88624-2
Cytomegalovirus [Presence] in Amniotic fluid by Shell vial culture
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Part Descriptions
LP14255-1 Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html]
Source: Regenstrief LOINC
LP36602-8 Shell vial culture
Virus culture is often more sensitive than trying to detect viruses directly in clinical samples. Shell vial culture is a modification of the conventional cell culture technique for rapid detection of viruses in vitro. The technique involves inoculation of the clinical specimen on to cell monolayer grown on a cover slip in a shell vial culture tube, followed by low speed centrifugation and incubation. This system works on the principle that the low speed centrifugation enhances viral infectivity to the susceptible cells. It is thought that the minor trauma to the cell surface produced as a result of low speed centrifugation mechanical force enhances the viral entry in to the cells, which in turn reduces the total time taken for the virus to produce infection of cells. Virus may be detected by direct fluorescent antibody (DFA) or indirect fluorescent antibody (IFA) staining within hours or days of inoculation.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Cytomegalovirus
- Property
- PrThr
- Time
- Pt
- System
- Amnio fld
- Scale
- Ord
- Method
- Shell vial culture
Additional Names
- Short Name
- CMV Amn Ql Shell Vial Cult
- Display Name
- CMV Shell vial culture Ql (Amn fld)
- Consumer Name Alpha Get Info
- Cytomegalovirus (CMV) culture, Amniotic fluid
Example Answer List: LL1937-3
Source: 3M Health Information Systems| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PresentCopyright http://snomed.info/sct ID:52101004 Present (qualifier value) | LA9633-4 | ||
| AbsentCopyright http://snomed.info/sct ID:2667000 Absent (qualifier value) | LA9634-2 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.64
- Last Updated
- Version 2.64
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Cytomegalie-Virus: Synonyms: CMV |
| es-ES | Spanish (Spain) | Citomegalovirus: |
| es-MX | Spanish (Mexico) | Citomegalovirus: |
| fr-CA | French (Canada) | Cytomégalovirus: |
| fr-BE | French (Belgium) | Cytomégalovirus: Synonyms: CMV |
| fr-FR | French (France) | Cytomégalovirus: |
| it-IT | Italian (Italy) | Citomegalovirus: Synonyms: Coltura Shell vial Liquido amniotico Microbiologia Presenza o Soglia Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | Cytomegalovirus: |
| pl-PL | Polish (Poland) | Wirus cytomegalii: Synonyms: Cytomegalowirus |
| zh-CN | Chinese (China) | 巨细胞病毒: Synonyms: CMV; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=88624-2
Third Party Copyright
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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright