Version 2.78

Term Description

This term was created for the HepaScore liver fibrosis test, which is a marker of liver fibrosis in patients with hepatitis C infection. The score ranges from 0 to 1 and is calculated based on four lab tests (GGT, bilirubin, alpha-2-macroglobulin, and hyaluronic acid) plus the patient's age and gender. The HepaScore is reported with a central cut-off of 0.50, with a value ≥ 0.50 indicating that significant liver fibrosis is present (positive predictive value 88%) and a value < 0.50 indicating that advanced fibrosis is absent (negative predictive value 95%) for patients with hepatitis C infection. The HepaScore logistic regression model is as follows: y = exp[-4.185818 - (0.0249 x age) + (0.7464 x sex) + (1.0039 x α2-macroglobulin) + (0.0302 x hyaluronic acid) + (0.0691 x bilirubin) - (0.0012 x GGT)]
with age provided in years, male sex = 1, female sex = 0, α2-macroglobulin in g/L, hyaluronate in μg/L, bilirubin in μmol/L, and GGT in U/L. The score itself is calculated as y/(1 +y). PMID: 16055434
Source: Regenstrief LOINC

Part Description

LP193274-0   Liver fibrosis score
A liver fibrosis score is a noninvasive method used to determine the presence and degree of liver fibrosis in a patient based on a variety of different parameters (e.g., lab tests, age, and gender) depending on the method used. PMID: 21254180. Different methods used to calculate a patient's liver fibrosis score include the Enhanced Liver Fibrosis (ELF) test, nonalcoholic fatty liver disease (NAFLD) fibrosis score, HepaScore, FibroMeter, and FibroSURE. Source: Regenstrief LOINC

Fully-Specified Name

Component
Liver fibrosis score
Property
Score
Time
Pt
System
Ser/Plas
Scale
Qn
Method
Calculated.HepaScore

Additional Names

Long Common Name
Liver fibrosis score in Serum or Plasma Calculated by HepaScore
Short Name
Liver fibr score SerPl Calc HepaScore
Display Name
Liver fibrosis score Calculated by HepaScore [Score]
Consumer Name Alpha Get Info
Liver fibrosis score, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.54
Order vs. Observation
Both

Formula (Readable)

HepaScore = y/(1+y), where y = exp[-4.185818 - (0.0249 x age) + (0.7464 x sex) + (1.0039 x α2-macroglobulin) + (0.0302 x hyaluronic acid) + (0.0691 x bilirubin) - (0.0012 x GGT)]

Member of these Panels

LOINC Long Common Name
78698-8 Liver fibrosis score panel - Serum or Plasma Calculated by HepaScore

Member of these Groups Get Info

LOINC Group Group Name
LG19496-5 Liver fibrosis score|Score|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Puntuación fibrosis hepática:Puntuación:Punto temporal:Suero o Plasma:Qn:Calculado por HepaScore
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Puntuación de fibrosis hepática:Puntaje:Punto temporal:Suero o Plasma:Cuantitativo:Calculado por HepaScore
fr-FR French (France) Score de fibrose hépatique:Score:Ponctuel:Sérum/Plasma:Numérique:Calcul par Hepascore
it-IT Italian (Italy) Fibrosi epatica, punteggio:Punteggio:Pt:Siero/Plasma:Qn:Calcolato.HepaScore
Synonyms: Calcolato mediante HepaScore Chimica Plasma Punteggio di fibrosi Punto nel tempo (episodio) Siero Siero o Plasma
zh-CN Chinese (China) 肝纤维化评分:评分:时间点:血清/血浆:定量型:计算法.HepaScore
Synonyms: 分值;分数;得分 分值;得分;分数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 纤维化分值;纤维化得分;纤维变性评分（分值、得分、分数）;纤维化评分 肝 肝纤维化（肝脏纤维化、肝纤维症）评分（分值、得分、分数） 血清或血浆 计算;计算型方法

Example Units

Unit Source
{score} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=78894-3