Version 2.78

Part Description

LP247955-0   Glandular differentiation
The degree of glandular differentiation or tubule formation in breast carcinoma is one component of the Nottingham histologic grade (NHG) [LOINC: 44648-4], which is a prognostic indicator for patients with breast carcinoma. The two other components of the NHG are nuclear pleomorphism [LOINC: 44645-0] and mitotic activity [LOINC: 85300-2]. Less aggressive cancers have more tubule formation, with scores assigned as follows:
1 = greater than 75% of the tumor area contains tubular or glandular structures
2 = 10 to 75% of the tumor area contains tubular structures
3 = less than 10% of the tumor area contains tubular structures
PMID: 11865000 Source: Regenstrief LOINC

Fully-Specified Name

Component
Glandular differentiation
Property
Score
Time
Pt
System
Breast cancer specimen
Scale
SemiQn
Method
Nottingham

Additional Names

Short Name
Gland diff Score Br ca spec Nottingham
Display Name
Glandular differentiation Nottingham (Breast cancer specimen) [Score]
Consumer Name Alpha Get Info
Glandular differentiation, Breast cancer specimen

Normative Answer List: LL4380-3

Source: College of American Pathologists
Answer Code Score Answer ID
Score 1: >75% of tumor area forming glandular/tubular structures 1 LA27216-3
Score 2: 10% to 75% of tumor area forming glandular/tubular structures 2 LA27217-1
Score 3: <10% of tumor area forming glandular/tubular structures 3 LA27218-9
Only microinvasion present (not graded) 0 LA27219-7
No residual invasive carcinoma after presurgical (neoadjuvant) therapy 0 LA27220-5
Score cannot be determined 0 LA27221-3

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.61
Last Updated
Version 2.75
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85904-1 Cancer pathology panel - Breast cancer specimen by CAP cancer protocols

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) difeencacion glandular:Puntuación:Punto temporal:Muestra de cancer de mama:Semicuantitativo:Nottingham
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Diferenciación glandular:Puntaje:Punto temporal:Muestra de cáncer de mama:Ordinal:Nottingham
it-IT Italian (Italy) Differenziazione ghiandolare:Punteggio:Pt:Tumore della mammella, campione:SemiQn:Nottingham
Synonyms: Campione di tumore Campione di tumore della mammella Neoplasia maligna Patologia Petto Punto nel tempo (episodio)
zh-CN Chinese (China) 腺体分化:评分:时间点:乳腺癌标本:半定量型:诺丁汉法
Synonyms: Nottingham 法 乳房 乳腺癌（乳癌）标本（样本、样品、试样） 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分值;得分;分数 受检物 时刻;随机;随意;瞬间 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 试样

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=85321-8