LP157499-7
UGT1A1 gene.c.A(TA)7TAA(*28)
Active
Description
The presence of an additional TA repeat in the TATA region of the UGT1A1 promoter (ie, 7 TA repeats; UGT1A1*28, rs8175347) markedly reduces the level of hepatic bilirubin UDP-glucuronosyltransferase 1A1 (UGT1A1), the enzyme necessary for the conjugation of bilirubin. Individuals homozygous for the UGT1A1*28 allele develop Gilbert syndrome, a condition characterized by periods of mild unconjugated hyperbilirubinemia. In addition, individuals positive for the UGT1A1*28 allele are more likely to experience severe adverse effects during irinotecan chemotherapy. Identifying a patient's genotype for the UGT1A1 allele helps determine appropriate starting dosages for irinotecan, reducing the risk of severe toxicity and improving overall therapy. Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- UGT1A1 gene c.A(TA)7TAA(*28)
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2012-10-01
- Construct for LOINC Short Name
- UGT1A1*28
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | UGT1A1 基因.c.A(TA)7TAA(*28) |
| es-ES | Spanish (Spain) | gen UGT1A1.c.A(TA)7TAA(*28) |
| it-IT | Italian (Italy) | UGT1A1, gene.c.A(TA)7TAA(*28) Synonyms: Gene UGT1A1 c.A(TA)7TAA(*28) |
| tr-TR | Turkish (Turkey) | UGT1A1 geni.c.A(TA)7TAA(*28) |
| ru-RU | Russian (Russian Federation) | UGT1A1 ген.c.A(TA)7TAA(*28) |
| nl-NL | Dutch (Netherlands) | UGT1A1-gen.c.A(TA)7TAA(*28) |
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