86202-9
Porcine epidemic diarrhea virus [Presence] in Tissue by Immune stain
Active
Term Description
Sample types for this test include formalin-fixed, paraffin-embedded tissue samples, frozen samples, or cell smears/cultures.
Source: Regenstrief LOINC
Part Description
LP182479-8 Porcine epidemic diarrhea virus
Porcine Epidemic Diarrhea Virus (PEDv) is a large-enveloped RNA virus, which is a member of the genus Alphacoronavirus within the Coronaviridae family. The complete PEDv genome consists of 5 gene segments: open reading frame 1 (ORF1), spike (S), envelope (E), membrane (M), and nucleocapsid (N). It is encapsulated by a single N protein. The S protein contributes to the stimulation of neutralizing antibodies in the infected host. Its association to adapted growth in vitro and attenuation in vivo lends itself to use for genetic comparison among PEDV isolates and effective vaccines. The M protein is required for assembly and can also induce the production of virus-neutralizing antibodies. The E protein contributes to coronavirus budding. The N protein has functions associated with viral replication and pathogenesis.
PEDv causes viral enteritis, which leads to the destruction of villus enterocytes in pigs of all ages. It is spread by the ingestion of feces from infected pigs, resulting in vomiting, watery diarrhea, dehydration, and high mortality, especially in nursery piglets. Disease caused by PEDv is clinically similar to that caused by Transmissible gastroenteritis coronavirus (TGEV) PMID: 26689811
At least two PEDv strains have been identified in the USA: the US PEDv prototype and S INDEL variant. The INDEL variant PEDv strain has insertions and deletions (INDELs) in the spike (S) gene. PMID: 25279722 The INDEL strain is related to milder clinical signs than prototype strains. PMID: 24750580 PMID: 26748596 The genomic differences in the S gene between the US PEDv prototype and INDEL variant may be responsible for the virulence differences. Potential targets when testing for PEDv RNA include the nucleocapsid protein (N) gene and the ~2500 bp fragment of the S-gene.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Porcine epidemic diarrhea virus
- Property
- PrThr
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- Immune stain
Additional Names
- Short Name
- PEDv Tiss Ql ImStn
- Display Name
- Porcine epidemic diarrhea virus Immune stain Ql (Tiss)
- Consumer Name Alpha Get Info
- Porcine Epidemic Diarrhea virus, Tissue
Example Answer List: LL360-9
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.61
- Last Updated
- Version 2.63
- Change Reason
- Updated System from "Tissue" to "Tiss" to be consistent with other laboratory tissue terms.
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Virus de la diarrea epidémica porcina: |
| es-MX | Spanish (Mexico) | Virus de la diarrea epidémica porcina: |
| it-IT | Italian (Italy) | Virus della diarrea epidemica suina: Synonyms: Microbiologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | 'porcine' epizoötisch diarreevirus: Synonyms: epizoötisch diarreevirus van varken porcine |
| pl-PL | Polish (Poland) | Wirus epidemicznej biegunki świń: Synonyms: barwnik immunologiczny |
| ru-RU | Russian (Russian Federation) | Свиная эпидемическая диаррея вирус: Synonyms: Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | Porsin epidemik diyare virüsü: Synonyms: Mevcut |
| zh-CN | Chinese (China) | 猪流行性腹泻病毒: Synonyms: 下痢; |
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