LP15254-3
Ascorbate
Active
Descriptions
Promotes the conversion of tropocollagen to collagen and is involved in the production of adrenal cortical steroids and the metabolism of tyrosine and folate. In addition, it appears to function in a variety of other metabolic processes in which its role has not been characterized.The need for Vitamin C can be increased by the use of asprin, oral contraceptives, tetracyclines and other medications. Chronic injestion of large doses has been a common-place practice for several years with no apparently harmful effect. Source: Regenstrief Institute
Ascorbic acid is an essential nutrient in human diets, and is necessary to maintain connective tissue and bone. The biologically active form of ascorbic acid is vitamin C. Vitamin C is a water soluble vitamin. Primates (including humans) and a few other species in all divisions of the animal kingdom, notably the guinea pig, have lost the ability to synthesize ascorbic acid and must obtain it in their food. Ascorbic acid is an electron donor for enzymes involved in collagen hydroxylation, biosynthesis of carnitine and norepinephrine, tyrosine metabolism, and amidation of peptide hormones. Ascrobic acid (vitamin C) deficiency causes scurvy. The amount of vitamin C necessary to prevent scurvy may not be adequate to maintain optimal health. The ability of vitamin C to donate electrons also makes it a potent water-soluble antioxidant that readily scavenges free radicals such as molecular oxygen, superoxide, hydroxyl radical, and hypochlorous acid. In this setting, several mechanisms could account for a link between vitamin C and heart disease. One is the relation between LDL oxidation and vitamins C and E. Vitamin C in vitro can recycle vitamin E, which can donate electrons to prevent LDL oxidation in vitro. As the lipid-phase vitamin E is oxidized, it can be regenerated by aqueous vitamin C. Other possibilities are that vitamin C could decrease cholesterol by mechanisms not well characterized, or could improve vasodilatation and vascular reactivity, perhaps by decreasing the interactions of nitric oxide with oxidants. PMID: 10799361. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Ascorbate
Basic Part Properties
- Part Display Name
- Ascorbate
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Vit C
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 抗坏血酸 Synonyms: Vit C; |
| fr-CA | French (Canada) | Ascorbate |
| et-EE | Estonian (Estonia) | Askorbaat |
| es-ES | Spanish (Spain) | Ascorbato |
| it-IT | Italian (Italy) | Ascorbato |
| tr-TR | Turkish (Turkey) | Askorbat |
| ru-RU | Russian (Russian Federation) | Аскорбат |
| nl-NL | Dutch (Netherlands) | ascorbaat Synonyms: vitamine C |
| fr-BE | French (Belgium) | Ascorbate |
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