75542-1

Hepatitis A virus RNA [Interpretation] in Plasma from Donor Qualitative by NAA with probe detection

Active

Term Description

Detects hepatitis A virus RNA (Genotypes 1-3) in human donor plasma, either from whole blood (recovered plasma) or collected by apheresis, prior to further manufacture. Plasma may be tested as individual specimens or in pools. Not intended for use on samples of cord blood or as an aid in diagnosis. This term was created for, but is not limited in use to, the cobas TaqScreen DPX test kit.
Source: Regenstrief LOINC

Part Descriptions

LP16708-7   Hepatitis A virus
Hepatitis A virus (Hep A or HAV) is an RNA virus that causes an acute infectious disease of the liver and is usually spread by the fecal-oral route. It is transmitted by ingestion of contaminated food or water or through direct contact with an infectious person. In developing countries, and in regions with poor hygiene standards, the incidence of infection with this virus is high. HAV infection produces a self-limited disease that usually does not result in chronic infection or chronic liver disease. Overall occurrence acute liver failure from Hepatitis A is rare (approx. 0.5%). The risk for symptomatic infection is directly related to age, with >80% of adults having symptoms compatible with acute viral hepatitis and the majority of children having either asymptomatic or unrecognized infection. Antibody produced in response to HAV infection persists for life and confers protection against reinfection. The disease can be prevented by vaccination, and hepatitis A vaccine has been proven effective in controlling outbreaks worldwide.

Although HAV is excreted in the feces towards the end of the incubation period, specific diagnosis is made by the detection of HAV-specific IgM antibodies in the blood. IgM antibody is only present in the blood following an acute hepatitis A infection. It is detectable from one to two weeks after the initial infection and persists for up to 14 weeks. The presence of IgG antibody in the blood means that the acute stage of the illness is past and the person is immune to further infection. IgG antibody to HAV is also found in the blood following vaccination and tests for immunity to the virus are based on the detection of this antibody. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Hepatitis A virus (Wikipedia)

LP16708-7   Hepatitis A virus
Hepatitis A virus (HAV) is a small, non-enveloped single-stranded RNA virus that belongs to the Picornaviridae family, genus Hepatovirus. HAV has six genotypes (I to VI) in which genotypes I to III are human isolates and IV to VI are only simian isolates. Genotypes I to III are subdivided into groups A and B. Genotype I is the most frequently reported. PMID: 15914081 The clinical manifestations of HAV infection can vary significantly and range from asymptomatic infection, usually seen in young children, to fulminant hepatitis, which can result in death. HAV has a global distribution, and transmission primarily occurs by the fecal-oral route. The risk of HAV transmission through blood products is very low, but there have been some reports of transmission through plasma products, mainly coagulation factors. PMID: 12186933 PMID: 1318940 Source: Regenstrief LOINC

Fully-Specified Name

Component

Hepatitis A virus RNA

Property

Imp

Time

Pt

System

Plas^Donor

Scale

Ord

Method

Probe.amp.tar

Additional Names

Long Common Name

Hepatitis A virus RNA [Interpretation] in Plasma from Donor Qualitative by NAA with probe detection

Short Name

HAV RNA Plas Donr NAA+probe-Imp

Display Name

HAV RNA NAA+probe Ql (P donor) [Interp]

Consumer Name Alpha Get Info

Hepatitis A virus (HAV), Donor Blood

Example Answer List: LL2888-7

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.50

Last Updated

Version 2.63

Order vs. Observation

Both

Member of these Panels

Language Variants Get Info

Related Names

• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Amplif
• Amplification
• Amplified
• DNA NUCLEIC ACID PROBE
• DNA probe
• Donr
• HAV
• Hep
• Hep A
• Hepatis
• Hepatit
• Hepatitis
• Hepatitis type A
• Hepatology
• ID
• Impression
• Impression/interpretation of study
• Impressions
• Infectious Disease
• InfectiousDisease
• Interp
• Interpretation
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Liver
• Microbiology
• NAA+probe
• NAAT
• NASBA
• Nucleic acid sequence based analysis
• Ordinal
• PCR
• Pl
• Plasma
• Plsm
• Point in time
• Polymerase chain reaction
• Probe amp
• Probe with ampification
• Probe with target amplification
• QBR
• QL
• Qual
• Qualitative
• Random
• Ribonucleic acid
• Screen
• SDA
• Strand Displacement Amplification
• TMA
• Transcription mediated amplification

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