Version 2.78

Part Description

LP30803-8   PL-12
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component
PL-12 Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
Line blot

Additional Names

Short Name
PL12 Ab Ser Line blot-aCnc
Display Name
PL-12 Ab Line blot Qn (S)
Consumer Name Alpha Get Info
PL-12 antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.72
Last Updated
Version 2.72
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
88883-4 Connective tissue autoimmune Ab panel - Serum

Member of these Groups Get Info

LOINC Group Group Name
LG51679-5 PL-12 Ab|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Pl-12 Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot
Synonyms: Cuantitativo
fr-CA French (Canada) Pl-12, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR French (France) PL-12 anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT Italian (Italy) PL-12 Ab:ACnc:Pt:Siero:Qn:Line blot
Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) PL-12 As:eenheid/volume:moment:serum:kwantitatief:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) Pl-12 抗体:任意型浓度:时间点:血清:定量型:线点印迹法
Synonyms: Ab;自身抗体 Pl-12 Ab 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 先天性炎性肌病 先天性炎症性肌病 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 特发性炎性肌病 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=99066-3