonus. In some countries, parenteral (administered intravenously) preparations of valproate are used also as second-line treatment of status epilepticus, alternatively to phenytoin. Related drugs include sodium valproate, used as an anticonvulsant, and a combined formulation, valproate semi-sodium, used as a mood stabilizer and anticonvulsant. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Valproate (Wikipedia)

LP16305-2   Valproate
Valproic acid is an anticonvulsant that is used alone or with other medication to treat certain types of seizures, mania in people with bipolar disorder, and to prevent migranes before they occur. it cannot be used to treat migranes once they begin.
Valproic acid can also be used for children with attention deficit hyperactivity disorder to treat outbursts of aggression or impaired intellectual functioning, developmental delays, and behavioral disturbances associated with Lennoz-Gastaut syndrome.[MedlinePlus Drug:a682412][NINDS:Disorders/All-Disorders/Lennox-Gastaut-Syndrome-Information-Page] Source: Regenstrief LOINC

LP20176-1   trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Trough levels for therapeutic drug monitoring

Fully-Specified Name

Component
Valproate^trough
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Valproate Trough SerPl-mCnc
Display Name
Valproate trough [Mass/Vol]
Consumer Name Alpha Get Info
Valproate trough, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
16623

Member of these Panels

LOINC Long Common Name
54037-7 HEDIS 2009 panel
57820-3 HEDIS 2010 panel
60442-1 HEDIS 2011 panel
67767-4 HEDIS 2012 panel
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Valproat^TDM Tal:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
Synonyms: Valproinsäure
el-GR Greek (Greece) Βαλπροϊκό^κατώτερα επίπεδα:Συγκέντρωση μάζας:Χρονική στιγμή:Ορός/Πλάσμα:Ποσοτική:
es-AR Spanish (Argentina) valproato^concentración mínima [valle]:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-ES Spanish (Spain) Valproato^Valle monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato ^ comedero:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat^baas:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate^Creux:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate taux résiduel:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate^Creux:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: Minimum, nadir
it-IT Italian (Italy) Valproato^valore minimo:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM
ko-KR Korean (Korea, Republic Of) 벨프로에이트^최저 약물 농도 시간:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) valproaat^dalspiegel:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Valproato^basal:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Valproic acid; Depakene; Pre; Predose; Pre-dose; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Вальпроат^остаточная концентрация:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация минимум концентрации Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproat^en düşük:KütlKons:Zmlı:Ser/Plaz:Kant:
Synonyms: çukur düzey
zh-CN Chinese (China) 2-丙基戊酸^波谷:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid 一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ug/mL Example UCUM Units

73677-7 Valproate [Mass/volume] in Serum or Plasma --peak

Term Description

Peak levels of valproic acid are measured to monitor monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures. Peak levels in the blood are reached in approximately 2 hours and, in some cases, the peak level is more than double the trough level.
Source: Regenstrief LOINC

Part Descriptions

LP16305-2   Valproate
Valproic acid is a compound used as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, juvenile myoclonic epilepsy and the seizures associated with Lennox-Gastaut syndrome. It is also used in treatment of myoclonus. In some countries, parenteral (administered intravenously) preparations of valproate are used also as second-line treatment of status epilepticus, alternatively to phenytoin. Related drugs include sodium valproate, used as an anticonvulsant, and a combined formulation, valproate semi-sodium, used as a mood stabilizer and anticonvulsant. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Valproate (Wikipedia)

LP16305-2   Valproate
Valproic acid is an anticonvulsant that is used alone or with other medication to treat certain types of seizures, mania in people with bipolar disorder, and to prevent migranes before they occur. it cannot be used to treat migranes once they begin.
Valproic acid can also be used for children with attention deficit hyperactivity disorder to treat outbursts of aggression or impaired intellectual functioning, developmental delays, and behavioral disturbances associated with Lennoz-Gastaut syndrome.[MedlinePlus Drug:a682412][NINDS:Disorders/All-Disorders/Lennox-Gastaut-Syndrome-Information-Page] Source: Regenstrief LOINC

Fully-Specified Name

Component
Valproate^peak
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
Valproate Peak SerPl-mCnc
Display Name
Valproate peak [Mass/Vol]
Consumer Name Alpha Get Info
Valproate Peak, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.44
Last Updated
Version 2.44
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
74234-6 HEDIS 2014 Value Sets

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Valproato^Pico monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Valproato ^ pico:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Valproaat^tipp:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Valproate^Pic:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Valproate pic:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Valproate^Pic:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Valproato^picco:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Picco TDM Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) valproaat^piek:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Valproato^pico::Pt:Soro/Plas:Qn:
ru-RU Russian (Russian Federation) Вальпроат^пик:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Valproat^tepe:KütlKons:Zmlı:Ser/Plaz:Kant:
Synonyms: pik
zh-CN Chinese (China) 2-丙基戊酸^波峰:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 2-丙基戊酸钠;C8H15NaO2;丙基戊酸;丙戊酸;VPA;Valproate;Valproic Acid 一剂药物的后剂量(Postdose);剂量药物的后剂量(Postdose);后剂量(Postdose);峰值;曲线上的最大值;最高点;治疗药物监测 - 波峰 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ug/mL Example UCUM Units