LP16352-4
Complement C1q
Active
Descriptions
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. Source: National Library of Medicine, MeSH 2006
The complement system is a key part of the immune system and inflammatory response. The system has three pathways: 1) the classic pathway, 2) the alternative pathway, and 3) the lectin activation pathway. Complement (C1) is composed of 3 subunits: C1q, C1r, and C1s. Complement C1q initiates the complement pathway by binding to immunoglobulins. Absent or decreased levels of Complement C1q are seen in patients with acquired angioedema, systemic lupus erythematosus (SLE), polymyositis, and other immune complex diseases. Complement tests measure either the quantity or the activity (function) of complement proteins. In some cases, complement proteins are present but not functional, in which case a functional assay is used to detect the deficiency. Source: Regenstrief Institute
Basic Part Properties
- Part Name
- Complement C1q
- Part Display Name
- Complement C1q
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- C1q
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 补体 C1q |
| fr-CA | French (Canada) | Complément C1q |
| et-EE | Estonian (Estonia) | Komplemendi komponent C1q |
| es-ES | Spanish (Spain) | Complemento C1q |
| it-IT | Italian (Italy) | Complemento C1q |
| tr-TR | Turkish (Turkey) | Kompleman C1q |
| ru-RU | Russian (Russian Federation) | Комплемент C1q |
| nl-NL | Dutch (Netherlands) | complement C1q |
| fr-BE | French (Belgium) | Complément C1q |
LOINC Copyright
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