95823-1

SARS-related coronavirus E gene [Presence] in Saliva (oral fluid) by NAA with probe detection

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Term Description

Qualitative detection of nucleic acids within the envelope (E) gene of SARS coronavirus 2 (SARS-CoV-2) in saliva specimens by nucleic acid amplification with probe-based detection. Testing is performed for the diagnosis of COVID-19.
Source: Regenstrief LOINC

Part Descriptions

LP417600-6 SARS-related coronavirus E gene
The Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), first known as 2019 Novel Coronavirus (2019-nCoV), was first identified as the cause of a respiratory illness outbreak, later defined as Coronavirus Disease 2019 (COVID-19), in Wuhan, China. The full genome of the SARS-CoV-2 that causes COVID-19 was first posted by Chinese health authorities in GenBank, the NIH genetic sequence database, and in the Global Initiative on Sharing All Influenza Data (GISAI) portal. This facilitated detection of the virus globally with subsequent sequences being nearly identical, suggesting a single, recent emergence from a virus related to bat coronaviruses and the SARS coronavirus. Real time Reverse Transcription-Polymerase Chain Reaction (rRT-PCR) tests targeting regions within genes, including RdRp, S, N, M, and E genes, specific to SARS-CoV-2 have been developed by the Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO) and others for the diagnosis of COVID-19. Some assays only detect SARS-CoV-2 and other assays detect other strains (e.g. SARS-CoV) that are genetically similar.[CDC: coronavirus/2019-ncov][https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/laboratory-guidance] Source: Regenstrief LOINC

LP7565-7 Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583 Source: Regenstrief LOINC

Reference Information

Type	Source	Reference
Webcontent	Lab Tests Online^®Copyright Copyright © 2021 Lab Tests Online. All rights reserved.	Coronavirus (COVID-19) Testing
Mapping Guidance	LOINC	Take caution when mapping LOINC codes to molecular tests for SARS coronaviruses that target nucleic acids within the E gene. Such assays detect either SARS-related coronavirus or SARS-CoV-2, depending on the targeted region within the E gene. Assays that are non-specific to only SARS-CoV-2 may say they are "positive" for SARS-CoV-2, but only because it is the primary circulating virus during the pandemic. These assays actually detect any SARS-related coronaviruses since they target a region in the E gene that contains sequence homology to other known coronaviruses. Other assays target a region in the E gene that is specific for SARS-CoV-2. The LIVD file contains current LOINC code mappings to many IVD tests [https://www.cdc.gov/csels/dls/sars-cov-2-livd-codes.html]. You may also contact the manufacturer directly to verify LOINC code mappings.

Fully-Specified Name

Component: SARS-related coronavirus E gene
Property: PrThr
Time: Pt
System: Saliva
Scale: Ord
Method: Probe.amp.tar

Additional Names

Short Name: SARS-rel CoV E gene Sal Ql NAA+probe
Display Name: SARS-related coronavirus E gene NAA+probe Ql (Sal)
Consumer Name Alpha Get Info: SARS-related coronavirus E gene, Saliva

Example Answer List: LL5508-8

Source: Centers for Disease Control and Prevention

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value)			LA9663-1
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value)			LA15841-2

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.69
Last Updated: Version 2.69
Order vs. Observation: Observation

Member of these Panels

LOINC	Long Common Name
98080-5	SARS-CoV-2 (COVID-19) and SARS-related CoV RNA panel - Saliva (oral fluid) by NAA with probe detection
95826-4	SARS-CoV-2 (COVID-19) RNA panel - Saliva (oral fluid) by NAA with probe detection

Member of these Groups Get Info

LOINC Group	Group Name
LG50982-4	SARS-related coronavirus

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	SARS-bezogenes Coronavirus E-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Speichel:Ordinal:Zielfragmentamplifikation mit Sondendetektion
es-ES	Spanish (Spain)	Gen del coronavirus E relacionado con el SARS:PrThr:Punto temporal:Saliva:Ord:Sonda con amplificación dirigida
es-MX	Spanish (Mexico)	Gen del coronavirus E relacionado con el SARS:Presencia o umbral:Punto temporal:Saliva:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-CA	French (Canada)	Gène E du coronavirus lié du SRAS:Présence-Seuil:Temps ponctuel:Salivaire:Ordinal:Sonde avec amplification de la cible
fr-FR	French (France)	Coronavirus SARS apparentés gène E:Présence/Seuil:Ponctuel:Salive:Qualitatif:PCR amplification de cible
it-IT	Italian (Italy)	Coronavirus correlato a SARS, gene E:PrThr:Pt:Saliva:Ord:Sonda.amp.tar Synonyms: Gene E di coronavirus correlato a SARS Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL	Dutch (Netherlands)	SARS-gerelateerd coronavirus E-gen:aanwezigheid:moment:speeksel:ordinaal:probe-detectie Synonyms: probe.amp.tar
zh-CN	Chinese (China)	SARS 冠状病毒 2 E 基因:存在情况或阈值:时间点:唾液:序数型:探针法.基因扩增.靶向 Synonyms: 2019 新型冠状病毒;2019 年新型冠状病毒;2019-nCoV;SARS-CoV-2;新型冠状病毒肺炎;新冠肺炎;Coronavirus disease 2019;COVID-19;冠状病毒疾病2019;严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典 E 型严重急性呼吸综合征;severe acute respiratory syndrome;SARS;传染性非典型肺炎;infectious atypical pneumonia;非典依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间津;津液;涎经过扩增的脱氧核糖核酸探针遗传基因;遗传因子;吉恩;生物基因

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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.