LP15216-2
LW
Active
Descriptions
The LW and D antigens are closely related. Rh+ red cells express LW more strongly than Rh negative cells. The early nomenclature tried to accommodate this observation by using a numerical system; eg. LW1, LW2, etc. but this changed following Sistonen's report of a new low frequency antigen called Ne^a which was found in ~5% of Finns. Because further work suggested that the Ne^a gene was allelic to LW, they were renamed LW^a and LW^b (Ne^a). Thus, the null phenotype for this system would be LW(a-b-) which is extremely rare and is the result of a partial gene deletion. A transient or acquired form of LW(a-b-) has been reported and these individuals are found because they produce a transient anti-LW. Some (but not all) examples have been associated with terminal illnesses such as Hodgkin's disease, leukemia, sarcomas or other malignancies. Source: Serum, Cells and Rare Fluid Exchange , LW
Although genetically independent of the Rh system, the Landsteiner Wiener (LW) blood group antigen system is part of the Rh protein cluster and is expressed more strongly on D positive cells. There are 2 antithetical alleles, LW^a and LW^b with 4 possible phenotypes: LW(a+b-), LW(a-b+), LW(a+b+), and LW(a-b-).(Schenkel-Brunner H. (2000) Landsteiner-Wiener System. In: Human Blood Groups. Springer, Vienna) LW^a has much higher prevalence than LW^b in most populations. Hemolytic disease of the newborn due to anti-LW is rare and mild when it does occur [https://en.wikipedia.org/wiki/ICAM4]. Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- LW
- Part Display Name
- LW
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- LW
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | LW Synonyms: Landsteiner-Wiener (LW); |
| es-ES | Spanish (Spain) | Grupo sanguíneo LW |
| it-IT | Italian (Italy) | LW |
| et-EE | Estonian (Estonia) | LW |
| tr-TR | Turkish (Turkey) | LW |
| ru-RU | Russian (Russian Federation) | LW |
| fr-BE | French (Belgium) | LW |
| fr-CA | French (Canada) | LW |
| nl-NL | Dutch (Netherlands) | LW |
| el-GR | Greek (Greece) | LW Synonyms: LW |
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