1765-7 Aldosterone [Mass/time] in 24 hour Urine

Part Descriptions

LP14377-3   Aldosterone
Aldosterone is a steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Acting on mineralocorticoid receptors (MR) on principal cells in the collecting ducts of the kidneys, it increases the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. Aldosterone also stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3-) levels and its acidbase balance. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Aldosterone (Wikipedia)

LP14377-3   Aldosterone
Used to detect hyper and hypo aldosteronisnm. Hypoaldosteronism can occur in any condition that causes destruction or dysfunction of the adrenal gland.1,2,4 Hypoaldosterism can be due to primary adrenal insufficiency , congenital adrenal hypoplasia, acquired secondary aldosterone deficiency (hyporeninemic hypoaldosteronism), and acquired Hyporeninemic hypoaldosteronism is the most common form of isolated hypoaldosteronism and is results from impaired renin release from the kidney. Congenital hypoaldosteronism caused by inherited enzymatic defects in aldosterone biosynthesis are rare. Corticosterone methyloxidase I (CMO I) deficiency is associated with elevated serum levels of corticosterone and low levels of 18-hydroxy-corticosterone and aldosterone. Corticosterone methyloxidase II (CMO II) deficiency produces high levels of 18-hydroxy-corticosterone, the immediate precursor of aldosterone.
Acquired primary hypoaldosteronism can be caused by the administration of heparin. Also, persistently hypotensive, critically ill patients with sepsis, pneumonia, peritonitis, cholangitis, and liver failure can have inappropriately low plasma aldosterone concentrations in relation to elevated plasma renin activity. Primary hyperaldosteronism, also referred to as Conn syndrome, is due to overproduction of aldosterone by one or both of the adrenal glands. Some recent studies suggest that 10% to 15% of Hyper thyroidism cases are due to (or associated with ) primary hyperaldosteronism. Secondary hyperaldosteronism is relatively common and can occur as the result of any condition that decreases blood flow to the kidneys (ie, renal artery stenosis), decreases blood pressure, or lowers plasma sodium levels. Secondary hyperaldosteronism may also be seen with cirrhosis, congestive heart failure. and toxemia of pregnancy. Several studies have suggested that high-normal aldosterone levels predict development of high blood pressure in normotensive subjects and that increased aldosterone action contributes to hypertension, cardiovascular fibrosis, and cardiac hypertrophy. Source: Regenstrief Institute

Fully-Specified Name

Component

Aldosterone

Property

MRat

Time

24H

System

Urine

Scale

Qn

Method

Additional Names

Short Name

Aldost 24h Ur-mRate

Display Name

Aldosterone (24H U) [Mass/Time]

Consumer Name Alpha Get Info

Aldosterone, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

4595

Member of these Panels

Language Variants Get Info

Related Names

• 1 day
• 24 hours
• 24HR
• Chemistry
• Endocrine
• Endocrinology
• Mass Rate
• mRate
• QNT
• Quan
• Quant
• Quantitative
• UA
• UR
• Urn

Example Units

2956-1 Sodium [Moles/time] in 24 hour Urine

Part Descriptions

LP15099-2   Sodium
Sodium (Na) is a positively charged electrolyte and a mineral. Eighty-five percent of Na is located in the blood and lymph fluid. The hormone aldosterone that is secreted by the adrenal glands helps to regulate Na levels by signaling the kidneys to either retain or secrete it. Damage or disease to the kidneys can lead to dangerous fluctuations of sodium. Na plays a number of key roles in the homeostasis of the human body. It helps to maintain blood volume by osmotically pulling water into the blood vessels. Too much sodium in the blood may cause too much water to be brought into the blood vessels and lead to high blood pressure. Muscles and nerves conduct electrical impulses that require charged particles including Na. The electrical currents cause muscle cells to contract and nerve cells to relay electrical signals between them. Too little sodium can lead to muscle spasms, cramps, headache, irritability, restlessness, nausea and fatigue. Extreme hyponatremia can lead to confusion, hallucinations, decreased consciousness and coma. Conversely, hypernatremia can cause lethargy or restlessness, deep tendon reflexes, muscle spasticity and seizures. Source: Regenstrief LOINC, Sodium healthy eating

Fully-Specified Name

Component

Sodium

Property

SRat

Time

24H

System

Urine

Scale

Qn

Method

Additional Names

Short Name

Sodium 24h Ur-sRate

Display Name

Sodium (24H U) [Moles/Time]

Consumer Name Alpha Get Info

Sodium, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 1.0

Last Updated

Version 2.73

Order vs. Observation

Both

Common Test Rank Get Info

2069

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• 1 day
• 24 hours
• 24HR
• Chemistry
• Kidney
• Na
• Na+
• Nephrology
• QNT
• Quan
• Quant
• Quantitative
• Renal
• sRate
• Substance Rate
• UA
• UniversalLabOrders
• UR
• Urn

Example Units