Version 2.80

Term Description

Interferon gamma release assays (IGRAs) are used for the detection of M. tuberculosis. This panel was created for, but not limited in use to, Oxford Immunotec's T-SPOT.TB assay, which uses enzyme-linked immunospot (ELISPOT) methodology to enumerate M. tuberculosis-sensitized T cells by capturing interferon-gamma (IFN-y) in the vicinity of T cells in the patient's whole blood. Cells are spun and, using the ficoll centrifugation procedure, the polys and RBCs layer together in the bottom fraction with peripheral blood mononuclear cells (PBMCs) in the middle. The PBMCs are pipetted out to yield about 250,000 PBMCs per aliquot. They are incubated with M. tuberculosis specific antigens (ESAT-6, CFP10) in two separate wells, a phytohemagglutinin (PHA) control (a mitogenic stimulator) in another well, and a negative control in a fourth well. Incubation with the antigens allows for stimulation of any sensitized T cells present. Evaluating the number of antigen incubated spots compared to the positive and negative control spots provides a measurement of the abundance of M. tuberculosis sensitive T cells in the patient's blood.

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
74281-7 Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood
Indent74280-9 Mitogen stimulated gamma interferon positive control spot count [#] in Blood {#}
Indent74279-1 Gamma interferon negative control spot count [#] in Blood {#}
Indent74278-3 Mycobacterium tuberculosis stimulated gamma interferon ESAT-6 Ag spot count [#] in Blood {#}
Indent74277-5 Mycobacterium tuberculosis stimulated gamma interferon CFP10 Ag spot count [#] in Blood {#}
Indent71773-6 Mycobacterium tuberculosis stimulated gamma interferon [Interpretation] in Blood Qualitative

Fully-Specified Name

Component
Mycobacterium tuberculosis stimulated gamma interferon & spot count panel
Property
-
Time
Pt
System
Bld
Scale
-
Method

Additional Names

Long Common Name
Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood
Short Name
M TB IFN-g+spot Pnl Bld
Display Name
M. tuberculosis stim IFN-g and spot count panel (Bld)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis stimulated gamma interferon & spot count panel, Blood

Basic Attributes

Class
PANEL.MICRO
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.64 (MIN)
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: M.tuberculosis stim. IFN-G Spot-Test /Blut
el-GR Greek (Greece) Πίνακας ιντερφερόνης-γ διέγερμένης με Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) & μέτρησης κηλίδων:-:Pt:Αίμα:-:
Synonyms: Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη Ιντερφερόνη Πίνακας ιντερφερόνης-γ διέγερμένης με Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) & μέτρησης κηλίδων
es-ES Spanish (Spain) Mycobacterium tuberculosis estimulado con interferón gamma y panel de recuento de manchas:Propiedades mixtas (sólo paneles):Punto temporal:Sangre:-:
es-MX Spanish (Mexico) Panel de recuento de puntos e interferón gamma estimulado por Mycobacterium tuberculosis:-:Punto temporal:Sangre:-:
fr-FR French (France) Interféron gamma stimulé par mycobacterium tuberculosis et spots comptés panel:-:Ponctuel:Sang:-:
it-IT Italian (Italy) Mycobacterium tuberculosis, gamma interferone stimolato & numero di spot, panel:-:Pt:Sangue:-:
Synonyms: Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Panel gamma interferone stimolato da Mycobacterium tuberculosis e numero di spot Punto nel tempo (episodio) Sangue Set di prescrizione microbiologia
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis-gestimuleerde gamma-interferon en spot count panel:-:moment:bloed:-:
pt-BR Portuguese (Brazil) Mycobacterium tuberculosis gama interferon estimulada & contagem local painel::Pt:SgTotal:-:
ru-RU Russian (Russian Federation) Mycobacterium tuberculosis стимулированный гамма интерферон & пятно количество панель:-:ТчкВрм:Кр:-:
Synonyms: Кровь Точка во времени;Момент
zh-CN Chinese (China) 结核分枝杆菌刺激型 gamma 干扰素与斑点计数组套:-:时间点:全血:-:
Synonyms: AFB IFN 分支杆菌 分支杆菌属 分枝杆菌属 劳瘵 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.微生物学;实验室组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）类.微生物学试验;医嘱组.微生物学试验;医嘱组类.微生物学;医嘱组类.微生物学试验;实验室医嘱组类.微生物学;微生物学医嘱组;微生物学医嘱组类 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 时刻;随机;随意;瞬间 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 痨 痨病 组 组合 组合医嘱 组合类 组套 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） 结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）与斑点（斑、点）计数组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） 结核病 肺结核 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74281-7
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/74281-7