Version 2.78

Part Description

LP429547-5   Bacterial trimethoprim resistance dfrA12 gene
Dihydrofolate reductase (DHFR) is an enzyme that changes dihydrofolate to tetrahydrofolate, required for the synthesis of purines, thymidylic acid, and certain amino acids. Due to its critical function, DHFR is found in all organisms. In humans it is encoded by the DHFR gene, and can be the target of drugs such as methotrexate used to treat certain neoplasms and inflammatory diseases. In bacteria, the bacterial DHFR enzyme is targeted by synthetic antibiotics such as trimethoprim. The chromosomal version of the bacterial gene (commonly folA) is sometimes overridden by trimethoprim-resistant versions present on mobile elements. Mutations of DHFR resulted in widespread resistance to trimethoprim. The dfrA class of genes are found to be the largest family of mobile trimethoprim antibiotic resistance genes. PMID: 20169085, [Wiki: Dihydrofolate_reductase] Source: Regenstrief LOINC

Fully-Specified Name

Component
Bacterial trimethoprim resistance dfrA12 gene
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
dfrA12 Islt/Spm Ql
Display Name
Trimethoprim resistance dfrA12 gene Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Trimethoprim resistance dfrA12 gene

Example Answer List: LL2021-5

Source: Gen-Probe
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.72
Last Updated
Version 2.72
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
99012-7 Urinary tract pathogens panel - Urine by NAA with probe detection

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Bakterielle Trimethoprim-Resistenz dfrA12-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Gen dfrA12 de resistencia bacteriana a la trimetoprima:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
fr-FR French (France) Résistance bactérienne au triméthoprime dfrA12 gène:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Resistenza batterica al trimetoprim, gene dfrA12:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Gene dfrA12 resistenza al trimetoprim Genetica molecolare Isolato o Campione Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) bacteriële trimethoprimresistentie dfrA12-gen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 细菌三甲氧苄二氨嘧啶耐药 dfrA12 基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: 三甲氧下二氨嘧啶;三甲氧苄二氨嘧啶(一种抗菌素,用以治疗疟疾及呼吸道或尿路感染);甲氧下氨嘧啶;甲氧苄氨嘧啶;磺胺增效剂 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 受检物 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 细菌三甲氧苄二氨嘧啶（TMP、三甲氧下二氨嘧啶、甲氧下氨嘧啶、甲氧苄氨嘧啶、磺胺增效剂）耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型） dfrA12 基因 细菌性 细菌的 耐性 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=99037-4