Version 2.78

87755-5 Clostridioides difficile BI-NAP1-027 strain DNA [Presence] in Stool by NAA with probe detection

Part Descriptions

LP263522-7   Clostridioides difficile BI-NAP1-027 strain
Clostridium difficile (CD) infections in hospitals across the United States, Canada and Europe experienced an enormous increase between 2000 and 2006. The pathogen that was found to cause this outbreak was the strain of CD determined by restriction endonuclease analysis (REA) to be toxin type III, restriction endonuclease analysis (REA) group B1; by pulsed-field gel electrophoresis as North American pulsed-field type NAP1; and by polymerase chain reaction (PCR) ribotyping as type 027. The strain is identified as Clostridium difficile BI/NAP1/027 or NAP1. The NAP1 strain of CD produces increased levels of three toxins, the usual toxins A and B, and a binary toxin. A mutation of the toxin A and B suppressor gene tcdC may explain the increased production of toxin. It is also strongly resistant to treatment with fluoroquinolone antibiotics. CD NAP1 is not a new strain of CD. It was isolated between 1984 and 1992 and is identical to the strain isolated is the 2000s, except that the original CD NAP1 strain was not resistant to the new fluoroquinolone drugs of the time, which included gatifloxacin and moxifloxacin. Risk factors for infection with CD NAP1 include advanced age, hospitalization, and exposure to antibiotics, notably fluoroquinolones and cephalosporins. The elderly are especially vulnerable to infection, and have a 30-day mortality rate of more than 5%. PMID: 19457419 Source: Regenstrief LOINC

Fully-Specified Name

Component
Clostridioides difficile BI-NAP1-027 strain DNA
Property
PrThr
Time
Pt
System
Stool
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
C diff BI NAP1 027 DNA Stl Ql NAA+probe
Display Name
C. difficile BI-NAP1-027 strain DNA NAA+probe Ql (Stl)
Consumer Name Alpha Get Info
Clostridioides difficile BI-NAP1-027 strain, Stool

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.73
Change Reason
Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation
Both
Common Test Rank Get Info
13281

Example Answer List LL744-4

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Member of these Panels

LOINC Long Common Name
95183-0 Clostridioides difficile toxin and BI-NAP1-027 strain DNA panel - Stool by NAA with probe detection

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Clostridium diff. DNA (RT-027-Stamm) /ST ql. PCR
es-MX Spanish (Mexico) ADN de la cepa de Clostridioides difficile BI-NAP1-027:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ES Spanish (Spain) Cepa BI-NAP1-027 Clostridium difficile ADN:PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida
fr-FR French (France) Clostridioides difficile souche BI-NAP1-027 ADN:Présence/Seuil:Ponctuel:Selle:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Clostridium difficile BI-NAP1-027, variante DNA:PrThr:Pt:Feci:Ord:Sonda.amp.tar
Synonyms: Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Variante clostridium difficile BI-NAP1-027
zh-CN Chinese (China) 艰难梭菌 BI-NAP1-027 株 DNA:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 去氧核糖核酸;脱氧核糖核酸 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 艰难梭状芽胞杆菌;艰难芽孢梭菌 艰难梭菌（艰难梭状芽胞杆菌、艰难芽孢梭菌） BI-NAP1-027 株（菌株、分离株）

54067-4 Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

Fully-Specified Name

Component
Clostridioides difficile toxin genes
Property
PrThr
Time
Pt
System
Stool
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
C diff Tox gens Stl Ql NAA+probe
Display Name
C. difficile toxin genes NAA+probe Ql (Stl)
Consumer Name Alpha Get Info
Clostridioides difficile toxin genes, Stool

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.26
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016; Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation
Both
Common Test Rank Get Info
1296

Example Answer List LL360-9

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Panels

LOINC Long Common Name
95183-0 Clostridioides difficile toxin and BI-NAP1-027 strain DNA panel - Stool by NAA with probe detection

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Clostridium difficile Toxin-Gene /ST ql. PCR
es-MX Spanish (Mexico) Genes de la toxina de Clostridioides difficile:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ES Spanish (Spain) Genes toxinas Clostridium difficile:PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida
fr-BE French (Belgium) Gènes de la toxine du Clostridium difficile:PrThr:Temps ponctuel:Selles:Ordinal:Sonde avec amplification de la cible
Synonyms: Clostridium difficile. Gène Toxine.
fr-CA French (Canada) Gènes de la toxine du clostridioides difficile:Présence-Seuil:Temps ponctuel:Selles:Ordinal:Sonde avec amplification de la cible
fr-FR French (France) Clostridioides difficile toxine gènes:Présence/Seuil:Ponctuel:Selle:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Clostridium difficile, geni tossina:PrThr:Pt:Feci:Ord:Sonda.amp.tar
Synonyms: Geni di tossina di Clostridium difficile Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Tossina di Clostridium difficile
nl-NL Dutch (Netherlands) Clostridioides difficile toxinegenen:aanwezigheid:moment:feces:ordinaal:probe-detectie
Synonyms: Clostridium difficile Clostridium difficile toxine Clostridium difficile toxine genen ontlasting; feces probe.amp.tar
pt-BR Portuguese (Brazil) Clostridium difficile toxina gene:ACnc:Pt:Fezes:Ord:Sonda com limite de detecção da amplificação de alvo
Synonyms: ; C dif Tox gens; C diff; C difficile; Arbitrary concentration; Point in time; Random; Stl; Feces; Faeces; Bowel movement; Fecal; Faecal; Ql; Ordinal; QL; Qualitative; Qual; Screen; PCR; Polymerase chain reaction; Transcription mediated amplification; NASBA; Nucleic acid sequence based analysis; SDA; Strand Displacement Amplification; LAT; Ligation-activated transcription; 3SR SR; 3 Self-Sustaining Sequence Replication; LCR; Ligase chain reaction; QBR; Q-Beta Replicase or probe amplification category method; Probe with target amplification; NAAT; TMA; Amp Prb; Probe with ampification; DNA probe; Amplified; Microbiology
ru-RU Russian (Russian Federation) Clostridium difficile токсин гены:PrThr:ТчкВрм:Фекалии:Пор:Проба.усил.миш
Synonyms: ДНК проба;ДНК зонд Порядковый Проба с мишени усилением Точка во времени;Момент
tr-TR Turkish (Turkey) Clostridium difficile toksin genleri:MevcEşik:Zmlı:Dışkı:Srl:Prob.amf.hdf
Synonyms: Gaita; feçes Mevcut
zh-CN Chinese (China) 艰难梭菌毒素基因:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 分子病理学 - 基因类 基因 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 艰难梭状芽胞杆菌;艰难芽孢梭菌 艰难梭状芽胞杆菌毒素;艰难芽孢梭菌毒素 艰难梭状芽胞杆菌毒素基因;艰难芽孢梭菌毒素基因

74822-8 Clostridioides difficile toxin B tcdB gene [Presence] in Stool by NAA with probe detection

Term Description

Real-time polymerase chain reaction (PCR) assay for the rapid detection of the toxin B gene (tcdB) of Clostridium difficile. Fecal C. difficile toxin testing can aid the diagnosis of C. difficile-associated diarrhea in hospitalized patients.
Source: Regenstrief LOINC

Fully-Specified Name

Component
Clostridioides difficile toxin B tcdB gene
Property
PrThr
Time
Pt
System
Stool
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
C diff Tox B tcdB Stl Ql NAA+probe
Display Name
C. difficile toxin B tcdB gene NAA+probe Ql (Stl)
Consumer Name Alpha Get Info
Clostridioides difficile toxin B tcdB gene, Stool

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Added "tcdB gene" to the Component since this assay detects nucleic acids within the tcdB gene of C. difficile; Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation
Both
Common Test Rank Get Info
4577

Example Answer List LL2872-1

Answer Code Score Answer ID
Not detected LA11883-8
Present Copyright http://snomed.info/sct ID:52101004 Present (qualifier value) LA9633-4

Member of these Panels

LOINC Long Common Name
95183-0 Clostridioides difficile toxin and BI-NAP1-027 strain DNA panel - Stool by NAA with probe detection
106062-3 Enteric pathogen panel - Stool by NAA with probe detection

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Clostridium difficile Toxin-B-Gen /ST ql. PCR
es-MX Spanish (Mexico) Gen tcdB de la toxina B de Clostridioides difficile:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ES Spanish (Spain) Gen de la toxina B Clostridium difficile (tcdB):PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida
fr-CA French (Canada) Gène B toxine clostridioides difficile tcdB:Présence-Seuil:Temps ponctuel:Selles:Ordinal:Sonde avec amplification de la cible
fr-FR French (France) Clostridioides difficile toxine B tcdB gène:Présence/Seuil:Ponctuel:Selle:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Clostridium difficile tossina B, gene tcdB:PrThr:Pt:Feci:Ord:Sonda.amp.tar
Synonyms: Gene tcdB della tossina B di Clostridium difficile Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Tossina B di Clostridium difficile Tossina di Clostridium difficile
nl-NL Dutch (Netherlands) Clostridioides difficile toxine B tcdB-gen:aanwezigheid:moment:feces:ordinaal:probe-detectie
Synonyms: Clostridium difficile Clostridium difficile toxine Clostridium difficile toxine B ontlasting; feces probe.amp.tar
pt-BR Portuguese (Brazil) Clostridium difficile toxina B::Pt:Fezes:Ord:Sonda com limite de detecção da amplificação de alvo
zh-CN Chinese (China) 艰难梭菌毒素 B tcdB 基因:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
Synonyms: B 型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 艰难梭状芽胞杆菌;艰难芽孢梭菌 艰难梭状芽胞杆菌毒素 B;艰难梭状芽胞杆菌毒素 B 型;艰难梭菌毒素 B 型;艰难芽孢梭菌毒素 B;艰难芽孢梭菌毒素 B 型 艰难梭状芽胞杆菌毒素;艰难芽孢梭菌毒素 艰难梭菌（艰难梭状芽胞杆菌、艰难芽孢梭菌）毒素 B tcdB 基因 遗传基因;遗传因子;吉恩;生物基因

80685-1 Clostridioides difficile toxin A+B tcdA+tcdB genes [Presence] in Stool by NAA with probe detection

Term Description

Qualitative detection of nucleic acid sequences in the Clostridium difficile toxin A (tcdA) and B (tcdB) genes in stool specimens by real-time PCR methods. This assay does not differentiate between C. difficile toxin A and B genes. This term was created for, but not limited in use to, the submitter's test kit, xTAG® Gastrointestinal Pathogen Panel (GPP).
Source: Regenstrief LOINC

Part Descriptions

LP204848-8   Clostridioides difficile toxin A+B tcdA+tcdB genes
Clostridium difficile toxin's A and B are encoded by the tcdA and tcdB genes, respectively. PMID: 20664812 They share similar molecular characteristics with comparable sizes (308 kD for tcdA and 269 for tcdB) and 63% homology in their amino acid sequences. PMID: 9312171 TcdA and tcdB are expressed in response to environmental stresses, such as antibiotics.[ PMID 15831824] Nucleic acid sequences within these genes are targeted to confirm the presence of C. difficile toxins and diagnose the cause of diarrhea, abdominal pain, fever, nausea and other toxin-producing symptoms. Source: Regenstrief LOINC

Fully-Specified Name

Component
Clostridioides difficile toxin A+B tcdA+tcdB genes
Property
PrThr
Time
Pt
System
Stool
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
C dif tox tcdA+tcdB Stl Ql NAA+probe
Display Name
C. difficile toxin A+B tcdA+tcdB genes NAA+probe Ql (Stl)
Consumer Name Alpha Get Info
Clostridioides difficile toxin A+B tcdA+tcdB genes, Stool

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.73
Change Reason
Removed parentheses around the gene names in the Component based on the current LOINC model; Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation
Both
Common Test Rank Get Info
10075

Example Answer List LL360-9

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Panels

LOINC Long Common Name
95183-0 Clostridioides difficile toxin and BI-NAP1-027 strain DNA panel - Stool by NAA with probe detection
79381-0 Gastrointestinal pathogens panel - Stool by NAA with probe detection

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Clostridium difficile bin. Toxin-Gene /ST ql. PCR
de-DE German (Germany) Clostridioides difficile Toxine A+B tcdA+tcdB-Gene:Nachweis oder Schwellenwert:Zeitpunkt:Stuhl:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-MX Spanish (Mexico) Toxina de Clostridioides difficile A + B genes tcdA + tcdB:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
es-ES Spanish (Spain) Gen de la toxina del Clostridium difficile A+B (tcdA+tcdB):PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida
fr-FR French (France) Clostridioides difficile toxines A+B tcdA+tcdB gènes:Présence/Seuil:Ponctuel:Selle:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Clostridium Difficile (tcdA+tcdB), geni tossine A+B:PrThr:Pt:Feci:Ord:Sonda.amp.tar
Synonyms: Geni delle tossine A+B del Clostridium Difficile ( Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Tossina A di Clostridium difficile Tossina A+B di Clostridium difficile Tossina di Clostridium difficile
nl-NL Dutch (Netherlands) Clostridioides difficile toxine A+B (tcdA+tcdB) genen:aanwezigheid:moment:feces:ordinaal:probe-detectie
Synonyms: Clostridium difficile Clostridium difficile toxine Clostridium difficile toxine A Clostridium difficile toxine A+B Clostridium difficile toxine A+B (tcdA+tcdB) genen ontlasting; feces probe.amp.tar
zh-CN Chinese (China) 艰难梭菌毒素 A+B tcdA+tcdB 基因:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
Synonyms: A 型 A,B 型;AB 型 B 型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 分子病理学 - 基因类 基因 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 艰难梭状芽胞杆菌;艰难芽孢梭菌 艰难梭状芽胞杆菌毒素 A;艰难梭状芽胞杆菌毒素 A 型;艰难梭菌毒素 A 型;艰难芽孢梭菌毒素 A;艰难芽孢梭菌毒素 A 型 艰难梭状芽胞杆菌毒素 A+B;艰难梭状芽胞杆菌毒素 A+B 型;艰难梭菌毒素 A+B 型;艰难芽孢梭菌毒素 A+B;艰难芽孢梭菌毒素 A+B 型 艰难梭状芽胞杆菌毒素;艰难芽孢梭菌毒素 艰难梭菌毒素（艰难梭状芽胞杆菌、艰难芽孢梭菌） A+B tcdA+tcdB 基因