78439-7
Phenytoin free and total trough panel - Serum or Plasma
Active
74983-8 Phenytoin Free [Mass/volume] in Serum or Plasma --trough
Part Descriptions
LP14731-1 Phenytoin.free
Phenytoin-free levels detect the level of non-protein-bound phenytoin in the blood. It is used to measure therapeutic and toxic levels of the drug.
Source: Regenstrief Institute
LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Trough levels for therapeutic drug monitoring
LP207910-3 free DRUG/TOX
The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug PMID: 6636249. For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Phenytoin.free^trough
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.48 (MIN)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 78439-7 | Phenytoin free and total trough panel - Serum or Plasma |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Φαινυτοΐνη.ελεύθερη^ελάχιστα επίπεδα: Synonyms: MCnc Φαινυτοΐνη Φαινυτοΐνη.ελεύθερη |
| es-MX | Spanish (Mexico) | Phenytoin.libre ^ comedero: |
| es-ES | Spanish (Spain) | Fenitoína libre^Valle monitorización terapéutica de fármacos: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Fenütoiin.vaba^baas: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-BE | French (Belgium) | Phénytoïne.libre^Creux: Synonyms: Minimum, nadir |
| fr-FR | French (France) | Diphénylhydantoïne libre taux résiduel: |
| fr-CA | French (Canada) | Phénytoïne.libre^Creux: |
| it-IT | Italian (Italy) | Fenitoina.libera^valore minimo: Synonyms: Concentrazione di Massa Fenitoina Libera Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM |
| nl-NL | Dutch (Netherlands) | fenytoïne.vrij^dalspiegel: |
| pt-BR | Portuguese (Brazil) | Fenitoina.livre^basal: |
| ru-RU | Russian (Russian Federation) | Фенитоин.свободный^остаточная концентрация: Synonyms: Количественный Массовая концентрация минимум концентрации Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Fenitoin.serb^en düşük: |
| zh-CN | Chinese (China) | 苯妥英.游离型^波谷: Synonyms: C15H12N2O2; |
Example Units
| Unit | Source |
|---|---|
| mg/L | Example UCUM Units |
74976-2 Phenytoin [Mass/volume] in Serum or Plasma --trough
Part Descriptions
LP14732-9 Phenytoin
An anticonvulsant that is used to treat a wide variety of seizure disorders. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its side effects and interactions with other drugs. [MeSH 2014: Phenytoin]
Source: National Library of Medicine, MeSH 2006
, MeSH: Phenytoin
LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, Trough levels for therapeutic drug monitoring
Fully-Specified Name
- Component
- Phenytoin^trough
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.48 (MIN)
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 78439-7 | Phenytoin free and total trough panel - Serum or Plasma |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG51075-6 | Phenytoin^trough| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| el-GR | Greek (Greece) | Φαινυτοΐνη^ελάχιστα επίπεδα: Synonyms: MCnc Φαινυτοΐνη |
| es-MX | Spanish (Mexico) | Fenitoína ^ comedero: |
| es-ES | Spanish (Spain) | Fenitoína^Valle monitorización terapéutica de fármacos: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Fenütoiin^baas: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-CA | French (Canada) | Phénytoïne^Creux: |
| fr-FR | French (France) | Diphénylhydantoïne taux résiduel: |
| fr-BE | French (Belgium) | Phénytoïne^Creux: Synonyms: Minimum, nadir |
| it-IT | Italian (Italy) | Fenitoina^valore minimo: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM |
| nl-NL | Dutch (Netherlands) | fenytoïne^dalspiegel: |
| pt-BR | Portuguese (Brazil) | Fenítoina^basal: |
| ru-RU | Russian (Russian Federation) | Фенитоин^остаточная концентрация: Synonyms: Количественный Массовая концентрация минимум концентрации Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Fenitoin^en düşük: |
| zh-CN | Chinese (China) | 苯妥英^波谷: Synonyms: C15H12N2O2; |
Example Units
| Unit | Source |
|---|---|
| mg/L | Example UCUM Units |