LP16906-7
von Willebrand factor
Active
Descriptions
Von Willebrand factor (vWF) is a high-molecular-weight plasma protein produced by endothelial cells and megakaryocytes. It is part of the factor VIII/vWF complex. The vWF has receptors for collagen, platelets, and ristocetin. Ristocetin is an antibiotic, previously used to treat staphylococcal infections, now mainly used in vitro to diagnose conditions such as von Willebrand disease. Platelet agglutination caused by ristocetin can occur only in the presence of von Willebrand factor multimers, so if ristocetin is added to blood lacking the factor it will not coagulate. The vWF facilitates the adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in von Willebrand's disease is due to the deficiency of this factor. Source: National Library of Medicine, MeSH 2006
Von Willebrand disease (vWD) is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion. Other factors including ABO blood groups may also play a part in the severity of the condition. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Display Name
- von Willebrand factor (vWf)
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- vWF
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | von Willebrand 因子 Synonyms: von Willebrand 因子（von Willebrand Factor， |
| fr-CA | French (Canada) | Facteur von Willebrand |
| et-EE | Estonian (Estonia) | Von Willebrand faktor |
| es-ES | Spanish (Spain) | Factor de Von Willebrand |
| it-IT | Italian (Italy) | von Willebrand, fattore Synonyms: Fattore di von Willebrand (vWf) |
| tr-TR | Turkish (Turkey) | von Willebrand faktörü |
| ru-RU | Russian (Russian Federation) | von Willebrand фактор (vWf) |
| nl-NL | Dutch (Netherlands) | von Willebrand-factor |
| fr-BE | French (Belgium) | Facteur von Willebrand Synonyms: Fvw |
| pl-PL | Polish (Poland) | Czynnik von Willebranda Synonyms: Czynnik von Willebranda (vWf) |
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