Version 2.78

Part Descriptions

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP21132-3   Chikungunya virus
A species of ALPHAVIRUS causing an acute dengue-like fever. Source: National Library of Medicine, MeSH 2006

LP21132-3   Chikungunya virus
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. PMID: 20111039
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage. Source: Regenstrief LOINC

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

Fully-Specified Name

Component
Chikungunya virus Ab.Neut
Property
Titr
Time
Pt
System
XXX
Scale
SemiQn
Method
Neut

Additional Names

Long Common Name
Chikungunya virus neutralizing antibody [Titer] in Specimen by Neutralization test
Short Name
CHIKV NAb Titr Spec Nt
Display Name
CHIKV neut ab Neut test (Specimen) [Titer]
Consumer Name Alpha Get Info
Chikungunya virus neutralizing antibody, Specimen

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.75
Change Reason
Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG51028-5 Chikungunya virus

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Virus Chikungunya Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:XXX:Semicuantitativo:Prueba de neutralización
Synonyms: Semicuantitativo
es-MX Spanish (Mexico) Virus de Chikungunya Ab:Título:Punto temporal:XXX:Cuantitativo:Prueba de neutralización
fr-FR French (France) Chikungunya virus Ac neutralisant:Titre:Ponctuel:Milieux divers:Semi-Quantitatif:Neutralisation
fr-CA French (Canada) Virus Chikungunya Ac.neut:Titre:Temps ponctuel:XXX:SemiQn:Test de neutralisation
it-IT Italian (Italy) Chikungunya virus Ab.Neut:Titr:Pt:XXX:SemiQn:Neut
Synonyms: anticorpo CHIK Microbiologia Punto nel tempo (episodio) Test di neutralizzazione Titolo
nl-NL Dutch (Netherlands) Chikungunya-virus As.neutraliserend:titer:moment:XXX:semikwantitatief:neutralisatietest
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Wirus Chikungunya Ab.Neutralizujące:miano:punkt w czasie:XXX:półilościowy:test neutralizacji
Synonyms: Przeciwciała do wirusa Chikungunya Przeciwciała neutralizujące do wirusa Chikungunya Wirus Chikungunya
zh-CN Chinese (China) 基孔肯亚病毒 抗体.中和:滴定度:时间点:XXX:半定量型:中和试验
Synonyms: Ab;自身抗体 CHIKV Ab CHIKV 抗体 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 中和试验;中和抗体;中和 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 基孔肯亚病毒 Ab 基孔肯雅病毒 Ab 基孔肯雅病毒抗体 奇昆古尼亚病毒;基孔肯雅病毒;CHIKV 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数 时刻;随机;随意;瞬间

Example Units

Unit Source
{titer} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95649-0