LP17839-9
Mononuclear cells
Active
Description
A Peripheral Blood Mononuclear Cell (PBMC) is a blood cell having a round nucleus, such as a lymphocyte or a monocyte. These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of T cells (CD4 and CD8 positive ~75%), B cells and NK cells (~25% combined).
These cells are often extracted from whole blood using ficoll, a hydrophilic polysaccharide that separates layers of blood, with monocytes and lymphocytes forming a buffy coat under a layer of plasma. This buffy coat contains the PBMCs. Additionally, PBMC can be extracted from whole blood using a hypotonic lysis which will preferentially lyse red blood cells. This method results in neutrophils and other polymorphonuclear (PMN) cells which are important in innate immune defense to be obtained.
PBMCs are widely used in research and clinical uses every day. HIV research uses them because PBMCs include CD4+ cells, the cells HIV infects.
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Source: Wikipedia, Mononuclear cell
Basic Part Properties
- Part Display Name
- Mononuclear cells
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Mononuc Cells
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 单个核细胞 Synonyms: 单个核 |
| fr-CA | French (Canada) | Cellules mononucléaires |
| et-EE | Estonian (Estonia) | Mononukleaarsed rakud |
| es-ES | Spanish (Spain) | Mononucleares |
| it-IT | Italian (Italy) | Cellule mononucleari |
| tr-TR | Turkish (Turkey) | Mononükleer hücreler |
| ru-RU | Russian (Russian Federation) | Мононуклеарные клетки |
| nl-NL | Dutch (Netherlands) | mononucleaire cellen |
| fr-BE | French (Belgium) | Cellules mononucléaires Synonyms: Cellules mononucléées |
| pl-PL | Polish (Poland) | Mononuklearne komórki Synonyms: Mononuklearne komórki |
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