Version 2.80

Term Description

Examples of lower respiratory tract specimens include broncho-alveolar lavage, bronchial wash, tracheal aspirate, sputum, or lung tissue.

Part Descriptions

LP14255-1   Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html] Source: Regenstrief LOINC

LP36602-8   Shell vial culture
Virus culture is often more sensitive than trying to detect viruses directly in clinical samples. Shell vial culture is a modification of the conventional cell culture technique for rapid detection of viruses in vitro. The technique involves inoculation of the clinical specimen on to cell monolayer grown on a cover slip in a shell vial culture tube, followed by low speed centrifugation and incubation. This system works on the principle that the low speed centrifugation enhances viral infectivity to the susceptible cells. It is thought that the minor trauma to the cell surface produced as a result of low speed centrifugation mechanical force enhances the viral entry in to the cells, which in turn reduces the total time taken for the virus to produce infection of cells. Virus may be detected by direct fluorescent antibody (DFA) or indirect fluorescent antibody (IFA) staining within hours or days of inoculation. Source: Regenstrief LOINC

Fully-Specified Name

Component
Cytomegalovirus
Property
PrThr
Time
Pt
System
Respiratory system specimen.lower
Scale
Ord
Method
Shell vial culture

Additional Names

Long Common Name
Cytomegalovirus [Presence] in Lower respiratory specimen by Shell vial culture
Short Name
CMV Lower resp Ql Shell Vial Cult
Display Name
CMV Shell vial culture Ql (Lower resp)
Consumer Name Alpha Get Info
Cytomegalovirus (CMV) culture, Lower respiratory

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.77 (MAJ)
Change Reason
Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG34000-6 Cytomegalovirus|PrThr|Sys:ANYResp

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Cytomegalie-Virus:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt.unterer:Ordinal:Shell-Vial-Kultur
Synonyms: CMV
el-GR Greek (Greece) Κυτταρομεγαλοϊός:PrThr:Pt:Δείγμα αναπνευστικού συστήματος.κατώτερο:Ord:Ταχεία κυτταροκαλλιέργεια σε φιάλη
Synonyms: PrThr Κυτταρομεγαλοϊός
es-MX Spanish (Mexico) Citomegalovirus:Presencia o umbral:Punto temporal:Muestra de vías respiratorias inferiores:Ordinal:Cultivo de viales de concha
es-ES Spanish (Spain) Citomegalovirus:PrThr:Punto temporal:Muestra de vías respiratorias inferiores:Ord:Cultivos en "shell vial"
Synonyms: Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
fr-FR French (France) Cytomégalovirus:Présence/Seuil:Ponctuel:Échantillon du système respiratoire inférieur:Qualitatif:Culture fiole de coquille
it-IT Italian (Italy) Citomegalovirus:PrThr:Pt:Campione da Sistema Respiratorio.inferiore:Ord:Shell vial, coltura
Synonyms: Campione da Apparato Respiratorio Campione da apparato respiratorio inferiore Coltura Shell vial Microbiologia Presenza o Soglia Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) Cytomegalovirus:aanwezigheid:moment:onderste luchtwegen:ordinaal:Shell vial'-kweek
Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior systema respiratorium; ademhalingsstelsel
zh-CN Chinese (China) 巨细胞病毒:存在情况或阈值:时间点:呼吸系统标本.下:序数型:细胞培养瓶培养法
Synonyms: CMV;涎腺病毒;细胞巨化病毒;细胞肥大病毒 SVC 法;SVCC 法;小孔细胞培养法;带盖小瓶培养法;平底小瓶培养法;平底小管培养法;快速组织培养方法;细胞培养瓶培养（Shell Vial Culture，SVC）;细胞瓶培养法 下 下的 下部 低级 低级的 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 受检物 呼吸系统（呼吸道）标本.下;下呼吸系统标本;下呼吸道标本 呼吸道标本（样品、样本）;呼吸系统标本（样品、样本） 培养方法 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 样品 样本 试样 较低 较低的

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81328-7