Version 2.77

Description

The complement terminal complement complex (TCC) is comprised of complements C5b, C6, C7, C8, and C9 (C5b-9) and is a marker of complement activation. There are two forms of TCC: 1. Soluble TCC is formed when C5b-7 that is not associated with a lipid membrane binds to C8 and C9. SC5b-9 is soluble TCC that is bound to a plasma protein such as S-protein (vitronectin) or clusterin. Plasma SC5b-9 is the non-functional form of C5b-9 and is a non-specific marker of complement activation and inflammation.; 2. The membrane attack complex (MAC), a barrel-like structure spanning a cell's lipid bilayer that mediates complement cytotoxicity, is formed when C8 and C9 bind to C5b-7 that is already associated with a membrane, and is the functional form of C5b-9. PMID: 27782334 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Complement Sc5b-9
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
SC5b9

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP18271-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 补体 Sc5b-9
Synonyms: 终末补体复合体（Terminal complement complex）;终末补体复合物（Terminal complement complex）;补体可溶性 C5b-9
fr-CA French (Canada) Complément Sc5b-9
es-ES Spanish (Spain) Complemento Sc5b-9
it-IT Italian (Italy) Complemento Sc5b-9
tr-TR Turkish (Turkey) Kompleman Sc5b-9
ru-RU Russian (Russian Federation) Комплемент Sc5b-9
nl-NL Dutch (Netherlands) complement Sc5b-9
fr-BE French (Belgium) Complément Sc5b-9