Version 2.77

Description

Topoisomerase I (also known as Scl-70) is a nuclear enzyme that plays a role in releasing tension that is introduced in double-stranded DNA during DNA replication by transiently cleaving and rejoining one strand of the DNA duplex. Anti-Scl-70 autoantibodies are a marker of systemic sclerosis as well as other autoimmune diseases, including systemic lupus erythematosus (SLE). In patients with systemic sclerosis, anti-SCL-70 may be associated with more severe disease, and in patients with SLE, anti-SCL-70 suggests an increased risk of pulmonary hypertension and renal involvement. In general, anti-SCL-70 antibody status may help with diagnosis, treatment planning and prognosis in patients with connective tissue disease. PMID: 11229469 Source: Regenstrief LOINC, PMID: 11229469

Basic Part Properties

Part Display Name
SCL-70 extractable nuclear
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
ENA Scl70

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP16758-2

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) SCL-70 可提取性核
Synonyms: ENA SCL-70;SCL-70 可提取性核 Ag;SCL-70 可提取性核抗原;可提取性核抗原 SCL-70;皮硬化症 Ab;皮硬化症抗体;硬皮病 Ab;硬皮病抗体;硬皮症 Ab;硬皮症抗体
fr-CA French (Canada) SCL-70 nucléaire soluble
es-ES Spanish (Spain) Antígeno nuclear extraíble SCL-70
it-IT Italian (Italy) Nucleare estraibile SCL-70
tr-TR Turkish (Turkey) SCL-70 özütlenebilir nükleer
ru-RU Russian (Russian Federation) SCL-70 экстрагируемый ядерный
nl-NL Dutch (Netherlands) SCL-70 extraheerbare nucleaire
fr-BE French (Belgium) SCL-70 nucléaire soluble
pl-PL Polish (Poland) SCL-70 rozpuszczalny jądrowy
Synonyms: SCL-70 rozpuszczalny jądrowy