Version 2.78

Part Descriptions

LP36464-3   Microsatellite instability
The appearance of abnormally long or short microsatellites in an individual's DNA is referred to as microsatellite instability. Microsatellite instability (MSI) is a condition manifested by damaged DNA due to defects in the normal DNA repair process. Sections of DNA called microsatellites, which consist of a sequence of repeating units of 1-6 base pairs in length, become unstable and can shorten or lengthen. Microsatellites are also known as simple sequence repeats (SSRs). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP36464-3   Microsatellite instability
Microsatellite instability (MSI) is a change in the number of repeats of a specific DNA marker in cancer cells compared to the number of repeats present in non-cancerous cells of the same patient. Different tumor types are associated with different MSI markers, and both the presence of MSI in specific markers as well as the the number of distinct markers demonstrating MSI is important. Tumor cells are classified as being stable, having high instability (MSI-H), or having low instability (MSI-L) based on the number of markers demonstrating MSI. MSI analysis may help guide therapy and be a prognostic indicator. Specific MSI markers include BAT25, BAT26, D2S123, D5S346, D17S2720, NR21, NR24 and MONO27. MSI has been most studied in colorectal cancer, and colorectal tumors that are MSI-H are more likely to be carcinomas than adenomas. MSI has also been studied in other types of cancer, including gastric cancer, breast cancer, lung cancer and Wilms tumor. Source: Regenstrief LOINC

Fully-Specified Name

Component
Microsatellite instability
Property
Imp
Time
Pt
System
Cancer specimen
Scale
Ord
Method

Additional Names

Short Name
MSI Ca spec-Imp
Display Name
Microsatellite instability Ql (Cancer specimen) [Interp]
Consumer Name Alpha Get Info
Microsatellite instability, Cancer specimen

Example Answer List: LL3994-2

Source: ARUP Laboratories
Answer Code Score Answer ID
Stable LA14122-8
MSI-L

Microsatellite instability - low

 LA26202-4
MSI-H

Microsatellite instability - high

 LA26203-2
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.61
Change Reason
Updated System from "Tiss" to "Cancer.XXX" because MSI testing is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85905-8 Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols
81711-4 Microsatellite instability marker panel - Cancer specimen

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Inestabilidad microsatelite:Impresión/interpretación del estudio:Punto temporal:Muestra de cancer:Ord:
es-MX Spanish (Mexico) Inestabilidad de microsatélites:Impresión / interpretación del estudio:Punto temporal:Espécimen de cáncer:Ordinal:
it-IT Italian (Italy) Microsatelliti, instabilità:Imp:Pt:Campione tumore:Ord:
Synonyms: Campione di tumore Impressione/interpretazione di studio Instabilità dei microsatelliti Neoplasia maligna Patologia Punto nel tempo (episodio)
zh-CN Chinese (China) 微卫星不稳定性:印象:时间点:癌标本:序数型:
Synonyms: MSI 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 受检物 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 试样

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81695-9