Version 2.80

Term Description

The DNA amplification target is the 283-bp plasminogen-binding protein gene (oppA1), which is present at a frequency of one copy per organism in all four pathogenic species of the Borrelia burgdorferi sensu lato genogroup (Borrelia burgdorferi sensu stricto, Borrelia afzelii, Borrelia garinii, and Borrelia mayonii). Melting curve analysis is used to differentiate B. afzelii and B. garinii from the other two species but cannot differentiate between B. afzelii and B. garinii. Potential specimens include CSF, tissue, and synovial fluid.

Part Descriptions

LP220480-0   Borrelia garinii+afzelii oppA1 gene
Lyme disease is a multisystem, multistage infection caused by three species of tick-borne spirochetes in the Borrelia burgdorferi sensu lato genogroup. These spirochetes include B. burgdorferi sensu stricto (North America and Western Europe), B. afzelii (Central and Western Europe and Russia), and B. garinii (Europe, Russia, and northern Asia). Endemic areas for Lyme disease in the United States correspond with the distribution of two tick species, Ixodes dammini (Northeastern and Upper Midwestern US) and Ixodes pacificus (West Coast US). In Europe, Ixodes ricinus transmits the spirochete. Human Lyme borreliosis, the most prevalent arthropod-borne infection in temperate climate zones around the world, is an inflammatory disorder characterized by the skin lesion erythema migrans and the potential development of neurologic, cardiac, and joint abnormalities. B. garinii, the most neurotropic of these three genospecies, causes most neurologic Lyme disease in Europe, including cases of meningopolyneuritis and, rarely, encephalomyelitis. Although probably all three genospecies can cause all major manifestations, it appears that infection with different B. burgdorferi sensu lato genospecies results in distinct presentations of Lyme borreliosis. In Europe, B. afzelii is mostly associated with skin manifestations, such as erythema migrans, and acrodermatitis chronica atrophicans, whereas B. garinii is the main cause of Lyme neuroborreliosis. Patients with B. garinii isolated from CSF samples have a distinct clinical presentation, compared with that of patients with B. afzelii infection. PMID: 16912943 PMID: 12454161 Source: Regenstrief LOINC

LP220480-0   Borrelia garinii+afzelii oppA1 gene
The oppA1 gene is a member of a family of three genes; oppA-1, oppA-2, and oppA-3, that encode predicted peptide-binding proteins. Peptide-binding protein dependent transport systems are recognized to play important roles in microbial cell signaling and virulence. PMID: 9712756 Source: Regenstrief LOINC

Fully-Specified Name

Component
Borrelia garinii+afzelii oppA1 gene
Property
PrThr
Time
Pt
System
XXX
Scale
Ord
Method
Non-probe.amp.tar

Additional Names

Long Common Name
Borrelia garinii+afzelii oppA1 gene [Presence] in Specimen by NAA with non-probe detection
Short Name
B gar+afz oppA1 Spec Ql NAA+non-probe
Display Name
B. garinii+afzelii oppA1 gene NAA+non-probe Ql (Specimen)
Consumer Name Alpha Get Info
Borrelia garinii+afzelii oppA1 gene, Specimen

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.69 (MIN)
Change Reason
Release 2.68: COMPONENT: Removed parentheses from Component for consistency and accuracy.; Previous Releases:
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Γονίδιο βακτηρίων Borrelia garinii+afzelii oppA1:PrThr:Pt:XXX:Ord:Χωρίς ανιχνευτή.ενίσχυση.στόχου
Synonyms: PrThr Βακτήριο Borrelia garinii Γονίδιο Γονίδιο βακτηρίων Borrelia garinii+afzelii oppA1
es-ES Spanish (Spain) Gen oppA1 de Borrelia garinii+afzelii:PrThr:Punto temporal:XXX:Ord:Amplificación del objetivo no basado en sonda
es-MX Spanish (Mexico) Borrelia garinii + gen oppA1 de afzelii:Presencia o umbral:Punto temporal:XXX:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
fr-FR French (France) Borrelia garinii+afzelii gène oppA1:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Non-PCR amplification de cible
it-IT Italian (Italy) Borrelia garinii+afzelii (oppA1), gene:PrThr:Pt:XXX:Ord:Non-sonda.amp.tar
Synonyms: Amplificazione target non basata su sonda Gene Borrelia garinii+afzelii (oppA1) Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
zh-CN Chinese (China) 加里疏螺旋体+阿夫塞疏螺旋体 oppA1 基因:存在情况或阈值:时间点:XXX:序数型:非探针法.基因扩增.靶向
Synonyms: 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 借助靶向扩增的非探针方法;借助靶向扩增的非探针法;非探针法.扩增.靶向 加里疏螺旋体（加里螺旋体菌、伽里疏螺旋体、加林螺旋体菌、伽里尼疏螺旋体、伽氏疏螺旋体、Garinii 疏螺旋体）+阿夫塞疏螺旋体（Afzelii 疏螺旋体、Afzelii 螺旋体、阿氏疏螺旋体、Afzelii 包柔氏螺旋体） oppA1 基因;中国莱姆病螺旋体;莱姆病;莱姆病螺旋体 加里螺旋体菌;伽里疏螺旋体;加林螺旋体菌;伽里尼疏螺旋体;伽氏疏螺旋体;Garinii 疏螺旋体;中国莱姆病螺旋体;莱姆病;莱姆病螺旋体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82472-2