Version 2.78

Term Description

Qualitative detection of nucleic acids within the mobilized colistin resistance (mcr) genes 3-5 (mcr-3, mcr-4, mcr-5) found in Gram-negative bacteria. Testing may be performed in addition to conventional culture susceptibility testing to determine the potential bacterial resistance mechanism to antibiotics.
Source: Regenstrief LOINC

Part Description

LP426517-1   Bacterial colistin resistance mcr-3+mcr-4+mcr-5 genes
The mobilized colistin resistance genes (mcr-1 to mcr-5, and variants) are located on a plasmid within bacterial cells and affect the ability of antibiotics, including polymyxins and colistin, to bind to the bacteria. The mode of action of the antibiotics is to bind to the outer membrane of the phosphate group of lipid A lipopolysaccharide and to intercalate into the inner membrane forming pores that result in bacterial lysis. The polymyxins & colistin are the last line of defense used to treat multidrug resistant gram-negative bacteria so the emergence of the mcr genes in Enterobacteriaceae, including Klebsiella pneumoniae, is onerous and challenging to public health. PMID: 27893854 PMID: 29439754 Source: Regenstrief LOINC

Fully-Specified Name

Component
Bacterial colistin resistance mcr-3+mcr-4+mcr-5 genes
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Long Common Name
Colistin resistance mcr-3+mcr-4+mcr-5 genes [Presence] by Molecular method
Short Name
Colistin res mcr-(3-5) Islt/Spm Ql
Display Name
Colistin resistance mcr-3+mcr-4+mcr-5 genes Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Colistin resistance mcr-3+mcr-4+mcr-5 genes

Example Answer List: LL2021-5

Source: Gen-Probe
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.70
Last Updated
Version 2.72
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Bakterielle Colistin-Resistenz mcr-3+mcr-4+mcr-5-Gene:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) genes bacterianos mcr-3 + mcr-4 + mcr-5 resistentes a colistina:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Resistencia a la colistina bacteriana genes mcr-3 + mcr-4 + mcr-5:PrThr:Punto temporal:Aislar / Muestra:Ordinal:Molgen
fr-FR French (France) Résistance bactérienne à la colistine mcr-3+mcr-4+mcr-5 gènes:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Geni mcr-3+mcr-4+mcr-5 di resistenza batterica alla colistina:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Genetica molecolare Isolato o Campione Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) bacteriële colistineresistentie mcr-3+mcr-4+mcr-5-genen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 细菌粘菌素耐药 mcr-3+mcr-4+mcr-5 基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: Ⅲ III 三 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子病理学 - 基因类 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 叁 受检物 基因 多粘菌素 E;抗敌素;粘杆菌素;肠杆菌素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 细菌性 细菌的 细菌粘菌素（多粘菌素 E、抗敌素、粘杆菌素、肠杆菌素）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型） mcr-3+mcr-4+mcr-5 基因 耐性 试样 阻力

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=98066-4