LOINC Panel Details 88883-4 Connective tissue autoimmune Ab panel

99065-5 Ej Ab [Units/volume] in Serum by Line blot

Part Descriptions

LP36852-9 Ej
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component: EJ Ab
Property: ACnc
Time: Pt
System: Ser
Scale: Qn
Method: Line blot

Additional Names

Short Name: Ej Ab Ser Line blot-aCnc
Display Name: Ej Ab Line blot Qn (S)
Consumer Name Alpha Get Info: Ej antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.72
Last Updated: Version 2.72
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG51674-6	EJ Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Ej Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot Synonyms: Cuantitativo
fr-CA	French (Canada)	Ej, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR	French (France)	Ej anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT	Italian (Italy)	Ej Ab:ACnc:Pt:Siero:Qn:Line blot Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	ej As:eenheid/volume:moment:serum:kwantitatief:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	Ej 抗体:任意型浓度:时间点:血清:定量型:线点印迹法 Synonyms: Ab;自身抗体 Ej Ab Glycyl-tRNA 合成酵素 Ab Glycyl-tRNA 合成酵素;Glycyl-tRNA 合成酶 Glycyl-tRNA 合成酵素抗体 Glycyl-tRNA 合成酶 Ab Glycyl-tRNA 合成酶抗体任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间用于先天性炎性肌病（idiopathic inflammatory myopathies.，先天性炎症性肌病）线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

58765-9 Histone Ab [Presence] in Serum by Immunoassay

Part Descriptions

LP16714-5 Histone
Histones are small nuclear proteins that together with dsDNA, represent a nucleosome, the structural unit of chromatin. Anti-histone antibodies are associated with various autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren's syndrome, systemic sclerosis, infectious diseases (including HIV), and some neurological disorders such as Alzheimer's disease and dementia. Nearly all patients with drug-induced SLE have anti-histone antibodies, but they are also present in patients with idiopathic forms of the disease. One study showed a correlation between SLE with positive anti-dsDNA, anti-nucleosome and anti-histone antibodies and renal disease, including proliferative glomerulonephritis. PMID: 24649358 Source: Regenstrief LOINC, PMID: 24649358

Fully-Specified Name

Component: Histone Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: IA

Additional Names

Short Name: Histone Ab Ser Ql IA
Display Name: Histone Ab IA Ql (S)
Consumer Name Alpha Get Info: Histone antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.32
Last Updated: Version 2.73
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 7203

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG21281-7	Histone Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Histona Anticuerpos:PrThr:Punto temporal:Suero:Ord:IA
es-MX	Spanish (Mexico)	Histona Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
et-EE	Estonian (Estonia)	Histoon antikehad:PrThr:Pt:S:Ord:IA Synonyms: Järgarvuline Juhuslik Seerum
fr-CA	French (Canada)	Histone, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR	French (France)	Histones anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	Histone Ac:PrThr:Temps ponctuel:Sérum:Ordinal:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Istone Ab:PrThr:Pt:Siero:Ord:IA Synonyms: anticorpo Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	histon As:aanwezigheid:moment:serum:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
pt-BR	Portuguese (Brazil)	Histona Ac::Pt:Soro:Ord:Imunoensaio
ru-RU	Russian (Russian Federation)	Гистон Ат:PrThr:ТчкВрм:Сыв:Пор:IA Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Histon Ab:MevcEşik:Zmlı:Ser:Srl:İA Synonyms: Ak İmmünölçüm, immünoassay Mevcut
zh-CN	Chinese (China)	组蛋白抗体:存在情况或阈值:时间点:血清:序数型:免疫测定法 Synonyms: Ab;自身抗体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间组朊组朊 Ab 组朊抗体组蛋白 Ab 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

5234-0 Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoassay

Part Descriptions

LP16719-4 Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component: Jo-1 extractable nuclear Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: IA

Additional Names

Short Name: ENA Jo1 Ab Ser Ql IA
Display Name: Jo-1 extractable nuclear Ab IA Ql (S)
Consumer Name Alpha Get Info: Jo-1 extractable nuclear antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 1.0
Last Updated: Version 2.73
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 3645

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG5369-6	Jo-1 extractable nuclear Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Jo-1 extrahierbarer nukleärer Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoassay Synonyms: Jo-1
es-AR	Spanish (Argentina)	[anticuerpo] antinuclear extraíble JO-1 [Ac]:concentración arbitraria:punto en el tiempo:suero:ordinal:enzimoinmunoanálisis
es-ES	Spanish (Spain)	Jo-1 Anticuerpos:PrThr:Punto temporal:Suero:Ord:IA
es-MX	Spanish (Mexico)	Ab nuclear extraíble Jo-1:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
fr-CA	French (Canada)	Jo-1 nucléaire soluble, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR	French (France)	Jo-1 anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	Jo-1 nucléaire soluble Ac:PrThr:Temps ponctuel:Sérum:Ordinal:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Jo-1, nucleare estraibile Ab:PrThr:Pt:Siero:Ord:IA Synonyms: anticorpo ENA Immunoassay Jo1 Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
ko-KR	Korean (Korea, Republic Of)	Jo-1 추출성 핵 항체:임의농도:검사시점:혈청:순위척도:효소면역측정법
nl-NL	Dutch (Netherlands)	jo-1 extraheerbaar nucleair As:aanwezigheid:moment:serum:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	Jo-1 rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:surowica:półilościowy:metoda immunologiczna Synonyms: Jo-1 rozpuszczalny jądrowy Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała przeciwjądrowe
pt-BR	Portuguese (Brazil)	Jo-1 Ac:ACnc:Pt:Soro:Ord:Imunoensaio Synonyms: ; ANA; ANF; NA; Antinuclear antibody; Nuc; ENA Jo1; Histidyl-tRNA synthease; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Enzyme immunoassay; ELISA; MEIA; SUDS; ELFA; IAA; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; I; Serology
ru-RU	Russian (Russian Federation)	Jo-1 экстрагируемый ядерный Ат:PrThr:ТчкВрм:Сыв:Пор:IA Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Jo-1 öztlenebilir çekirdek Ab:MevcEşik:Zmlı:Ser:Srl:İA Synonyms: Ak Çekirdek İmmünölçüm, immünoassay Mevcut
uk-UA	Ukrainian (Ukraine)	Jo-1 екстрагований ядерний Антитіла:Наявність або Поріг:МоментЧасу:Сироватка:Порядково:Імуноаналіз Synonyms: ABS; Aby; ANA; ANF; Antby; Anti; Antibodies; Antibody; Antinuclear antibody; Autoantibodies; Autoantibody; EIA; ELFA; ELISA; ENA; ENA Jo1; Enzyme immunoassay; Histidyl-tRNA synthease; i; IAA; MEIA; NA; Nuc; Ordinal; Point in time; PR; QL; Qual; Qualitative; Random; Screen; Serology; Serum; SR; SUDS; UniversalLabOrders
zh-CN	Chinese (China)	Jo-1 可提取性核抗体:存在情况或阈值:时间点:血清:序数型:免疫测定法 Synonyms: Ⅰ Ab;自身抗体 ANA ENA Ab ENA Jo1 Ab ENA Jo-1 Ab ENA Jo1 抗体 ENA Jo-1 抗体 ENA Jo1;ENA Jo-1;Jo-1 可提取性核 Ag;Jo-1 可提取性核抗原;可提取性核 Ag Jo1;可提取性核 Ag Jo-1;可提取性核抗原 Jo1;可提取性核抗原 Jo-1;组氨酰-tRNA 合成酶;组氨酰基-tRNA 合成酶 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 I Jo1 可提取性核 Ab Jo-1 可提取性核 Ab Jo1 可提取性核 Ag Ab Jo-1 可提取性核 Ag Ab Jo1 可提取性核抗体 Jo1 可提取性核抗原抗体 Jo-1 可提取性核抗原抗体 NA 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可提取性核 Ab 可提取性核 Ag Jo1 Ab 可提取性核 Ag Jo-1 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 Jo1 抗体可提取性核抗原 Jo-1 抗体可提取性核抗原之抗体存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）抗 ENA 抗可提取性核 Ag 抗可提取性核抗原抗核 Ab 抗核抗体抗核抗体（Antinuclear antibody，ANA）时刻;随机;随意;瞬间核;胞核细胞核 Ab 胞核 Ab 胞核抗体血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

99069-7 Jo-1 extractable nuclear Ab [Units/volume] in Serum by Line blot

Part Descriptions

LP16719-4 Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component: Jo-1 extractable nuclear Ab
Property: ACnc
Time: Pt
System: Ser
Scale: Qn
Method: Line blot

Additional Names

Short Name: ENA Jo1 Ab Ser Line blot-aCnc
Display Name: Jo-1 extractable nuclear Ab Line blot Qn (S)
Consumer Name Alpha Get Info: Jo-1 extractable nuclear antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.72
Last Updated: Version 2.72
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG352-1	Jo-1 extractable nuclear Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Jo-1 Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot Synonyms: Cuantitativo
fr-CA	French (Canada)	Jo-1 nucléaire soluble, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR	French (France)	Jo-1 anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT	Italian (Italy)	Jo-1, nucleare estraibile Ab:ACnc:Pt:Siero:Qn:Line blot Synonyms: anticorpo Concentrazione Arbitraria ENA Jo1 Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	jo-1 extraheerbaar nucleair As:eenheid/volume:moment:serum:kwantitatief:lijnblot Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	Jo-1 rozpuszczalny jądrowy Ab:stężenie w jednostkach umownych:punkt w czasie:surowica:ilościowy:line blot Synonyms: Jo-1 rozpuszczalny jądrowy Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała przeciwjądrowe
zh-CN	Chinese (China)	Jo-1 可提取性核抗体:任意型浓度:时间点:血清:定量型:线点印迹法 Synonyms: Ⅰ Ab;自身抗体 ANA ENA Ab ENA Jo1 Ab ENA Jo-1 Ab ENA Jo1 抗体 ENA Jo-1 抗体 ENA Jo1;ENA Jo-1;Jo-1 可提取性核 Ag;Jo-1 可提取性核抗原;可提取性核 Ag Jo1;可提取性核 Ag Jo-1;可提取性核抗原 Jo1;可提取性核抗原 Jo-1;组氨酰-tRNA 合成酶;组氨酰基-tRNA 合成酶 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 I Jo1 可提取性核 Ab Jo-1 可提取性核 Ab Jo1 可提取性核 Ag Ab Jo-1 可提取性核 Ag Ab Jo1 可提取性核抗体 Jo1 可提取性核抗原抗体 Jo-1 可提取性核抗原抗体 NA 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度可提取性核 Ab 可提取性核 Ag Jo1 Ab 可提取性核 Ag Jo-1 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 Jo1 抗体可提取性核抗原 Jo-1 抗体可提取性核抗原之抗体可用数量表示的;定量性;数值型;数量型;连续数值型标尺抗 ENA 抗可提取性核 Ag 抗可提取性核抗原抗核 Ab 抗核抗体抗核抗体（Antinuclear antibody，ANA）时刻;随机;随意;瞬间核;胞核线点杂交技术;线点杂交法;线条状印迹法细胞核 Ab 胞核 Ab 胞核抗体血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

99068-9 Ku Ab [Units/volume] in Serum by Line blot

Part Descriptions

LP19333-1 Ku
Ku antibody is a rare type of antinuclear antibody with either a speckled or nucleolar ANA pattern that is seen in several different autoimmune diseases. Source: Regenstrief LOINC

Fully-Specified Name

Component: Ku Ab
Property: ACnc
Time: Pt
System: Ser
Scale: Qn
Method: Line blot

Additional Names

Short Name: Ku Ab Ser Line blot-aCnc
Display Name: Ku Ab Line blot Qn (S)
Consumer Name Alpha Get Info: Ku antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.72
Last Updated: Version 2.72
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG51676-1	Ku Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Ku Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot Synonyms: Cuantitativo
fr-CA	French (Canada)	Ku, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR	French (France)	Ku anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT	Italian (Italy)	Ku Ab:ACnc:Pt:Siero:Qn:Line blot Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	ku As:eenheid/volume:moment:serum:kwantitatief:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	Ku 抗体:任意型浓度:时间点:血清:定量型:线点印迹法 Synonyms: Ab;自身抗体 Ku Ab Ku 抗原;Ku是一种大分子量不稳定酸性核蛋白抗原任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度先天性炎性肌病先天性炎症性肌病可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间特发性炎性肌病线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

99066-3 PL-12 Ab [Units/volume] in Serum by Line blot

Part Descriptions

LP30803-8 PL-12
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component: PL-12 Ab
Property: ACnc
Time: Pt
System: Ser
Scale: Qn
Method: Line blot

Additional Names

Short Name: PL12 Ab Ser Line blot-aCnc
Display Name: PL-12 Ab Line blot Qn (S)
Consumer Name Alpha Get Info: PL-12 antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.72
Last Updated: Version 2.72
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG51679-5	PL-12 Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Pl-12 Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot Synonyms: Cuantitativo
fr-CA	French (Canada)	Pl-12, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR	French (France)	PL-12 anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT	Italian (Italy)	PL-12 Ab:ACnc:Pt:Siero:Qn:Line blot Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	PL-12 As:eenheid/volume:moment:serum:kwantitatief:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	Pl-12 抗体:任意型浓度:时间点:血清:定量型:线点印迹法 Synonyms: Ab;自身抗体 Pl-12 Ab 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度先天性炎性肌病先天性炎症性肌病可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间特发性炎性肌病线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

99067-1 PL-7 Ab [Units/volume] in Serum by Line blot

Part Descriptions

LP30804-6 PL-7
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component: PL-7 Ab
Property: ACnc
Time: Pt
System: Ser
Scale: Qn
Method: Line blot

Additional Names

Short Name: PL7 Ab Ser Line blot-aCnc
Display Name: PL-7 Ab Line blot Qn (S)
Consumer Name Alpha Get Info: PL-7 antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.72
Last Updated: Version 2.72
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG51678-7	PL-7 Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Pl-7 Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot Synonyms: Cuantitativo
fr-CA	French (Canada)	Pl-7, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR	French (France)	PL-7 anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT	Italian (Italy)	PL-7 Ab:ACnc:Pt:Siero:Qn:Line blot Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	PL-7 As:eenheid/volume:moment:serum:kwantitatief:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	Pl-7 抗体:任意型浓度:时间点:血清:定量型:线点印迹法 Synonyms: Ab;自身抗体 Pl-7 Ab 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度先天性炎性肌病先天性炎症性肌病可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间特发性炎性肌病线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

89504-5 Ribosomal Ab [Presence] in Serum by Line blot

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Manufacturers call this method by different names, including immunoblot, line blot, and line immunoassay. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method for this term is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP18386-0 Ribosomal
A ribosome is an organelle in cells that assembles proteins. Ribosomes are composed of ribosomal RNA and ribosomal proteins (known as a Ribonucleoprotein or RNP). It translates Messenger RNA (mRNA) into a polypeptide chain (e.g., a protein). It can be thought of as a factory that builds a protein from a set of genetic instructions. Ribosomes can float freely in the cytoplasm (the internal fluid of the cell) or bind to the endoplasmic reticulum, or to the nuclear envelope. Since ribosomes are ribozymes, it is thought that they might be remnants of the RNA world. Ribosomes were first observed in the mid-1950s by cell biologist George Palade in the electron microscope as dense particles or granules for which he would win the Nobel Prize. The term ribosome was proposed by scientist Richard B. Roberts in 1958: During the course of the symposium a semantic difficulty became apparent. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Ribosomal (Wikipedia)

LP18386-0 Ribosomal
There are several ribosomal antigens. P (phospho) protein (P0, P1 & P2) is the most common. Other ribosomal antigens are L12 protein, L5/5s, S10, Ja, L7 and rRNA (ribosomal ribonucleoprotein) Source: Regenstrief Institute

Fully-Specified Name

Component: Ribosomal Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: Line blot

Additional Names

Short Name: Ribosomal Ab Ser Ql Line blot
Display Name: Ribosomal Ab Line blot Ql (S)
Consumer Name Alpha Get Info: Ribosomal antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.64
Order vs. Observation: Both

Example Answer List LL744-4

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG9626-5	Ribosomal Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Ribosomal Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX	Spanish (Mexico)	Ab ribosomal:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-FR	French (France)	Ribosomes anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
fr-CA	French (Canada)	Ribosomal, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
it-IT	Italian (Italy)	Ribosomiale Ab:PrThr:Pt:Siero:Ord:Line blot Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Ribosomi Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	ribosomaal As:aanwezigheid:moment:serum:ordinaal:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	核糖体抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法 Synonyms: Ab;自身抗体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间核糖体 Ab 核糖体的;核糖核蛋白体;核糖核蛋白体的;核蛋白体;核蛋白体的;核醣体核糖核蛋白体 Ab 核糖核蛋白体抗体核蛋白体 Ab 核蛋白体抗体核醣体 Ab 核醣体抗体线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

5348-8 SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoassay

Part Descriptions

LP16758-2 SCL-70 extractable nuclear
Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

Fully-Specified Name

Component: SCL-70 extractable nuclear Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: IA

Additional Names

Short Name: ENA Scl70 Ab Ser Ql IA
Display Name: SCL-70 extractable nuclear Ab IA Ql (S)
Consumer Name Alpha Get Info: SCL-70 extractable nuclear antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 1.0
Last Updated: Version 2.73
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 3439

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG5141-9	SCL-70 extractable nuclear Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	SCL-70 extrahierbarer nukleärer Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoassay Synonyms: Scl-70
es-AR	Spanish (Argentina)	SCL-70 nuclear extraíble:concentración arbitraria:punto en el tiempo:suero:ordinal:enzimoinmunoanálisis
es-ES	Spanish (Spain)	Antígeno nuclear extraíble SCL-70 Anticuerpos:PrThr:Punto temporal:Suero:Ord:IA
es-MX	Spanish (Mexico)	Ab nuclear extraíble SCL-70:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
fr-CA	French (Canada)	SCL-70 nucléaire soluble, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR	French (France)	SCL-70 anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	SCL-70 nucléaire soluble Ac:PrThr:Temps ponctuel:Sérum:Ordinal:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Nucleare estraibile SCL-70 Ab:PrThr:Pt:Siero:Ord:IA Synonyms: anticorpo ENA Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
ko-KR	Korean (Korea, Republic Of)	SCL-70 추출성 핵 항체:임의농도:검사시점:혈청:순위척도:효소면역측정법
nl-NL	Dutch (Netherlands)	SCL-70 extraheerbare nucleaire As:aanwezigheid:moment:serum:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	SCL-70 rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:surowica:półilościowy:metoda immunologiczna Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe SCL-70 rozpuszczalny jądrowy
pt-BR	Portuguese (Brazil)	SCL-70 Ac:ACnc:Pt:Soro:Ord:Imunoensaio Synonyms: ; ENA Scl70; Scleroderma Ac; ANA; ANF; NA; Antinuclear antibody; Nuc; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Enzyme immunoassay; ELISA; MEIA; SUDS; ELFA; IAA; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; Serology
ru-RU	Russian (Russian Federation)	SCL-70 экстрагируемый ядерный Ат:PrThr:ТчкВрм:Сыв:Пор:IA Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	SCL-70 özütlenebilir nükleer Ab:MevcEşik:Zmlı:Ser:Srl:İA Synonyms: Ak Çekirdek İmmünölçüm, immünoassay Mevcut
uk-UA	Ukrainian (Ukraine)	SCL-70 екстраговані нуклеарні, Антитіла:Наявність або Поріг:МоментЧасу:Сироватка:Порядково:Імуноаналіз Synonyms: ABS; Aby; ANA; ANF; Antby; Anti; Antibodies; Antibody; Antinuclear antibody; anti-topo I; Autoantibodies; Autoantibody; DNA-Topoisomerase I; EIA; ELFA; ELISA; ENA; ENA Scl70; Enzyme immunoassay; IAA; MEIA; NA; Nuc; Ordinal; Point in time; PR; QL; Qual; Qualitative; Random; Scleroderma; Scleroderma ab; Screen; Serology; Serum; SR; SUDS; Topo I; Topoisomerase I; UniversalLabOrders
zh-CN	Chinese (China)	SCL-70 可提取性核抗体:存在情况或阈值:时间点:血清:序数型:免疫测定法 Synonyms: Ab;自身抗体 ANA ENA Ab ENA SCL-70 Ab ENA SCL-70 抗体 ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA SCL-70 可提取性核 Ab SCL-70 可提取性核 Ag Ab SCL-70 可提取性核抗原抗体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原 SCL-70 Ab 可提取性核抗原 SCL-70 抗体可提取性核抗原之抗体存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）抗 ENA 抗可提取性核 Ag 抗可提取性核抗原抗核 Ab 抗核抗体抗核抗体（Antinuclear antibody，ANA）时刻;随机;随意;瞬间核;胞核皮硬化症硬皮病硬皮病（Scleroderma，SCL）硬皮症细胞核 Ab 胞核 Ab 胞核抗体血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

63342-0 Sjogrens syndrome-A extractable nuclear 52kD Ab [Presence] in Serum by Immunoassay

Part Descriptions

LP69895-8 Sjogrens syndrome-A extractable nuclear 52kD
Antibodies against the 52-kd Ro(SS-A) protein are significantly associated with the primary Sjogren's syndrome (pSS). Source: Regenstrief LOINC

Fully-Specified Name

Component: Sjogrens syndrome-A extractable nuclear 52kD Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: IA

Additional Names

Short Name: ENA SS-A 52kD Ab Ser Ql IA
Display Name: Sjogrens syndrome-A extractable nuclear 52kD Ab IA Ql (S)
Consumer Name Alpha Get Info: Sjogrens syndrome-A extractable nuclear 52kD antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.36
Last Updated: Version 2.56
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG21387-2	Sjogrens syndrome-A extractable nuclear 52kD Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Sjögren-Syndrom-A extrahierbarer nukleärer 52kD Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoassay
es-ES	Spanish (Spain)	Ag extraible nuclear de 52 kD del Síndrome de Sjogrens Anticuerpos:PrThr:Punto temporal:Suero:Ord:IA
es-MX	Spanish (Mexico)	Síndrome de Sjogrens:Ab nuclear extraíble de 52 kD:Presencia o umbral:Punto temporal:Suero:Ordinal
fr-CA	French (Canada)	Syndrome de Sjögren-a nucléaire soluble 52kD, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR	French (France)	SSA/Ro52 kD anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	Syndrome de Sjögren-a nucléaire soluble 52kD Ac:PrThr:Temps ponctuel:Sérum:Ordinal:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Sjogren, sindrome -nucleare estraibile A 52kD Ab:PrThr:Pt:Siero:Ord:IA Synonyms: anticorpo ENA Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Sindrome di Sjorgen - nucleare estraibile A Sindrome di Sjorgen - nucleare estraibile A 52kD
nl-NL	Dutch (Netherlands)	syndroom van Sjögren-A extraheerbare nucleaire 52kD As:aanwezigheid:moment:serum:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
ru-RU	Russian (Russian Federation)	Шегрена синдром-A экстрагируемый ядерный 52кД Ат:PrThr:ТчкВрм:Сыв:Пор:IA Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Sjögrens sendromu-A özütlenebilir nükleer 52kD Ab:MevcEşik:Zmlı:Ser:Srl:İA Synonyms: Ak Çekirdek İmmünölçüm, immünoassay Mevcut
zh-CN	Chinese (China)	Sjogrens 综合征-a 可提取性核 52kD 抗体:存在情况或阈值:时间点:血清:序数型:免疫测定法 Synonyms: A 型 Ab;自身抗体 ENA SS-A;Ro;Ro AB;Ro 抗体;Ro 抗原;Sjogren;Sjogrens 综合征-a ENA;Sjogrens 综合征-a 可提取性核 Ag;Sjogrens 综合征-a 可提取性核抗原;SSA;SS-A;干燥综合征-a 抗原 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 Sjogren 氏综合征 Sjogren 综合征 Sjogren's 综合征 SS 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）干燥综合征干燥综合征（Sjogrens syndrome，SS）时刻;随机;随意;瞬间核;胞核血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

99139-8 Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum by Line blot

Part Descriptions

LP69895-8 Sjogrens syndrome-A extractable nuclear 52kD
Antibodies against the 52-kd Ro(SS-A) protein are significantly associated with the primary Sjogren's syndrome (pSS). Source: Regenstrief LOINC

Fully-Specified Name

Component: Sjogrens syndrome-A extractable nuclear 52kD Ab
Property: ACnc
Time: Pt
System: Ser
Scale: Qn
Method: Line blot

Additional Names

Short Name: ENA SS-A 52kD Ab Ser Line blot-aCnc
Display Name: Sjogrens syndrome-A extractable nuclear 52kD Ab Line blot Qn (S)
Consumer Name Alpha Get Info: Sjogrens syndrome-A extractable nuclear 52kD antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.72
Last Updated: Version 2.72
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG21388-0	Sjogrens syndrome-A extractable nuclear 52kD Ab\|ACnc\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Ag extraible nuclear de 52 kD del Síndrome de Sjogrens Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot Synonyms: Cuantitativo
fr-CA	French (Canada)	Syndrome de Sjögren-a nucléaire soluble 52kD, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR	French (France)	SSA/Ro52 kD anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT	Italian (Italy)	Sjogren, sindrome -nucleare estraibile A 52kD Ab:ACnc:Pt:Siero:Qn:Line blot Synonyms: anticorpo Concentrazione Arbitraria ENA Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Sindrome di Sjorgen - nucleare estraibile A Sindrome di Sjorgen - nucleare estraibile A 52kD
nl-NL	Dutch (Netherlands)	syndroom van Sjögren-A extraheerbare nucleaire 52kD As:eenheid/volume:moment:serum:kwantitatief:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	Sjogrens 综合征-a 可提取性核 52kD 抗体:任意型浓度:时间点:血清:定量型:线点印迹法 Synonyms: A 型 Ab;自身抗体 ENA SS-A;Ro;Ro AB;Ro 抗体;Ro 抗原;Sjogren;Sjogrens 综合征-a ENA;Sjogrens 综合征-a 可提取性核 Ag;Sjogrens 综合征-a 可提取性核抗原;SSA;SS-A;干燥综合征-a 抗原 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 Sjogren 氏综合征 Sjogren 综合征 Sjogren's 综合征 SS 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度可用数量表示的;定量性;数值型;数量型;连续数值型标尺干燥综合征干燥综合征（Sjogrens syndrome，SS）时刻;随机;随意;瞬间核;胞核线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

63411-3 Sjogrens syndrome-A extractable nuclear 60kD Ab [Presence] in Serum by Immunoassay

Part Descriptions

LP69893-3 Sjogrens syndrome-A extractable nuclear 60kD Ab
Antibodies against the 60-kD Ro (or SS-A) are commonly found in patients with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Source: Regenstrief LOINC

Fully-Specified Name

Component: Sjogrens syndrome-A extractable nuclear 60kD Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: IA

Additional Names

Short Name: ENA SS-a 60kD Ab Ser Ql IA
Display Name: Sjogrens syndrome-A extractable nuclear 60kD Ab IA Ql (S)
Consumer Name Alpha Get Info: Sjogrens syndrome-A extractable nuclear 60kD antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.36
Last Updated: Version 2.73
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 10958

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG21389-8	Sjogrens syndrome-A extractable nuclear 60kD Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Sjögren-Syndrom-A extrahierbarer nukleärer 60kD Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoassay
es-ES	Spanish (Spain)	Ag extraible nuclear de 60 kD del Síndrome de Sjogrens Anticuerpos:PrThr:Punto temporal:Suero:Ord:IA
es-MX	Spanish (Mexico)	Síndrome de Sjogrens:Ab nuclear extraíble de 60 kD:Presencia o umbral:Punto temporal:Suero:Ordinal
fr-CA	French (Canada)	Syndrome de Sjögren-a nucléaire soluble 60kD, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR	French (France)	SSA/Ro60 kD anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	Syndrome de Sjögren-a nucléaire soluble 60kD Ac:PrThr:Temps ponctuel:Sérum:Ordinal:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Sjorgen, sindrome-nucleare estraibile A 60kD Ab:PrThr:Pt:Siero:Ord:IA Synonyms: anticorpo ENA Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Sindrome di Sjorgen - nucleare estraibile A Sindrome di Sjorgen - nucleare estraibile A 60kD
nl-NL	Dutch (Netherlands)	syndroom van Sjögren-A extraheerbare nucleaire 60kD As:aanwezigheid:moment:serum:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
ru-RU	Russian (Russian Federation)	Шегрена синдром-A экстрагируемый ядерный 60кД Ат:PrThr:ТчкВрм:Сыв:Пор:IA Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Sjögrens sendromu-A özütlenebilir nükleer 60kD Ab:MevcEşik:Zmlı:Ser:Srl:İA Synonyms: Ak Çekirdek İmmünölçüm, immünoassay Mevcut
zh-CN	Chinese (China)	Sjogrens 综合征-a 可提取性核 60kD 抗体:存在情况或阈值:时间点:血清:序数型:免疫测定法 Synonyms: A 型 Ab;自身抗体 ENA SS-A;Ro;Ro AB;Ro 抗体;Ro 抗原;Sjogren;Sjogrens 综合征-a ENA;Sjogrens 综合征-a 可提取性核 Ag;Sjogrens 综合征-a 可提取性核抗原;SSA;SS-A;干燥综合征-a 抗原 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 Sjogren 氏综合征 Sjogren 综合征 Sjogren's 综合征 SS 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）干燥综合征干燥综合征（Sjogrens syndrome，SS）时刻;随机;随意;瞬间核;胞核血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

5353-8 Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoassay

Part Descriptions

LP16761-6 Sjogrens syndrome-B extractable nuclear
Sjogren syndrome type A antigen (also known as SS-A, Ro, and E3 ubiquitin-protein ligase TRIM21) and Sjogren syndrome type B antigen (also known as SS-B and Lupus La protein) are nuclear antigens to which autoantibodies develop in autoimmune disorders such as Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE). Between 40 and 70% of patients with SS have anti-SSA and/or anti-SSB autoantibodies, and 30-40% and 10-15% of patients with SLE are anti-SSA and anti-SSB positive, respectively. Longitudinal studies have shown that anti-SSA and -SSB antibodies may be present up to 20 years before the clinical onset of disease. SS patients who are anti-SSA and anti-SSB positive may have longer disease duration, parotid gland enlargement, decreased salivary flow, more severe minor salivary gland infiltration and a higher prevalence of extraglandular manifestations. PMID: 27184054 Source: Regenstrief LOINC, PMID: 27184054

Fully-Specified Name

Component: Sjogrens syndrome-B extractable nuclear Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: IA

Additional Names

Short Name: ENA SS-B Ab Ser Ql IA
Display Name: Sjogrens syndrome-B extractable nuclear Ab IA Ql (S)
Consumer Name Alpha Get Info: Sjogrens syndrome-B extractable nuclear antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 1.0
Last Updated: Version 2.73
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 841

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG5160-9	Sjogrens syndrome-B extractable nuclear Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Sjögren-Syndrom-B extrahierbarer nukleärer Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoassay Synonyms: SSB; SS-B
el-GR	Greek (Greece)	Αντι-La (SSB) Αντίσωμα:PrThr:Χρονική στιγμή:Ορός:Τακτική:IA Synonyms: Ab
es-AR	Spanish (Argentina)	síndrome de Sjögren-B nuclear extraíble:concentración arbitraria:punto en el tiempo:suero:ordinal:enzimoinmunoanálisis
es-ES	Spanish (Spain)	Antígeno nuclear extraíble Síndrome de Sjogren-B (SS-B) Anticuerpos:PrThr:Punto temporal:Suero:Ord:IA
es-MX	Spanish (Mexico)	Ab nuclear extraíble con síndrome de Sjogrens-B:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
fr-CA	French (Canada)	Syndrome de Sjögren-b nucléaire soluble, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-FR	French (France)	SSB/La anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	Syndrome de Sjögren-b nucléaire soluble Ac:PrThr:Temps ponctuel:Sérum:Ordinal:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Sjogren, sindrome-nucleare estraibile B Ab:PrThr:Pt:Siero:Ord:IA Synonyms: anticorpo ENA Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant Sindrome di Sjorgen - nucleare estraibile B
ko-KR	Korean (Korea, Republic Of)	쇼그렌 증후군-B 추출성 핵 항체:임의농도:검사시점:혈청:순위척도:효소면역측정법
nl-NL	Dutch (Netherlands)	SS-B extraheerbare nucleaire As:aanwezigheid:moment:serum:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	Zespół Sjogrena-B rozpuszczalny jądrowy Ab:granica wykrywalności:punkt w czasie:surowica:półilościowy:metoda immunologiczna Synonyms: Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała przeciwjądrowe
pt-BR	Portuguese (Brazil)	SS-B Ac:ACnc:Pt:Soro:Ord:Imunoensaio Synonyms: ; ENA SS-B; Sjogren; SSB; La Ac; HA; Ha Ac; ANA; ANF; NA; Antinuclear antibody; Nuc; Arbitrary concentration; Point in time; Random; Serum; SR; Ql; Ordinal; QL; Qualitative; Qual; Screen; Enzyme immunoassay; ELISA; MEIA; SUDS; ELFA; IAA; Antibodies; Autoantibody; Antibody; Autoantibodies; Antby; Acy; Anti; SS; Serology
ru-RU	Russian (Russian Federation)	Шегрена синдром-B экстрагируемый ядерный Ат:PrThr:ТчкВрм:Сыв:Пор:IA Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Sjogrens sendromu-B özütlenebilir nükleer Ab:MevcEşik:Zmlı:Ser:Srl:İA Synonyms: Ak Çekirdek İmmünölçüm, immünoassay Mevcut
zh-CN	Chinese (China)	Sjogrens 综合征-b 可提取性核抗体:存在情况或阈值:时间点:血清:序数型:免疫测定法 Synonyms: Ab;自身抗体 ANA B 型 ENA Ab ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 NA Sjogren 氏综合征 Sjogren 综合征 Sjogren's 综合征 Sjogrens 综合征-b ENA Ab Sjogrens 综合征-b ENA Ag Ab Sjogrens 综合征-b ENA 抗体 Sjogrens 综合征-b ENA 抗原抗体 Sjogrens 综合征-b ENA;Sjogrens 综合征-b ENA Ag;Sjogrens 综合征-b ENA 抗原;Sjogrens 综合征-b 可提取性核 Ag;Sjogrens 综合征-b 可提取性核抗原;SSB;SS-B;SSB Ag;SS-B Ag;SSB 抗原;SS-B 抗原;干燥综合征-b Ag;干燥综合征-b 抗原 Sjogrens 综合征-b 可提取性核 Ab Sjogrens 综合征-b 可提取性核 Ag Ab Sjogrens 综合征-b 可提取性核抗原之抗体 Sjogrens 综合征-b 可提取性核抗原抗体 SS SSB Ab SS-B Ab SSB Ag Ab SS-B Ag Ab SSB 抗体 SS-B 抗体 SSB 抗原抗体 SS-B 抗原抗体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可提取性核 Ab 可提取性核 Ag 之 Ab 可提取性核抗原之抗体存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）干燥综合征干燥综合征（Sjogrens syndrome，SS）干燥综合征-b Ag Ab 干燥综合征-b 抗原之抗体干燥综合征-b 抗原抗体抗 ENA 抗可提取性核 Ag 抗可提取性核抗原抗核 Ab 抗核抗体抗核抗体（Antinuclear antibody，ANA）时刻;随机;随意;瞬间核;胞核细胞核 Ab 胞核 Ab 胞核抗体血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

88882-6 Smith extractable nuclear B Ab [Presence] in Serum by Line blot

Term Description

This test was created for, but not limited to, the INNO-LIA ANA Update test kit, which is a line immunoassay for the detection and identification of thirteen antinuclear antibodies (ANA) in human serum to aid in the diagnosis of connective tissue disorders.
Source: Regenstrief LOINC

Part Descriptions

LP71697-4 Smith extractable nuclear B Ab
Smith extractable nuclear B antibody binds to the B protein, which is one of the seven proteins that constitute the core of small nuclear ribonucleoprotein (snRNP) particles and include U1, U2, U4, and U5. Smith antibodies (anti-Sm) are present in 5-30% of patient who are positive for systemic lupus erythematosus (SLE). Anti-Sm is highly specific for SLE and their presence is part of the serological protocol for the diagnosis of SLE. In addition to its importance in the diagnosis of SLE, anti-Sm are also associated with how active and severe any renal involvement may be. PMID: 15804705 Source: Regenstrief LOINC

Fully-Specified Name

Component: Smith extractable nuclear B Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: Line blot

Additional Names

Short Name: ENA SM-B Ab Ser Ql Line blot
Display Name: Smith extractable nuclear B Ab Line blot Ql (S)
Consumer Name Alpha Get Info: Smith Extractable Nuclear B antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.64
Order vs. Observation: Both

Example Answer List LL360-9

Answer	Code	Score	Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG50058-3	Smith extractable nuclear B Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: SmB-AK qual. IB
es-ES	Spanish (Spain)	Smith nuclear extraíble B Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX	Spanish (Mexico)	Smith extraíble nuclear B Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-FR	French (France)	Sm B anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
fr-CA	French (Canada)	Smith nucléaire soluble B, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
it-IT	Italian (Italy)	Smith, nucleari estraibili B Ab:PrThr:Pt:Siero:Ord:Line blot Synonyms: anticorpo ENA Nucleare estraibile Smith Nucleari estraibili Smith B Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	Smith extraheerbare nucleaire B As:aanwezigheid:moment:serum:ordinaal:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	Smith 可提取性核 B 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法 Synonyms: Ab;自身抗体 B 型 B型抗体 ENA SM;ENA SM Ag;ENA SM 抗原;ENA Smith;SM;SM Ag;SM 抗原;Smith ENA;Smith 可提取性核 Ag;Smith 可提取性核抗原;可提取性核抗原 Smith ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间核;胞核线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

88881-8 Smith extractable nuclear D Ab [Presence] in Serum by Line blot

Term Description

This test was created for, but not limited to, the INNO-LIA ANA Update test kit, which is a line immunoassay for the detection and identification of thirteen antinuclear antibodies (ANA) in human serum to aid in the diagnosis of connective tissue disorders.
Source: Regenstrief LOINC

Part Descriptions

LP71718-8 Smith extractable nuclear D
Smith extractable nuclear D (Sm-D) antibodies target Sm-D proteins, which are among the 7 Sm proteins (B/B', D1, D2, D3, E, F, G) that constitute the common core of U1, U2, U4 and U5 small nuclear ribonucleoprotein (snRNP). SmD is a mixture of D1, D2, and D3. Of these, D1 and D3 are among those more frequently targeted by Anti-Sm antibodies. PMID: 15804705 Anti-Sm antibodies are a type of extractable nuclear antigens (ENA) antibodies that cause a variety of autoimmune diseases, including systemic lupus erythematosus (SLE). PMCID: PMC119916 Source: Regenstrief LOINC

Fully-Specified Name

Component: Smith extractable nuclear D Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: Line blot

Additional Names

Short Name: ENA SM-D Ab Ser Ql Line blot
Display Name: Smith extractable nuclear D Ab Line blot Ql (S)
Consumer Name Alpha Get Info: Smith Extractable Nuclear D antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.64
Last Updated: Version 2.64
Order vs. Observation: Both

Example Answer List LL360-9

Answer	Code	Score	Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG50059-1	Smith extractable nuclear D Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: SmD-AK qual. IB
es-ES	Spanish (Spain)	Smith nuclear extraíble C Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX	Spanish (Mexico)	Smith extraíble nuclear D Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-FR	French (France)	Sm D anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
fr-CA	French (Canada)	Smith nucléaire soluble D, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
it-IT	Italian (Italy)	Smith, nucleari estraibili D Ab:PrThr:Pt:Siero:Ord:Line blot Synonyms: anticorpo ENA Nucleare estraibile Smith Nucleari estraibili Smith D Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	Smith extraheerbare nucleaire D As:aanwezigheid:moment:serum:ordinaal:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	Smith 可提取性核 D 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法 Synonyms: Ab;自身抗体 D 型抗体 ENA SM;ENA SM Ag;ENA SM 抗原;ENA Smith;SM;SM Ag;SM 抗原;Smith ENA;Smith 可提取性核 Ag;Smith 可提取性核抗原;可提取性核抗原 Smith ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原（Extractable Nuclear Antigen，ENA）;可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 Rh;Rhesus;恒河猴;猕猴;罗猴依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间核;胞核线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

82450-8 U1 small nuclear ribonucleoprotein 70kD Ab [Presence] in Serum by Line blot

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP69897-4 U1 small nuclear ribonucleoprotein 70kD
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

Fully-Specified Name

Component: U1 small nuclear ribonucleoprotein 70kD Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: Line blot

Additional Names

Short Name: U1 snRNP70 Ab Ser Ql Line blot
Display Name: U1 small nuclear ribonucleoprotein 70kD Ab Line blot Ql (S)
Consumer Name Alpha Get Info: U1 small nuclear ribonucleoprotein 70kD antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.58
Last Updated: Version 2.66
Change Reason: This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation: Both

Example Answer List LL360-9

Answer	Code	Score	Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG21400-3	U1 small nuclear ribonucleoprotein 70kD Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: U1-snRNP-70-AK qual. IA
es-ES	Spanish (Spain)	U1 ribonucleoproteína nuclear pqueña de 70kD Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX	Spanish (Mexico)	Ribonucleoproteína nuclear sub U1 70kD Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CA	French (Canada)	Petite particule nucléaire ribonucléoprotéique U1 70kD, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FR	French (France)	U1 RNP 70kD anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-IT	Italian (Italy)	U1, piccola ribonucleoproteina nucleare 70kD Ab:PrThr:Pt:Siero:Ord:Line blot Synonyms: anticorpo Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 70kD Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	u1 small nucleair ribonucleoproteïne 70kD As:aanwezigheid:moment:serum:ordinaal:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	U1 小细胞核核糖核蛋白 70kD 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法 Synonyms: Ab;自身抗体 RNP snRNP U1 RNP 70kD;U1 snRNP 70kD;U1 小细胞核核糖核蛋白 70kD;U1 small nuclear ribonucleoprotein 70kD;U1RNP 70kD U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）小分子核糖核蛋白体小分子细胞核核糖核蛋白小核核糖核蛋白（Small nuclear ribonucleoprotein，snRNP）时刻;随机;随意;瞬间核;胞核核内小核糖核蛋白核微小核糖核蛋白核糖核蛋白（Ribonucleoprotein，Ribonuclear protein，RNP）核蛋白线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

82451-6 U1 small nuclear ribonucleoprotein A Ab [Presence] in Serum by Line blot

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP71719-6 U1 small nuclear ribonucleoprotein A
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

Fully-Specified Name

Component: U1 small nuclear ribonucleoprotein A Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: Line blot

Additional Names

Short Name: U1 snRNP-A Ab Ser Ql Line blot
Display Name: U1 small nuclear ribonucleoprotein A Ab Line blot Ql (S)
Consumer Name Alpha Get Info: U1 Small Nuclear Ribonucleoprotein A antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.58
Last Updated: Version 2.66
Change Reason: This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation: Both

Example Answer List LL360-9

Answer	Code	Score	Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG21924-2	U1 small nuclear ribonucleoprotein A Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: U1-snRNP-A-AK ql. IA
es-ES	Spanish (Spain)	U1 ribonucleoproteína nuclear pequeña A Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX	Spanish (Mexico)	U1 ribonucleoproteína nuclear sub A Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CA	French (Canada)	Petite particule nucléaire ribonucléoprotéique U1 A, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FR	French (France)	U1 RNP A anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-IT	Italian (Italy)	U1, piccola ribonucleoproteina nucleare A Ab:PrThr:Pt:Siero:Ord:Line blot Synonyms: anticorpo Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 A Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	u1 small nucleair ribonucleoproteïne A As:aanwezigheid:moment:serum:ordinaal:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	U1 小细胞核核糖核蛋白 A 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法 Synonyms: A 型 A 型抗体 Ab;自身抗体 RNP snRNP U1 RNP A;U1 snRNP A;U1 小细胞核核糖核蛋白 A;U1 small nuclear ribonucleoprotein A;U1RNP A U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）小分子核糖核蛋白体小分子细胞核核糖核蛋白小核核糖核蛋白（Small nuclear ribonucleoprotein，snRNP）时刻;随机;随意;瞬间核;胞核核内小核糖核蛋白核微小核糖核蛋白核糖核蛋白（Ribonucleoprotein，Ribonuclear protein，RNP）核蛋白线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

82452-4 U1 small nuclear ribonucleoprotein C Ab [Presence] in Serum by Line blot

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP71712-1 U1 small nuclear ribonucleoprotein C
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

Fully-Specified Name

Component: U1 small nuclear ribonucleoprotein C Ab
Property: PrThr
Time: Pt
System: Ser
Scale: Ord
Method: Line blot

Additional Names

Short Name: U1 snRNP-C Ab Ser Ql Line blot
Display Name: U1 small nuclear ribonucleoprotein C Ab Line blot Ql (S)
Consumer Name Alpha Get Info: U1 Small Nuclear Ribonucleoprotein C antibody, Blood

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.58
Last Updated: Version 2.66
Change Reason: This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation: Both

Example Answer List LL360-9

Answer	Code	Score	Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Member of these Panels

LOINC	Long Common Name
88883-4	Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG21917-6	U1 small nuclear ribonucleoprotein C Ab\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: U1-snRNP-C-AK ql. IA
es-ES	Spanish (Spain)	U1 ribonucleoproteína nuclear pequeña C Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX	Spanish (Mexico)	U1 ribonucleoproteína nuclear sub C Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CA	French (Canada)	Petite particule nucléaire ribonucléoprotéique U1 C, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FR	French (France)	U1 RNP C anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-IT	Italian (Italy)	U1, piccola ribonucleoproteina nucleare C Ab:PrThr:Pt:Siero:Ord:Line blot Synonyms: anticorpo Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 C Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	u1 small nucleair ribonucleoproteïne C As:aanwezigheid:moment:serum:ordinaal:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	U1 小细胞核核糖核蛋白 C 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法 Synonyms: Ab;自身抗体 C 型;丙;丙型 C 型抗体 RNP snRNP U1 RNP C;U1 snRNP C;U1 小细胞核核糖核蛋白 C;U1 small nuclear ribonucleoprotein C;U1RNP C U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）小分子核糖核蛋白体小分子细胞核核糖核蛋白小核核糖核蛋白（Small nuclear ribonucleoprotein，snRNP）时刻;随机;随意;瞬间核;胞核核内小核糖核蛋白核微小核糖核蛋白核糖核蛋白（Ribonucleoprotein，Ribonuclear protein，RNP）核蛋白线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

88883-4

Connective tissue autoimmune Ab panel - Serum

Active

99065-5 Ej Ab [Units/volume] in Serum by Line blot

Part Descriptions

Fully-Specified Name

Additional Names

Basic Attributes

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

Example Units

58765-9 Histone Ab [Presence] in Serum by Immunoassay

Part Descriptions

Fully-Specified Name

Additional Names

Basic Attributes

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

5234-0 Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoassay

Part Descriptions

Fully-Specified Name

Additional Names

Basic Attributes

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

99069-7 Jo-1 extractable nuclear Ab [Units/volume] in Serum by Line blot

Part Descriptions

Fully-Specified Name

Additional Names

Basic Attributes

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

Example Units

99068-9 Ku Ab [Units/volume] in Serum by Line blot

Part Descriptions

Fully-Specified Name

Additional Names

Basic Attributes

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

Example Units

99066-3 PL-12 Ab [Units/volume] in Serum by Line blot

Part Descriptions

Fully-Specified Name

Additional Names

Basic Attributes

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

Example Units

99067-1 PL-7 Ab [Units/volume] in Serum by Line blot

Part Descriptions

Fully-Specified Name

Additional Names

Basic Attributes

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

Example Units

89504-5 Ribosomal Ab [Presence] in Serum by Line blot

Term Description

Part Descriptions

Fully-Specified Name

Additional Names

Basic Attributes

Example Answer List LL744-4

Member of these Panels

Member of these Groups Get Info