Version 2.78

Term Description

This assay detects both the 65kD and 67kD isoforms of glutamate decarboxylase but does not distinguish between the two.
Source: Regenstrief LOINC

Part Description

LP230194-5   Glutamate decarboxylase
Paraneoplastic neurological syndrome (PNS) is an autoimmune disorder that is manifested by progressive central, peripheral and/or autonomic nervous system symptoms. The neurological symptoms include encephalitis, autonomic failure, peripheral neuropathy, cerebellar ataxia, visual complaints and more. The antibodies that attack the neural tissue develop in response to tumor cells. The neoplasm may or may not be detectable using conventional imaging modalities. Since PNS can be associated with multiple antibodies testing usually includes a panel of PNS antibodies. In addition, the different PNS antibodies are associated with certain cancers so the antibody pattern can assist in identifying the specific tumor if it was previously undiagnosed. PMID: 22412264Glutamate decarboxylase (GAD) is an enzyme that leads to the creation of the major neurotransmitter gamma-aminobutyrate (GABA). The initial discovery of GAD antibodies was found in a patient with stiff-person syndrome. Later, GAD antibodies were identified in many patients with type 1 diabetes. Patients with chronic cerebellar ataxia, drug-resistant epilepsy and myoclonus have also been found to have GAD antibodies. PMID: 12536283 GAD has two isoforms, GAD65 and GAD67, which are highly homologous but found in distinct subsets of patients. GAD65 antibodies are specific to patients with insulin-dependent diabetes. PMID: 7532143 GAD67 is important to the maturation of perisomatic innervation.( http://www.sciencedirect.com/science/article/pii/S0896627307003728) The presence of GAD antibodies in a patient recently diagnosed with diabetes indicates a high risk of requiring insulin within three years. PMID: 11114103 Source: Regenstrief LOINC

Fully-Specified Name

Component
Glutamate decarboxylase Ab
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
IF

Additional Names

Short Name
GAD Ab SerPl Ql IF
Display Name
Glutamate decarboxylase Ab IF Ql
Consumer Name Alpha Get Info
Glutamate decarboxylase antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Glutamato descarboxilasa Anticuerpos:PrThr:Punto temporal:Suero o Plasma:Ord:Inmunofluorescencia (IF)
es-MX Spanish (Mexico) Glutamato descarboxilasa Ab:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Inmunofluorescencia (IF)
fr-FR French (France) Glutamate décarboxylase anticorps:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Immunofluorescence
it-IT Italian (Italy) Glutammato decarbossilasi Ab:PrThr:Pt:Siero/Plasma:Ord:IF
Synonyms: anticorpo Chimica Immunofluorescenza (IF) Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) glutamaatdecarboxylase As:aanwezigheid:moment:serum of plasma:ordinaal:immunofluorescentie
Synonyms: antistof; antilichaam IF
zh-CN Chinese (China) 谷氨酸脱羧酶 抗体:存在情况或阈值:时间点:血清/血浆:序数型:免疫荧光法
Synonyms: Ab;自身抗体 Glu IFA法;IF法;抗补体免疫荧光法;时间分辨荧光法;荧光原位杂交技术;荧光原位杂交法;荧光抗体 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 血清或血浆 麸胺酸去羧酶;麸胺酸去羧基酶;麸氨酸去羧基酶;GAD

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