Version 2.78

Descriptions

Ceftolozane/tazobactam is a first-line IV therapy for the treatment of certain serious Gram-negative bacterial infections, including those caused by multi-drug resistant Pseudomonas aeruginosa. Source: Regenstrief LOINC

Ceftolozane is a cephalosporin with powerful activity against Gram-negative bacteria including Pseudomonas aeruginosa and Enterobacteriaceae.[http://aac.asm.org/content/57/4/1577.full] Tazobactam is a beta lactamase inhibitor and penicillin derivative that is effective against beta-lactamase-producing bacteria.[PubChem: 123630] Ceftolozane blocks penicillin binding proteins which disrupts bacterial cell-wall synthesis that leads to bacterial cell death. When tazobactam is added to ceftolozane, there is a broader spectrum of antimicrobial activity against resistant strains including extended spectrum beta-lactamases (ESBLs).Tazobactam prevents class A beta-lactamases and some class C beta-lactamases from hydrolyzing ceftolozane. Together, ceftolozane+tazobactam are an effective treatment for complicated urinary tract infections, complicated intra-abdominal infections, hospital-acquired bacterial pneumonia, and ventilator-associated bacterial pneumonia. PMID: 25516692 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Ceftolozane+Tazobactam
Part Type
Component (Describes the core component or analyte measured)
Created On
2013-01-30
Construct for LOINC Short Name
Ceftolozane+Tazobactam

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP172561-5

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 头孢洛林+他唑巴坦
Synonyms: 头孢洛林（头孢洛林酯、头孢他诺林、头孢他洛林酯、头孢他洛林）+他唑巴坦（他左巴坦、他巴克坦）
es-ES Spanish (Spain) Ceftolozane+Tazobactam
it-IT Italian (Italy) Ceftolozane+Tazobactam
tr-TR Turkish (Turkey) Seftolozan+Tazobaktam
ru-RU Russian (Russian Federation) Цефтолозан+Тазобактам
nl-NL Dutch (Netherlands) ceftolozaan + tazobactam