Version 2.78

Status Information

Status
DEPRECATED
Reason
Ambiguous
Comment
This term is ambiguous because it does not distinguish between tropism based on intracellular, proviral DNA and extracellular viral RNA. It was created for a proviral DNA test but the System is not consistent with proviral DNA.
Map-To Long Common Name Mapping Guidance
80690-1 HIV 1 proviral DNA tropism [Identifier] in Blood mononuclear cells HIV 1 proviral DNA tropism [Identifier] in Mononuclear cells from whole blood
80688-5 HIV 1 RNA tropism [Identifier] in Plasma HIV 1 RNA tropism [Identifier] in Plasma

Part Description

LP65748-3   HIV 1 tropism
HIV enters cells by attaching first to the CD4 receptor and then to either the CCR5 or CXCR4 molecules, followed by fusion of the viral and cellular membranes. CCR5 coreceptor antagonists prevent HIV entry into target cells by binding to the CCR5 receptors. HIV tropism assays determine whether the HIV binds to CCR5, CXCR4 or both. An HIV tropism assay should be performed whenever the use of a CCR5 antagonist is being considered or a patient has virologic failure on a CCR5 antagonist.
During acute or recent infection, the vast majority of patients harbor a CCR5-binding virus (called R5 tropism), which suggests that the R5 variant is preferentially transmitted. Viruses in many untreated patients exhibit a shift in co-receptor tropism from CCR5 usage to either CXCR4 (X4 tropism) or both (D/M-tropic, which stands for dual or mixed), which is associated with a more rapid decline in CD4 T-cell counts. Patients who have been treated with anti-retroviral drugs and who have extensive drug resistance are more likely to harbor X4- or D/M-tropic variants than untreated patients with comparable CD4 counts. The prevalence of X4- or D/M-tropic variants increases to more than 50% in treated patients who have CD4 counts <100 cells/mm3. [https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf] Source: Regenstrief LOINC, NIH adult and adolescent HIV guidelines

Fully-Specified Name

Component
HIV 1 tropism
Property
Prid
Time
Pt
System
Bld
Scale
Nom
Method

Additional Names

Short Name
Deprecated HIV1 tropism Bld
Display Name
HIV 1 tropism Nom (Bld)
Consumer Name Alpha Get Info
HIV 1 tropism, Blood

Example Answer List: LL2265-8

Source: Regenstrief LOINC
Answer Code Score Answer ID
R5

Viruses or virus populations that use only the CCR5 chemokine co-receptor to infect CD4+ cells.

 LA19204-9
X4

Viruses or virus populations that use only the CXCR4 chemokine co-receptor to infect CD4+ cells.

 LA19205-6
D/M

Dual (D)-tropic: Viruses or virus populations that can use either the CCR5 or CXCR4 co-receptors to infect CD4+ cells. Mixed (M)-tropic: Virus populations that may contain various combinations of R5 virus, X4 virus, and/or dual-tropic viruses

 LA19206-4

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.56
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Tropismo de VIH-1:Presencia o identidad:Punto temporal:Sangre:Nom:
es-MX Spanish (Mexico) Tropismo del VIH 1:Presencia o identidad:Punto temporal:Sangre:Nominal:
fr-CA French (Canada) VIH 1 tropisme:Présence ou identité:Temps ponctuel:Sang:Nominal:
fr-BE French (Belgium) HIV 1 tropisme:Présence ou identité:Temps ponctuel:Sang:Nominal:
Synonyms: HIV HIV 1 HIV 1. Tropisme
it-IT Italian (Italy) HIV 1, tropismo:Prid:Pt:Sangue:Nom:
Synonyms: Microbiologia Presenza o Identità Punto nel tempo (episodio) Sangue Tropismo dell''HIV 1
nl-NL Dutch (Netherlands) HIV 1 tropisme:identificator:moment:bloed:nominaal:
pl-PL Polish (Poland) HIV 1 tropizm:wykrycie lub identyfikacja:punkt w czasie:krew:cecha:
Synonyms: Ludzki wirus niedoboru odporności typu 1 Tropizm ludzkiego wirusa niedoboru odporności typu 1
ru-RU Russian (Russian Federation) HIV 1 тропизм:ПрИд:ТчкВрм:Кр:Ном:
Synonyms: ВИЧ ВИЧ 1 Кровь Номинальный;Именной Присутствие или Идентификация Точка во времени;Момент
tr-TR Turkish (Turkey) HIV 1 tropism:MevcKimlik:Zmlı:Kan:Snf:
zh-CN Chinese (China) HIV 1 型 嗜性:存在与否或特征标识:时间点:全血:名义型:
Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）嗜性（向性、趋性、趋向性）;HIV 1 亲嗜性;HIV 1 向性;HIV 1 细胞嗜性;HIV 1 趋向性;HIV 1 趋性;HIV1 嗜性;HTLV 3 嗜性;HTLV III 嗜性;人类免疫缺陷病毒 1 型 嗜性;人类免疫缺陷病毒 I 型 嗜性 HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 存在;存在与否;特征标识;身份;身份标识 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79155-8