Version 2.78

Part Description

LP247956-8   Mitotic rate
The degree of mitotic activity in breast carcinoma is one component of the Nottingham histologic grade (NHG) [LOINC: 44648-4], which is a prognostic indicator for patients with breast carcinoma. The two other components of the NHG are tubule formation [LOINC: 85321-8] and nuclear pleomorphism [LOINC: 44645-0]. Mitotic activity is assessed as the number of mitoses per 10 high power fields (HPF), with increasing mitotic activity being an indicator of more aggressive cancer. The specific scores assigned to the number of mitoses depends on the size of the HPF. For example, for a HPF size of 0.274 mm^2, less than 10 mitoses per 10 HPF gets a score of 1, 10-19 gets a score of 2, and greater than or equal to 20 gets a score of 3. When larger or smaller HPFs are used, the cutoffs for the number of mitoses corresponding to a specific score are adjusted according to published guidelines. PMID: 11865000 Source: Regenstrief LOINC

Fully-Specified Name

Component
Mitotic rate
Property
Score
Time
Pt
System
Breast cancer specimen
Scale
SemiQn
Method
Nottingham

Additional Names

Short Name
Mitotic rate Score Br ca spec Nottingham
Display Name
Mitotic rate Nottingham (Breast cancer specimen) [Score]
Consumer Name Alpha Get Info
Mitotic rate, Breast cancer specimen

Normative Answer List: LL4383-7

Source: College of American Pathologists
Answer Code Score Answer ID
Score 1 1 LA27225-4
Score 2 2 LA27226-2
Score 3 3 LA27227-0
No residual invasive carcinoma after presurgical (neoadjuvant) therapy 0 LA27220-5
Score cannot be determined 0 LA27221-3

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.75
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85904-1 Cancer pathology panel - Breast cancer specimen by CAP cancer protocols

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) indice mitotico:Puntuación:Punto temporal:Muestra de cancer de mama:Semicuantitativo:Nottingham
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Tasa mitótica:Puntaje:Punto temporal:Muestra de cáncer de mama:Ordinal:Nottingham
it-IT Italian (Italy) Tasso mitotico:Punteggio:Pt:Tumore della mammella, campione:SemiQn:Nottingham
Synonyms: Campione di tumore Campione di tumore della mammella Neoplasia maligna Patologia Petto Punto nel tempo (episodio)
zh-CN Chinese (China) 有丝分裂率:评分:时间点:乳腺癌标本:半定量型:诺丁汉法
Synonyms: Nottingham 法 乳房 乳腺癌（乳癌）标本（样本、样品、试样） 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分值;得分;分数 受检物 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 试样 速度

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85300-2