87556-7
Thyroglobulin and thyroperoxidase Ab panel - Serum or Plasma
Active
8098-6 Thyroglobulin Ab [Units/volume] in Serum or Plasma
Part Descriptions
LP14697-4 Thyroglobulin
Thyroglobulin (Tg) is a protein produced by and used entirely within the thyroid gland. Thyroglobulin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is stored in the thyroid in follicle cysts surrounded by colloid cells. Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Thyroxine is produced by linking two moieties of DIT. Combining one particle of MIT and one particle of DIT produces triiodothyronine. Proteases in lysosomes digest iodinated thyroglobulin, releasing T3 and T4. Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves Disease.
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Source: Wikipedia
, Thyroglobulin (Wikipedia)
LP14697-4 Thyroglobulin
Thyroglobulin (Tg) is a glycoprotein homodimer produced by the thyroid gland. It is important in the synthesis of thyroxine and triiodothyronine, and is where the inactive forms of thyroid hormone and iodine are stored. Mutations in the Tg gene cause thyroid dyshormonogenesis resulting in goiter, and can be associated with moderate to severe congenital hypothyroidism. Polymorphisms in the Tg gene are associated with susceptibility to autoimmune thyroid diseases such as Graves disease or Hashimoto thyroiditis. [NCBI Gene ID:7038] Tg is an established tumor marker used in the diagnosis of differentiated thyroid carcinoma. PMID: 9543128
Source: Regenstrief LOINC
LP39996-1 Thyroglobulin Ab
Circulating immunoglobulins directed against thyroglobulin are commonly present in patients with autoimmune (Hashimoto) thyroiditis and, to a lesser extent, Graves disease. Thyroglobulin is a 660-kd protein precursor of thyroid hormones. Thyroglobulin antibodies are present in the sera of approximately 70% of patients with autoimmune thyroiditis. The principal use of the test is to confirm that a patient's diffuse goiter and/or hypothyroidism is due to autoimmune thyroiditis. The test may also help distinguish Graves disease from toxic nodular goiter. Although thyroglobulin antibodies are present less often than thyroid microsomal antibodies (eg, thyroid peroxidase antibodies, anti-TPO) in patients with autoimmune thyroid diseases, screening fro both immunoglobulins increases diagnostic sensitivity. Thyroglobulin antibodies may be detected in individuals without clinically significant thyroid disease. They do not define the patient's thyroid functional status.
Source: Quest Diagnostics Inc.
, Thyroglobulin antibodies
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. | Thyroid Antibodies |
Fully-Specified Name
- Component
- Thyroglobulin Ab
- Property
- ACnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 1.0h(2)
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 619
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 57780-9 | Thyroglobulin and Thyroglobulin Ab panel - Serum or Plasma |
| 87556-7 | Thyroglobulin and thyroperoxidase Ab panel - Serum or Plasma |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG21864-0 | Thyroglobulin Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: Thyreoglobulin-AK |
| de-DE | German (Germany) | Thyreoglobulin Ak: Synonyms: hTG |
| el-GR | Greek (Greece) | Θυρεοσφαιρίνη Αντίσωμα: Synonyms: ACnc Θυρεοσφαιρίνη |
| es-AR | Spanish (Argentina) | [anticuerpo anti - ] tiroglobulina [Ac]: |
| es-MX | Spanish (Mexico) | Tiroglobulina Ab: |
| es-ES | Spanish (Spain) | Tiroglobulina Anticuerpos: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Türeoglobuliin antikehad: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-FR | French (France) | Thyroglobuline anticorps: |
| fr-CA | French (Canada) | Thyroglobuline, Ac: |
| fr-BE | French (Belgium) | Thyroglobuline Ac: Synonyms: Anticorps hTG |
| it-IT | Italian (Italy) | Tireoglobulina Ab: Synonyms: anticorpo Concentrazione Arbitraria Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant |
| ko-KR | Korean (Korea, Republic Of) | 갑상샘글로불린 항체: |
| nl-NL | Dutch (Netherlands) | thyreoglobuline As: Synonyms: antistof; |
| pt-BR | Portuguese (Brazil) | Tireoglobulina Ac: Synonyms: AntiTiroglob; |
| ru-RU | Russian (Russian Federation) | Тиреоглобулин Ат: Synonyms: Антитело Количественный Плазма Произвольная концентрация Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Tiroglobulin Ab: |
| uk-UA | Ukrainian (Ukraine) | Тиреоглобулін Антитіла: Synonyms: ABS; |
| zh-CN | Chinese (China) | 甲状腺球蛋白 抗体: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| [IU]/mL | Example UCUM Units |
| IU/mL | eCHN |
8099-4 Thyroperoxidase Ab [Units/volume] in Serum or Plasma
Part Descriptions
LP17727-6 Thyroperoxidase
Thyroid peroxidase is an enzyime that is required in order for iodine to be added to the protein thyroglobulin, a precursor to the generation of thyroid hormones which are important in the physical growth, brain development and metabolism of the body. If thyroid peroxidase is not produced or blocked by antibodies, hypothyroidism occurs. Symptoms of hypothyroidism include fatigue, weight gain, muscle weakness, increased cholesterol levels, depression and impaired memory. [MedlinePlus Gene:TPO]
Source: Regenstrief LOINC
LP40001-7 Thyroperoxidase Ab
Thyroperoxidase antibodies aid in the detection of autoimmune and Hashimoto's thyroiditis. Antibodies against the thyroid are seldom seen in serum of normal individuals but 5-10% of patients may have low levels of antibodies with no signs of disease. These antibodies maybe associated with other autoimmune disorders (cross-reactive antibodies).
Source: Regenstrief Institute
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Lab Tests Online®Copyright Copyright © 2021 Lab Tests Online. All rights reserved. | Thyroid Antibodies |
Fully-Specified Name
- Component
- Thyroperoxidase Ab
- Property
- ACnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 1.0h(2)
- Last Updated
- Version 2.73 (MIN)
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 551
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 87556-7 | Thyroglobulin and thyroperoxidase Ab panel - Serum or Plasma |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG359-6 | Thyroperoxidase Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Thyreoperoxidase Ak: Synonyms: TPO |
| de-AT | German (Austria) | Synonyms: TPO-AK |
| el-GR | Greek (Greece) | Θυρεοϋπεροξειδάση Αντίσωμα: Synonyms: ACnc Θυρεοϋπεροξειδάση |
| es-MX | Spanish (Mexico) | Tiroperoxidasa Ab: |
| es-ES | Spanish (Spain) | Tiroperoxidasa Anticuerpos: Synonyms: Cuantitativo |
| es-AR | Spanish (Argentina) | [anticuerpo anti - ] tiroperoxidasa [Ac]: |
| et-EE | Estonian (Estonia) | Türeoidperoksüdaasivastased antikehad: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-BE | French (Belgium) | Thyroperoxidase Ac: Synonyms: Anticorps TPO |
| fr-FR | French (France) | Thyroperoxidase anticorps: |
| fr-CA | French (Canada) | Thyroperoxidase, Ac: |
| it-IT | Italian (Italy) | Tireoperossidasi Ab: Synonyms: anticorpo Concentrazione Arbitraria Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant TPO |
| ko-KR | Korean (Korea, Republic Of) | Thyroperoxidase Antibody: |
| nl-NL | Dutch (Netherlands) | thyreoperoxidase As: Synonyms: antistof; |
| pt-BR | Portuguese (Brazil) | Tiroperoxidase Ac: Synonyms: Thyroid Microsomal; |
| ru-RU | Russian (Russian Federation) | Тиреопероксидаза Ат: Synonyms: Антитело Количественный Плазма Произвольная концентрация Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Tiroperoksidaz Ab: |
| uk-UA | Ukrainian (Ukraine) | Тиреопероксидаза Антитіла: Synonyms: ABS; |
| zh-CN | Chinese (China) | 甲状腺过氧化物酶 抗体: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| [IU]/mL | Example UCUM Units |
| IU/mL | eCHN |